(Q41257654)

28 September 2017

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title

Pharmaceutical approach to somatic gene therapy (English)

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28 September 2017

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F D Ledley

1

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28 September 2017

publication date

1 November 1996

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28 September 2017

published in

Pharmaceutical Research

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28 September 2017

volume

13

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28 September 2017

issue

11

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28 September 2017

page(s)

1595-1614

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Cationic liposome-mediated intravenous gene delivery

28 September 2017

cites work

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12 December 2020

Use of a quaternary ammonium detergent in liposome mediated DNA transfection of mouse L-cells

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12 December 2020

Cellular and Molecular Barriers to Gene Transfer by a Cationic Lipid

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12 December 2020

Gene transfer into primary and established mammalian cell lines with lipopolyamine-coated DNA.

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12 December 2020

A novel cationic liposome reagent for efficient transfection of mammalian cells

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12 December 2020

Generation of novel, biologically active Harvey sarcoma viruses via apparent illegitimate recombination

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12 December 2020

Targeted gene transfer into hepatoma cells with lipopolyamine-condensed DNA particles presenting galactose ligands: a stage toward artificial viruses

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12 December 2020

Cyclic amphipathic peptide-DNA complexes mediate high-efficiency transfection of adherent mammalian cells

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12 December 2020

A novel mechanism for achieving transgene persistence in vivo after somatic gene transfer into hepatocytes

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12 December 2020

Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle

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12 December 2020

High-efficiency receptor-mediated delivery of small and large (48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles.

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12 December 2020

Integrin alpha v beta 5 selectively promotes adenovirus mediated cell membrane permeabilization.

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12 December 2020

Adenovirus-mediated augmentation of cell transfection with unmodified plasmid vectors

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12 December 2020

Conditions affecting direct gene transfer into rodent muscle in vivo

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12 December 2020

Targeting genes: delivery and persistent expression of a foreign gene driven by mammalian regulatory elements in vivo

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12 December 2020

Amphotropic murine leukemia retrovirus is not an acute pathogen for primates

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12 December 2020

Utilization of modified surfactant-associated protein B for delivery of DNA to airway cells in culture

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12 December 2020

Immunization with plasmid DNA using a pneumatic gun.

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12 December 2020

Use of the rabbit ear artery to serially assess foreign protein secretion after site-specific arterial gene transfer in vivo. Evidence that anatomic identification of successful gene transfer may underestimate the potential magnitude of transgene ex

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12 December 2020

Gene transfer into coronary arteries of intact animals with a percutaneous balloon catheter

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12 December 2020

No retroviremia or pathology in long-term follow-up of monkeys exposed to a murine amphotropic retrovirus

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12 December 2020

Gene transfer in vivo: sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake

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12 December 2020

Specific gene transfer mediated by lactosylated poly-L-lysine into hepatoma cells

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12 December 2020

Cationic lipids for reporter gene and CFTR transfer to rat pulmonary epithelium.

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12 December 2020

Correction of the enzyme deficiency in hematopoietic cells of Gaucher patients using a clinically acceptable retroviral supernatant transduction protocol

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12 December 2020

Recombinant fibroblast growth factor-1 promotes intimal hyperplasia and angiogenesis in arteries in vivo

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12 December 2020

Protection of rabbit lungs from endotoxin injury by in vivo hyperexpression of the prostaglandin G/H synthase gene

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12 December 2020

Polyvinyl derivatives as novel interactive polymers for controlled gene delivery to muscle

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12 December 2020

Combination gene therapy for liver metastasis of colon carcinoma in vivo

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12 December 2020

Receptor-mediated gene transfer into human T lymphocytes via binding of DNA/CD3 antibody particles to the CD3 T cell receptor complex.

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12 December 2020

Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses

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12 December 2020

Condensation of DNA by multivalent cations: Considerations on mechanism

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12 December 2020

Nonviral gene therapy: the promise of genes as pharmaceutical products

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12 December 2020

In vivo transfection of murine lungs with a functioning prokaryotic gene using a liposome vehicle.

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12 December 2020

No lung toxicity after repeated aerosol or intravenous delivery of plasmid-cationic liposome complexes

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12 December 2020

Intracellular immunization of human fetal cord blood stem/progenitor cells with a ribozyme against human immunodeficiency virus type 1.

