(Q41272416)

English

The phosphodiesterase inhibitor SQ 20006 selectively blocks mitogen activation of p70S6k and transition to S phase of the cell division cycle without affecting the steady state phosphorylation of eIF-4E.

scientific article published on November 1995

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scholarly article

1 reference

Europe PubMed Central

29 September 2017

The phosphodiesterase inhibitor SQ 20006 selectively blocks mitogen activation of p70S6k and transition to S phase of the cell division cycle without affecting the steady state phosphorylation of eIF-4E. (English)

1 reference

Europe PubMed Central

29 September 2017

phosphorylation

1 reference

based on heuristic

inferred from title

Stefano Ferrari

6

1 reference

Europe PubMed Central

29 September 2017

author name string

Frost V

1

1 reference

Europe PubMed Central

29 September 2017

Morley SJ

2

1 reference

Europe PubMed Central

29 September 2017

Mercep L

3

1 reference

Europe PubMed Central

29 September 2017

Meyer T

4

1 reference

Europe PubMed Central

29 September 2017

Fabbro D

5

1 reference

Europe PubMed Central

29 September 2017

language of work or name

0 references

publication date

1 November 1995

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Europe PubMed Central

29 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

29 September 2017

270

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Europe PubMed Central

29 September 2017

26698-26706

1 reference

Europe PubMed Central

29 September 2017

44

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Europe PubMed Central

29 September 2017

Dimerization of cell surface receptors in signal transduction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

MAP kinase pathways. Straight and narrow or tortuous and intersecting?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Continuous protein synthesis is required to maintain the probability of entry into S phase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Intracellular messengers and the control of protein synthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Regulation of translation and cell growth by eIF-4E.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

S6 phosphorylation and the p70s6k/p85s6k

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Activation of p70s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Multiple independent inputs are required for activation of the p70 S6 kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Activation of p70/p85 S6 kinase by a pathway independent of p21ras

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

PHAS-I as a link between mitogen-activated protein kinase and translation initiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Interaction between the cell-cycle-control proteins p34cdc2 and p9CKShs2. Evidence for two cooperative binding domains in p9CKShs2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

S6 kinase in quiescent Swiss mouse 3T3 cells is activated by phosphorylation in response to serum treatment

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Increased phosphorylation of eukaryotic initiation factor 4 alpha during early activation of T lymphocytes correlates with increased initiation factor 4F complex formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Micro- and macropurification methods for protein kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

1-Ethyl-4-(isopropylidenehydrazino)-1H-pyrazolo-(3,4-b)-pyridine-5-carboxylic acid, ethyl ester, hydrochloride (SQ 20009)--a potent new inhibitor of cyclic 3',5'-nucleotide phosphodiesterases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Regulation of 40S ribosomal protein S6 phosphorylation in Swiss mouse 3T3 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Inhibition of cyclin-dependent kinases by purine analogues.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

G1 events and regulation of cell proliferation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Cyclic AMP-dependent protein kinase phosphorylates rabbit reticulocyte elongation factor-2 kinase and induces calcium-independent activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Isolation and characterization of yeast mutants deficient in adenylate cyclase and cAMP-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Protein kinase A acts at multiple points to inhibit Xenopus oocyte maturation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Inhibition by cAMP of Ras-dependent activation of Raf.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

[4] Preparation and use of nuclease-treated rabbit reticulocyte lysates for the translation of eukaryotic messenger RNA

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

p70s6k function is essential for G1 progression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Turned on by insulin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Modular binding domains in signal transduction proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Signal transduction mechanisms in the regulation of protein synthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

EGF induces biphasic S6 kinase activation: late phase is protein kinase C-dependent and contributes to mitogenicity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.44.26698

21 January 2018

Identifiers

10.1074/JBC.270.44.26698

1 reference

Europe PubMed Central

29 September 2017

1 reference

Europe PubMed Central

29 September 2017

ResearchGate publication ID

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