(Q41217565)

28 September 2017

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title

The mechanisms of action of NSAIDs in analgesia (English)

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28 September 2017

J N Cashman

1

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28 September 2017

publication date

1 January 1996

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28 September 2017

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28 September 2017

volume

52 Suppl 5

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28 September 2017

page(s)

13-23

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Arachidonic acid metabolism, pain and hyperalgesia: the mode of action of non-steroid mild analgesics

28 September 2017

cites work

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12 December 2020

Characterization of the analgesic activity of ketorolac in mice

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12 December 2020

Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines

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12 December 2020

The Spinal Actions of Nonsteroidal Anti-Inflammatory Drugs and the Dissociation between their Anti-Inflammatory and Analgesic Effects

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12 December 2020

Prostaglandins, Aspirin-like Drugs and Analgesia

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12 December 2020

Inhibitory effects of diclofenac and indomethacin on interleukin-1-induced changes in PGE2 release. A novel effect on free arachidonic acid levels in human synovial cells

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12 December 2020

Stereoselective disposition of ibuprofen enantiomers in synovial fluid

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12 December 2020

Spectroscopic evidence for reaction of prostaglandin H synthase-1 tyrosyl radical with arachidonic acid.

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12 December 2020

Central antinociceptive effects of non-steroidal anti-inflammatory drugs and paracetamol. Experimental studies in the rat.

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12 December 2020

Enhancement by cyclo-oxygenase inhibitors of platelet-activating factor production in thapsigargin-stimulated macrophages

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12 December 2020

Diclofenac increases beta-endorphin plasma concentrations

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12 December 2020

Generation of acute pain: Central mechanism

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12 December 2020

Fatty acid cyclo-oxygenase inhibitors and the regulation of cerebral blood flow

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12 December 2020

Acetylation of prostaglandin synthase by aspirin

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12 December 2020

Modes of action of aspirin-like drugs

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12 December 2020

Diclofenac and pirprofen modify pituitary and hypothalamic beta-endorphin concentrations

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12 December 2020

Effect of aspirin on serotonin and met-enkephalin in brain: correlation with the antinociceptive activity of the drug.

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12 December 2020

Peripheral and spinal mechanisms of nociception

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12 December 2020

Some nonsteroidal antiinflammatory drugs inhibit the generation of superoxide anions by activated polymorphs by blocking ligand-receptor interactions

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12 December 2020

Topography of prostaglandin H synthase. Antiinflammatory agents and the protease-sensitive arginine 253 region.

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12 December 2020

International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes

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12 December 2020

[Effect of diclofenac on the opiate withdrawal syndrome]

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12 December 2020

Effects of the novel anti-inflammatory compounds, N-[2-(cyclohexyloxy)-4-nitrophenyl] methanesulphonamide (NS-398) and 5-methanesulphonamido-6-(2,4-difluorothio-phenyl)-1-inda none (L-745,337), on the cyclo-oxygenase activity of human blood prostagl

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12 December 2020

The mechanisms of action of nonsteroidal antiinflammatory drugs

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12 December 2020

Effects of peripherally and centrally acting analgesics on somato-sensory evoked potentials

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12 December 2020

Interactions between substance P, calcitonin gene-related peptide, taurine and excitatory amino acids in the spinal cord

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12 December 2020

Peripheral mechanisms of somatic pain

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12 December 2020

Inflammatory mediators of pain

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12 December 2020

Non-steroidal anti-inflammatory drugs and spinal nociceptive processing

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12 December 2020

Central and peripheral haemodynamic effects of non-steroidal anti-inflammatory drugs in man.

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12 December 2020

New molecules in analgesia

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12 December 2020

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

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12 December 2020

Prostaglandin biosynthesis: consequences of oxygenase mechanism upon in vitro assays of drug effectiveness

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12 December 2020

The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury.

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12 December 2020

Effect of diclofenac sodium on the arachidonic acid cascade

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12 December 2020

Non-steroidal anti-inflammatory drugs: rationale for use in severe postoperative pain

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12 December 2020

Acetylsalicylic acid, paracetamol and morphine inhibit behavioral responses to intrathecally administered substance P or capsaicin

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12 December 2020

Stoichiometry and kinetics of the interaction of prostaglandin H synthase with anti-inflammatory agents

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12 December 2020

Depression by morphine and the non-opioid analgesic agents, metamizol (dipyrone), lysine acetylsalicylate, and paracetamol, of activity in rat thalamus neurones evoked by electrical stimulation of nociceptive afferents

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12 December 2020

Antinociception produced by spinal delivery of the S and R enantiomers of flurbiprofen in the formalin test

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12 December 2020

Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain

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12 December 2020

Indomethacin and aspirin abolish prostaglandin release from the spleen

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12 December 2020

Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activity

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12 December 2020

Recent advances in the pathophysiology of acute pain

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12 December 2020

L-745,337: a selective inhibitor of cyclooxygenase-2 elicits antinociception but not gastric ulceration in rats

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12 December 2020

Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition

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12 December 2020

Peripheral analgesia: mechanism of the analgesic action of aspirin-like drugs and opiate-antagonists

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12 December 2020

Dissociation between the antinociceptive and anti-inflammatory effects of the nonsteroidal anti-inflammatory drugs. A survey of their analgesic efficacy

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12 December 2020

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase

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12 December 2020

NSAIDs, Cox-2 inhibitors, and the gut

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12 December 2020

Aspirin-like drugs may block pain independently of prostaglandin synthesis inhibition

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12 December 2020

Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs

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12 December 2020

The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein

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12 December 2020

Central effect of the non-steroid anti-inflammatory agents, indomethacin, ibuprofen, and diclofenac, determined in C fibre-evoked activity in single neurones of the rat thalamus.

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12 December 2020

Chemical activation of nociceptive peripheral neurones

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12 December 2020

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12 December 2020

Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation

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12 December 2020

Evidence for involvement of N-methylaspartate receptors in 'wind-up' of class 2 neurones in the dorsal horn of the rat.

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12 December 2020

The mode of action of anti-inflammatory drugs

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12 December 2020

Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs

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12 December 2020

Inhibition of prostaglandin synthesis in rat brain

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12 December 2020

The antinociceptive effect of S-(+)-ibuprofen in rabbits: epidural versus intravenous administration

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12 December 2020

Behavioural and electrophysiological evidence for an analgesic effect of a non-steroidal anti-inflammatory agent, sodium diclofenac

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12 December 2020

Towards a better aspirin

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12 December 2020

Cyclic AMP and the regulation of prostaglandin production by macrophages

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12 December 2020

Inflammation and hyperalgesia: highlighting the team effort

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12 December 2020

The value of pre-emptive analgesia in the treatment of postoperative pain

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12 December 2020

The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase

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12 December 2020

Evidence for a peroxide-initiated free radical mechanism of prostaglandin biosynthesis

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12 December 2020

Nonsteroidal antiinflammatory drugs--differences and similarities

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12 December 2020

Small Intrathecal Doses of Lysine-Acetylsalicylate Relieve Intractable Pain in Man

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12 December 2020

Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat

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12 December 2020

10.2165/00003495-199600525-00004

Identifiers

DOI

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