(Q41263199)

28 September 2017

Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche (English)

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28 September 2017

1 reference

21

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28 September 2017

Mukesh Bansal

3

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Chiara Bardella

Chiara Bardella

6

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Annabelle Lewis

Annabelle Lewis

8

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Florian Greten

Florian R Greten

22

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Manuel Rodriguez-Justo

Manuel Rodriguez-Justo

17

0 references

Ian Tomlinson

25

Ian Tomlinson

1 reference

28 September 2017

Francesc Castro-giner

10

Francesc Castro Giner

1 reference

28 September 2017

Hayley Davis

1

1 reference

28 September 2017

Shazia Irshad

2

1 reference

28 September 2017

Hannah Rafferty

4

1 reference

28 September 2017

Tatjana Boitsova

5

1 reference

28 September 2017

Emma Jaeger

7

1 reference

28 September 2017

Luke Freeman-Mills

9

1 reference

28 September 2017

Pedro Rodenas-Cuadrado

11

1 reference

28 September 2017

Sreelakshmi Mallappa

12

1 reference

28 September 2017

Susan Clark

13

1 reference

28 September 2017

Huw Thomas

14

1 reference

28 September 2017

Rosemary Jeffery

15

1 reference

28 September 2017

Richard Poulsom

16

1 reference

28 September 2017

Marco Novelli

18

1 reference

28 September 2017

Runjan Chetty

19

1 reference

28 September 2017

Andrew Silver

20

1 reference

28 September 2017

Lai Mun Wang

23

1 reference

28 September 2017

James Edward East

24

1 reference

28 September 2017

Simon John Leedham

26

1 reference

28 September 2017

language of work or name

English

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publication date

1 December 2014

1 reference

28 September 2017

1 reference

28 September 2017

21

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28 September 2017

1

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28 September 2017

62-70

1 reference

describes a project that uses

28 September 2017

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/4594755

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/nm.3750

0 references

cites work

A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

Unravelling mechanisms of p53-mediated tumour suppression

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

Long-lived intestinal tuft cells serve as colon cancer-initiating cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

Drugging a stem cell compartment using Wnt3a protein as a therapeutic

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

A comprehensive review of reported heritable noggin-associated syndromes and proposed clinical utility of one broadly inclusive diagnostic term: NOG-related-symphalangism spectrum disorder (NOG-SSD).

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

Autophagy in tumour suppression and promotion

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

Crypt stem cells as the cells-of-origin of intestinal cancer

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

Bone morphogenetic protein signalling in colorectal cancer.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

Current view: intestinal stem cells and signaling

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

Identification of stem cells in small intestine and colon by marker gene Lgr5

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

Conditional deletion of gremlin causes a transient increase in bone formation and bone mass

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

The morphogenetic code and colon cancer development

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

Top-down morphogenesis of colorectal tumors

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

A genetic model for colorectal tumorigenesis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

A simple device to rapidly prepare whole mounts of murine intestine.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

Bmp signaling is required for intestinal growth and morphogenesis.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4594755

Clinical and molecular features of the hereditary mixed polyposis syndrome

19 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.3750

Loss of Apc+ in intestinal adenomas from Min mice

21 January 2018

1 reference

12 December 2020

Sessile serrated adenoma (SSA) vs. traditional serrated adenoma (TSA)

1 reference

12 December 2020

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

1 reference

12 December 2020

Reply to "The classification of intestinal polyposis"

1 reference

12 December 2020

Bottom-up histogenesis of colorectal adenomas: origin in the monocryptal adenoma and initial expansion by crypt fission

1 reference

12 December 2020

Identifiers

DOI

10.1038/NM.3750

1 reference

28 September 2017

1 reference

28 September 2017

1 reference