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12 December 2020

Transfer and expression of the human multiple drug resistance gene in human CD34+ cells

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12 December 2020

Direct gene transfer into mouse diaphragm

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12 December 2020

Lipophilic polylysines mediate efficient DNA transfection in mammalian cells

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12 December 2020

Protection of retroviral vector particles in human blood through complement inhibition

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12 December 2020

Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans

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12 December 2020

Gene Transfer In Vivo with DNA–Liposome Complexes: Safety and Acute Toxicity in Mice

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12 December 2020

Expression of hepatitis B virus surface antigen in adult rat liver. Co-introduction of DNA and nuclear protein by a simplified liposome method

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12 December 2020

Gene therapy for cholesterol

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12 December 2020

Transduction of a foreign histocompatibility gene into the arterial wall induces vasculitis

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12 December 2020

Receptor-mediated endocytosis of transferrin-polycation conjugates: an efficient way to introduce DNA into hematopoietic cells

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12 December 2020

Adenovirus-dependent release of choline from plasma membrane vesicles at an acidic pH is mediated by the penton base protein

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12 December 2020

A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolaemia

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12 December 2020

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

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12 December 2020

Gene Therapy for Hemophilia B: Host Immunosuppression Prolongs the Therapeutic Effect of Adenovirus-Mediated Factor IX Expression

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12 December 2020

DNA condensation with polyamines. II. Electron microscopic studies

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12 December 2020

Gene Transfer to Synovial Cells by Intra-Articular Administration of Plasmid DNA

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12 December 2020

Expression of recombinant genes in myocardium in vivo after direct injection of DNA.

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12 December 2020

The glycophospholipid-linked folate receptor internalizes folate without entering the clathrin-coated pit endocytic pathway

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12 December 2020

Efficient gene transfer into nondividing cells by adeno-associated virus-based vectors.

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12 December 2020

Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis.

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12 December 2020

In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment

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12 December 2020

In vivo gene delivery. Efficient transfection of T lymphocytes in adult mice.

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12 December 2020

Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia

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12 December 2020

Retrovirus packaging cells.

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12 December 2020

Systemic gene therapy: biodistribution and long-term expression of a transgene in mice

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12 December 2020

Receptor-mediated gene delivery in vivo. Partial correction of genetic analbuminemia in Nagase rats

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12 December 2020

Recombinant platelet-derived growth factor B gene expression in porcine arteries induce intimal hyperplasia in vivo

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12 December 2020

Intratumoral injection of an adenovirus expressing interleukin 2 induces regression and immunity in a murine breast cancer model

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12 December 2020

Characterization of a replication-competent retrovirus resulting from recombination of packaging and vector sequences

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12 December 2020

In vivo evaluation of the safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lung.

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12 December 2020

Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer

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12 December 2020

Safety and toxicity of catheter gene delivery to the pulmonary vasculature in a patient with metastatic melanoma

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12 December 2020

Evaluation of the respiratory epithelium of normals and individuals with cystic fibrosis for the presence of adenovirus E1a sequences relevant to the use of E1a- adenovirus vectors for gene therapy for the respiratory manifestations of cystic fibros

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12 December 2020

Safety Issues Related to Retroviral-Mediated Gene Transfer in Humans

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12 December 2020

Developmental potential and dynamic behavior of hematopoietic stem cells.

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12 December 2020

Non-invasive liposome-mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice

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12 December 2020

Immune response to a carcinoembryonic antigen polynucleotide vaccine.

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12 December 2020

Adenovirus enhancement of transferrin-polylysine-mediated gene delivery

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12 December 2020

T lymphocyte-directed gene therapy for ADA- SCID: initial trial results after 4 years.

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12 December 2020

Expression of naked plasmids by cultured myotubes and entry of plasmids into T tubules and caveolae of mammalian skeletal muscle

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12 December 2020

MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses.

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12 December 2020

Direct gene transfer into mouse muscle in vivo

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12 December 2020

Aerosol and intravenous transfection of human alpha 1-antitrypsin gene to lungs of rabbits

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12 December 2020

Intratracheal gene delivery to the mouse airway: characterization of plasmid DNA expression and pharmacokinetics

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12 December 2020

Gene therapy by intramuscular injection of plasmid DNA: studies on firefly luciferase gene expression in mice

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12 December 2020

Optimization of cationic lipid-mediated gene transfer to airway epithelia

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12 December 2020

In vivo expression of rat insulin after intravenous administration of the liposome-entrapped gene for rat insulin I.

