(Q30785490)

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Development of Potent and Selective Inhibitors for Group VIA Calcium-Independent Phospholipase A2 Guided by Molecular Dynamics and Structure-Activity Relationships

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scholarly article

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Europe PubMed Central

PMC publication ID

18 August 2017

Development of Potent and Selective Inhibitors for Group VIA Calcium-Independent Phospholipase A2 Guided by Molecular Dynamics and Structure-Activity Relationships (English)

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

molecular dynamics simulation

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Edward A. Dennis

object named as

Edward A Dennis

7

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J. Andrew McCammon

6

object named as

J Andrew McCammon

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

author name string

Varnavas D Mouchlis

1

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Dimitris Limnios

2

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Maroula G Kokotou

3

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Efrosini Barbayianni

4

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

George Kokotos

5

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Europe PubMed Central

PMC publication ID

18 August 2017

language of work or name

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publication date

17 April 2016

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Europe PubMed Central

PMC publication ID

18 August 2017

Journal of Medicinal Chemistry

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Europe PubMed Central

PMC publication ID

18 August 2017

59

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Europe PubMed Central

PMC publication ID

18 August 2017

9

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

4403-4414

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Membrane and inhibitor interactions of intracellular phospholipases A2.

1 reference

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1 reference

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Calcium-independent phospholipases A2 and their roles in biological processes and diseases.

1 reference

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Membranes serve as allosteric activators of phospholipase A2, enabling it to extract, bind, and hydrolyze phospholipid substrates

1 reference

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Insertion of the Ca²⁺-independent phospholipase A₂ into a phospholipid bilayer via coarse-grained and atomistic molecular dynamics simulations

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New potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A2.

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Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention

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Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.

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Diabetes-induced oxidative stress is mediated by Ca2+-independent phospholipase A2 in neutrophils

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Location of inhibitors bound to group IVA phospholipase A2 determined by molecular dynamics and deuterium exchange mass spectrometry

1 reference

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Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology

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Role of calcium-independent phospholipase A2 in the pathogenesis of Barth syndrome

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Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes

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Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes

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Differential inhibition of group IVA and group VIA phospholipases A2 by 2-oxoamides

1 reference

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Novel procedure for modeling ligand/receptor induced fit effects.

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Scalable molecular dynamics with NAMD

1 reference

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Localization and functional interrelationships among cytosolic Group IV, secreted Group V, and Ca2+-independent Group VI phospholipase A2s in P388D1 macrophages using GFP/RFP constructs

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1 reference

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25 November 2018

Identifiers

10.1021/ACS.JMEDCHEM.6B00377

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

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