(Q41204206)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28765606%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

title

2-Oxoesters: A Novel Class of Potent and Selective Inhibitors of Cytosolic Group IVA Phospholipase A2 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28765606%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

3

1 reference

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26 March 2020

Edward A. Dennis

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28765606%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

George Kokotos

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28765606%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

author name string

Maroula G Kokotou

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28765606%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Gerasimia Galiatsatou

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28765606%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Giorgos Koutoulogenis

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28765606%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Efrosini Barbayianni

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28765606%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Dimitris Limnios

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28765606%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Varnavas D Mouchlis

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28765606%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Banita Satpathy

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28765606%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

Aaron Navratil

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28765606%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

language of work or name

English

0 references

publication date

1 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28765606%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28765606%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28765606%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28765606%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

page(s)

7025

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28765606%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

26 March 2020

copyright license

start time

1 August 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/s41598-017-07330-5

0 references

cites work

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28 September 2017

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Development of a potent 2-oxoamide inhibitor of secreted phospholipase A2 guided by molecular docking calculations and molecular dynamics simulations

28 September 2017

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28 September 2017

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Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation.

28 September 2017

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28 September 2017

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Synthetic and natural inhibitors of phospholipases A2: their importance for understanding and treatment of neurological disorders

28 September 2017

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Cytosolic phospholipase A₂: physiological function and role in disease

28 September 2017

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Membranes serve as allosteric activators of phospholipase A2, enabling it to extract, bind, and hydrolyze phospholipid substrates

28 September 2017

1 reference

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Inhibition of group IVA cytosolic phospholipase A2 by thiazolyl ketones in vitro, ex vivo, and in vivo

28 September 2017

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Design, synthesis, and biological evaluation of 3-(1-Aryl-1H-indol-5-yl)propanoic acids as new indole-based cytosolic phospholipase A2α inhibitors.

28 September 2017

1 reference

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Comprehensive ultra-performance liquid chromatographic separation and mass spectrometric analysis of eicosanoid metabolites in human samples

28 September 2017

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New potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A2.

28 September 2017

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28 September 2017

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Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention

28 September 2017

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Specificity of eicosanoid production depends on the TLR-4-stimulated macrophage phenotype

28 September 2017

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Recent progress in phospholipase A₂ research: from cells to animals to humans

28 September 2017

1 reference

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Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.

28 September 2017

1 reference

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Location of inhibitors bound to group IVA phospholipase A2 determined by molecular dynamics and deuterium exchange mass spectrometry

28 September 2017

1 reference

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Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes

28 September 2017

1 reference

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Indole cytosolic phospholipase A2 alpha inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib

28 September 2017

1 reference

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Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha

28 September 2017

1 reference

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Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes

28 September 2017

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Properties of the Group IV phospholipase A2 family

28 September 2017

1 reference

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Differential inhibition of group IVA and group VIA phospholipases A2 by 2-oxoamides

28 September 2017

1 reference

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Inhibition of cytosolic phospholipase A2alpha: hit to lead optimization

28 September 2017

1 reference

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Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release

28 September 2017

1 reference

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Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition.

28 September 2017

1 reference

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Inhibition of group IVA cytosolic phospholipase A2 by novel 2-oxoamides in vitro, in cells, and in vivo

28 September 2017

1 reference

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Prostaglandins and leukotrienes: advances in eicosanoid biology

28 September 2017

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Pyrrolidine inhibitors of human cytosolic phospholipase A2. Part 2: synthesis of potent and crystallized 4-triphenylmethylthio derivative 'pyrrophenone'.

28 September 2017

1 reference

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The expanding superfamily of phospholipase A(2) enzymes: classification and characterization

28 September 2017

1 reference

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Cyclooxygenases: structural, cellular, and molecular biology

28 September 2017

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Alpha-ketoamides, alpha-ketoesters and alpha-diketones as HCV NS3 protease inhibitors

28 September 2017

1 reference

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Pyrrolidine inhibitors of human cytosolic phospholipase A(2).