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12 December 2020

Deoxyribonucleic acid-mediated gene transfer in mammalian cells: molecular analysis of unstable transformants and their progression to stability

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12 December 2020

Synthesis and characterization of a trigalactosylated bisacridine compound to target DNA to hepatocytes.

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12 December 2020

Hepatic binding of DNA is mediated by a receptor on nonparenchymal cells.

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12 December 2020

Gene transfer optimization with lipospermine-coated DNA.

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12 December 2020

Effect of cationic cholesterol derivatives on gene transfer and protein kinase C activity

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12 December 2020

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity

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12 December 2020

Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis.

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12 December 2020

An improved system for packaging recombinant adeno-associated virus vectors capable of in vivo transduction.

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12 December 2020

Gene transfer in vivo with DNA-liposome complexes: lack of autoimmunity and gonadal localization

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12 December 2020

Evidence for targeted gene delivery to Hep G2 hepatoma cells in vitro

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12 December 2020

Cationic liposomes enhance targeted delivery and expression of exogenous DNA mediated by N-terminal modified poly(L-lysine)-antibody conjugate in mouse lung endothelial cells

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12 December 2020

Adenovirally mediated gene transfer into experimental solid brain tumors and leptomeningeal cancer cells.

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12 December 2020

Characterization of plasmid DNA transfer into mouse skeletal muscle: evaluation of uptake mechanism, expression and secretion of gene products into blood.

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12 December 2020

Retroviral mediated transfer of the human multidrug resistance gene (MDR-1) into hematopoietic stem cells during autologous transplantation after intensive chemotherapy for metastatic breast cancer

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12 December 2020

Gene transfer to respiratory epithelial cells via the receptor-mediated endocytosis pathway

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12 December 2020

Receptor-mediated gene delivery and expression in vivo.

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12 December 2020

Binding of double-stranded DNA to glomeruli of rats in vivo

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12 December 2020

Use of safety-modified retroviruses to introduce chemotherapy resistance sequences into normal hematopoietic cells for chemoprotection during the therapy of ovarian cancer: a pilot trial.

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12 December 2020

Recombinant IL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung.

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12 December 2020

Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle

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12 December 2020

Safety and efficacy of repetitive adenovirus-mediated transfer of CFTR cDNA to airway epithelia of primates and cotton rats.

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12 December 2020

A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis

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12 December 2020

Hepatocyte-directed gene transfer in vivo leads to transient improvement of hypercholesterolemia in low density lipoprotein receptor-deficient rabbits

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12 December 2020

Increased expression of DNA cointroduced with nuclear protein in adult rat liver

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12 December 2020

Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy

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12 December 2020

Role of nuclear trafficking in regulating cellular activity

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12 December 2020

Gene transfer into somatic tissues by jet injection

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12 December 2020

Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression

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12 December 2020

Receptor-mediated gene transfer to airway epithelial cells in primary culture

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12 December 2020

Hepatic gene therapy: adenovirus enhancement of receptor-mediated gene delivery and expression in primary hepatocytes

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12 December 2020

Targeted transfection and expression of hepatitis B viral DNA in human hepatoma cells

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12 December 2020

DNA transfection mediated by cationic liposomes containing lipopolylysine: characterization and mechanism of action

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12 December 2020

Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes

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12 December 2020

Cancer Gene Therapy Using Plasmid DNA: Pharmacokinetic Study of DNA Following Injection in Mice

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12 December 2020

Introduction of foreign genes into tissues of living mice by DNA-coated microprojectiles

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12 December 2020

Pharmacological enhancement of in vivo foreign gene expression in muscle

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12 December 2020

pH-sensitive immunoliposomes mediate target-cell-specific delivery and controlled expression of a foreign gene in mouse

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12 December 2020

High-efficiency transfection of primary human keratinocytes with positively charged lipopolyamine:DNA complexes.

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12 December 2020

Efficient transfer and sustained high expression of the human glucocerebrosidase gene in mice and their functional macrophages following transplantation of bone marrow transduced by a retroviral vector

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12 December 2020

Cationic liposome-mediated transfection.

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12 December 2020

Direct injection of hepatitis B virus DNA into liver induced hepatitis in adult rats

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12 December 2020

The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems.