28 September 2017

1 reference

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Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism

28 September 2017

1 reference

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Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine

28 September 2017

1 reference

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Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2

28 September 2017

1 reference

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Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2.

28 September 2017

1 reference

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A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5539244

2-Oxoamide inhibitors of cytosolic group IVA phospholipase A2 with reduced lipophilicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5539244

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5539244

New potential immunoenhancing compounds. Synthesis and pharmacological evaluation of new long-chain 2-amido-2-deoxy-D-glucose derivatives.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5539244

The Ca2(+)-sensitive cytosolic phospholipase A2 is a 100-kDa protein in human monoblast U937 cells

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5539244

Chiral surfactant-type catalyst: enantioselective reduction of long-chain aliphatic ketoesters in water

17 June 2018

1 reference

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1-(5-carboxyindol-1-yl)propan-2-one inhibitors of human cytosolic phospholipase A(2)alpha with reduced lipophilicity: synthesis, biological activity, metabolic stability, solubility, bioavailability, and topical in vivo activity

19 August 2018

1 reference

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Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2alpha: optimization of in vitro potency and rat pharmacokinetics for oral efficacy

19 August 2018

1 reference

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Structure-activity relationship of 2-oxoamide inhibition of group IVA cytosolic phospholipase A2 and group V secreted phospholipase A2.

19 August 2018

1 reference

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Novel 2-oxoamide inhibitors of human group IVA phospholipase A(2).

19 August 2018

1 reference

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

19 August 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41598-017-07330-5

A cytosolic phospholipase in human neutrophils that hydrolyzes arachidonoyl-containing phosphatidylcholine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41598-017-07330-5

7 January 2021

Solubilization and properties of Ca2+-dependent human platelet phospholipase A2

1 reference

https://api.crossref.org/works/10.1038%2FS41598-017-07330-5

7 January 2021

Design and synthesis of 1-indol-1-yl-propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha

1 reference

https://api.crossref.org/works/10.1038%2FS41598-017-07330-5

7 January 2021

1-(5-Carboxy- and 5-carbamoylindol-1-yl)propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha: bioisosteric replacement of the carboxylic acid and carboxamide moiety

1 reference

https://api.crossref.org/works/10.1038%2FS41598-017-07330-5

7 January 2021

1-(2-Carboxyindol-5-yloxy)propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha: synthesis, biological activity, metabolic stability, and solubility

1 reference

https://api.crossref.org/works/10.1038%2FS41598-017-07330-5

7 January 2021

1-(5-Carboxyindol-1-yl)propan-2-one inhibitors of human cytosolic phospholipase A2α: effect of substituents in position 3 of the indole scaffold on inhibitory potency, metabolic stability, solubility, and bioavailability

1 reference

https://api.crossref.org/works/10.1038%2FS41598-017-07330-5

7 January 2021

Alpha-diketone and alpha-keto ester derivatives of N-protected amino acids and peptides as novel inhibitors of cysteine and serine proteinases

1 reference

https://api.crossref.org/works/10.1038%2FS41598-017-07330-5

7 January 2021

Synthesis of peptidyl fluoromethyl ketones and peptidyl alpha-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, and rat and human neutrophil cathepsin G

1 reference

https://api.crossref.org/works/10.1038%2FS41598-017-07330-5

7 January 2021

Peptide alpha-keto ester, alpha-keto amide, and alpha-keto acid inhibitors of calpains and other cysteine proteases

1 reference

https://api.crossref.org/works/10.1038%2FS41598-017-07330-5

7 January 2021

The diminished production of arachidonic acid oxygenation products by elicited mouse peritoneal macrophages: possible mechanisms

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28765606

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/S41598-017-07330-5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28765606%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28765606%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

PubMed publication ID

28765606

1 reference