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12 December 2020

Direct myocardial transfection in two animal models. Evaluation of parameters affecting gene expression and percutaneous gene delivery

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12 December 2020

Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vector

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12 December 2020

Prospects for the use of adeno-associated virus as a vector for human gene therapy

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12 December 2020

Gene expression following direct injection of DNA into liver

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12 December 2020

Direct in vivo gene transfer into the coronary and peripheral vasculatures of the intact dog.

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12 December 2020

Direct gene transfer and expression into rat heart in vivo

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12 December 2020

Safety aspects of gene therapy

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12 December 2020

Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency

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12 December 2020

Systemic gene expression after intravenous DNA delivery into adult mice

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12 December 2020

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine

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12 December 2020

Chimerasome-mediated gene transfer in vitro and in vivo

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12 December 2020

Analysis of optimal conditions for retroviral-mediated transduction of primitive human hematopoietic cells

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12 December 2020

Long-term anti-nucleoprotein cellular and humoral immunity is induced by intramuscular injection of plasmid DNA containing NP gene

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12 December 2020

A novel mechanism of retrovirus inactivation in human serum mediated by anti-alpha-galactosyl natural antibody

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12 December 2020

Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo

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12 December 2020

Gene therapy in peripheral blood lymphocytes and bone marrow for ADA- immunodeficient patients

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12 December 2020

Acute responses of non-human primates to airway delivery of an adenovirus vector containing the human cystic fibrosis transmembrane conductance regulator cDNA.

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12 December 2020

Retroviral vector-mediated gene transfer into primitive human hematopoietic progenitor cells: effects of mast cell growth factor (MGF) combined with other cytokines

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12 December 2020

High-efficiency gene transfer mediated by adenovirus coupled to DNA-polylysine complexes

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12 December 2020

Fate of DNA targeted to the liver by asialoglycoprotein receptor-mediated endocytosis in vivo. Prolonged persistence in cytoplasmic vesicles after partial hepatectomy

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12 December 2020

Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand.

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12 December 2020

Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells

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12 December 2020

Carbohydrate receptor-mediated gene transfer to human T leukaemic cells

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12 December 2020

Delivery of folates to the cytoplasm of MA104 cells is mediated by a surface membrane receptor that recycles

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12 December 2020

In vivo promoter activity and transgene expression in mammalian somatic tissues evaluated by using particle bombardment

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12 December 2020

Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses

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12 December 2020

Expression of the human cystic fibrosis transmembrane conductance regulator gene in the mouse lung after in vivo intratracheal plasmid-mediated gene transfer

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12 December 2020

Plasmid DNA is superior to viral vectors for direct gene transfer into adult mouse skeletal muscle

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12 December 2020

Hepatic gene therapy: efficient gene delivery and expression in primary hepatocytes utilizing a conjugated adenovirus-DNA complex

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12 December 2020

Adenovirus-mediated gene transfer for cystic fibrosis: quantitative evaluation of repeated in vivo vector administration to the lung

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12 December 2020

Stepwise dismantling of adenovirus 2 during entry into cells

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12 December 2020

Direct transfection of viral and plasmid DNA into the liver or spleen of mice

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12 December 2020

The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer

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12 December 2020

Direct gene transfer into skeletal muscle in vivo: factors affecting efficiency of transfer and stability of expression

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12 December 2020

Mechanisms of DNA uptake by mammalian cells: fate of exogenously added DNA monitored by the use of fluorescent dyes

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12 December 2020

Aerosol gene delivery in vivo

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12 December 2020

Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations

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12 December 2020

Nasal application of the cationic liposome DC-Chol:DOPE does not alter ion transport, lung function or bacterial growth

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12 December 2020

Polyamidoamine cascade polymers mediate efficient transfection of cells in culture

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12 December 2020

The fate of plasmid DNA after intravenous injection in mice: involvement of scavenger receptors in its hepatic uptake

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12 December 2020

Characterization of replication-competent retroviruses from nonhuman primates with virus-induced T-cell lymphomas and observations regarding the mechanism of oncogenesis

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12 December 2020

Systemic gene therapy with p53 reduces growth and metastases of a malignant human breast cancer in nude mice

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12 December 2020

Nucleocytoplasmic transport

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12 December 2020

Retroviral-mediated transfer of the human glucocerebrosidase gene into cultured Gaucher bone marrow

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12 December 2020

Delivery of plasmid DNA into mammalian cell lines using pH-sensitive liposomes: comparison with cationic liposomes

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12 December 2020

Chicken adenovirus (CELO virus) particles augment receptor-mediated DNA delivery to mammalian cells and yield exceptional levels of stable transformants

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12 December 2020

Retrovirus Transduction: Generation of Infectious Retroviruses Expressing Dominant and Selectable Genes Is Associated with In Vivo Recombination and Deletion Events

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12 December 2020

pH-dependent lysis of liposomes by adenovirus.

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12 December 2020

Plasmid DNA entry into postmitotic nuclei of primary rat myotubes

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12 December 2020

Overexpression of human methylmalonyl CoA mutase in mice after in vivo gene transfer with asialoglycoprotein/polylysine/DNA complexes

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12 December 2020

Rhinovirus-mediated endosomal release of transfection complexes

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12 December 2020

Transferrin-polycation conjugates as carriers for DNA uptake into cells

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12 December 2020

Gene Transfer into Human Hematopoietic Progenitor Cells: A Review of Current Clinical Protocols

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12 December 2020

Behavior of genes directly injected into the rat heart in vivo

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12 December 2020

Mechanisms of DNA entry into mammalian cells. II. Phagocytosis of calcium phosphate DNA co-precipitate visualized by electron microscopy

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12 December 2020

Polyelectrolyte effects in DNA condensation by polyamines.

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12 December 2020

Clearance of human antibody/DNA immune complexes and free DNA from the circulation of the nonhuman primate

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12 December 2020

Compact form of DNA induced by spermidine

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12 December 2020

Safety and short-term toxicity of a novel cationic lipid formulation for human gene therapy

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12 December 2020

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure

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12 December 2020

Incorporation of adenovirus into a ligand-based DNA carrier system results in retention of original receptor specificity and enhances targeted gene expression

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12 December 2020

Microtubular disruption prolongs the expression of human bilirubin-uridinediphosphoglucuronate-glucuronosyltransferase-1 gene transferred into Gunn rat livers

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12 December 2020

Receptor-mediated in vitro gene transformation by a soluble DNA carrier system

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12 December 2020

Cancer Gene Therapy Using Plasmid DNA: Safety Evaluation in Rodents and Non-Human Primates

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12 December 2020

Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA.

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12 December 2020

Gene transfer with a series of lipophilic DNA-binding molecules

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12 December 2020

Highly efficient DNA delivery mediated by pH-sensitive immunoliposomes

1 reference

12 December 2020

Folate receptor mediated DNA delivery into tumor cells: potosomal disruption results in enhanced gene expression

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12 December 2020

Circumvention of chemotherapy-induced myelosuppression by transfer of the mdr1 gene

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12 December 2020

Improved gene transfer by direct plasmid injection associated with regeneration in mouse skeletal muscle.

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12 December 2020

Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis

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12 December 2020

Expression of human growth hormone fusion genes in cultured lung endothelial cells and in the lungs of mice

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12 December 2020

Phase I Study of Cellular Adoptive Immunotherapy Using Genetically Modified CD8+ HIV-Specific T Cells for HIV Seropositive Patients Undergoing Allogeneic Bone Marrow Transplant. Fred Hutchinson Cancer Research Center and the University of Washington

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12 December 2020

Liposome-mediated in vivo E1A gene transfer suppressed dissemination of ovarian cancer cells that overexpress HER-2/neu

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12 December 2020

Arterial gene transfer using pure DNA applied directly to a hydrogel-coated angioplasty balloon

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12 December 2020

In vivo gene transfer into rabbit thyroid follicular cells by direct DNA injection

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12 December 2020

Immunologic consequences of nucleic acid therapy

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12 December 2020

Adeno-associated virus vectors preferentially transduce cells in S phase.

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12 December 2020

Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia

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12 December 2020

In vivo molecular therapy with p53 adenovirus for microscopic residual head and neck squamous carcinoma

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12 December 2020

Immunotherapy of malignancy by in vivo gene transfer into tumors

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12 December 2020

Association of a pH-sensitive peptide with membrane vesicles: role of amino acid sequence

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12 December 2020

Safety considerations in somatic gene therapy of human disease with retrovirus vectors

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12 December 2020

Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA.

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12 December 2020

Cholesterol enhances cationic liposome-mediated DNA transfection of human respiratory epithelial cells

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12 December 2020

Identifiers

DOI

10.1023/A:1016420102549

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28 September 2017

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