(Q41317435)

29 September 2017

The fetal mouse is a sensitive genotoxicity model that exposes lentiviral-associated mutagenesis resulting in liver oncogenesis (English)

1 reference

29 September 2017

1 reference

7

1 reference

29 September 2017

10

Christof von Kalle

1 reference

29 September 2017

Wing T Cheung

2

0 references

Faisal A Al-Allaf

Faisal Al-Allaf

12

0 references

Eugenio Montini

Eugenio Montini

20

0 references

Brian Bigger

Brian Bigger

19

0 references

Lisa Gregory

Lisa Gregory

13

0 references

Adrian Thrasher

Adrian J Thrasher

21

0 references

Manfred Schmidt

26

Manfred Schmidt

1 reference

29 September 2017

Ali Nowrouzi

1

1 reference

29 September 2017

Tingting Li

3

1 reference

29 September 2017

Xuegong Zhang

4

1 reference

29 September 2017

Anne Arens

5

1 reference

29 September 2017

Anna Paruzynski

6

1 reference

29 September 2017

Emma Osejindu

8

1 reference

29 September 2017

Safia Reja

9

1 reference

29 September 2017

Yoahe Wang

11

1 reference

29 September 2017

Matthew Themis

14

1 reference

29 September 2017

Maxine Holder

15

1 reference

29 September 2017

Niraja Dighe

16

1 reference

29 September 2017

Alaine Ruthe

17

1 reference

29 September 2017

Suzanne Mk Buckley

18

1 reference

29 September 2017

Robert Andrews

22

1 reference

29 September 2017

Terry P Roberts

23

1 reference

29 September 2017

Robert F Newbold

24

1 reference

29 September 2017

Charles Coutelle

25

1 reference

29 September 2017

Mike Themis

27

1 reference

29 September 2017

13 November 2012

1 reference

29 September 2017

1 reference

29 September 2017

21

1 reference

29 September 2017

2

1 reference

29 September 2017

324-337

1 reference

describes a project that uses

29 September 2017

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/3594025

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

Lentivirus-mediated reprogramming of somatic cells in the absence of transgenic transcription factors

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

Complex exon-intron marking by histone modifications is not determined solely by nucleosome distribution

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

Validation of a mutated PRE sequence allowing high and sustained transgene expression while abrogating WHV-X protein synthesis: application to the gene therapy of WAS.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

Multi-stage analysis of gene expression and transcription regulation in C57/B6 mouse liver development.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

UVRAG: a new player in autophagy and tumor cell growth

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

The integration profile of EIAV-based vectors

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

Genotoxicity of retroviral integration in hematopoietic cells.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

A role for LEDGF/p75 in targeting HIV DNA integration

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

Gene expression levels assessed by oligonucleotide microarray analysis and quantitative real-time RT-PCR -- how well do they correlate?

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

Prolonged liver-specific transgene expression by a non-primate lentiviral vector

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

Transcription start regions in the human genome are favored targets for MLV integration

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

Side effects of retroviral gene transfer into hematopoietic stem cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

HIV-1 integration in the human genome favors active genes and local hotspots

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

New methods to titrate EIAV-based lentiviral vectors

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

A new mathematical model for relative quantification in real-time RT-PCR

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

Stable gene transfer to the nervous system using a non-primate lentiviral vector

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

Gene transfer vectors derived from equine infectious anemia virus

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

Clonality analysis after retroviral-mediated gene transfer to CD34+ cells from the cord blood of ADA-deficient SCID neonates

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

[The expression of DJ-1 gene in human hepatocellular carcinoma and its relationship with tumor invasion and metastasis].

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

Potential oncogene activity of the woodchuck hepatitis post-transcriptional regulatory element (WPRE).

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

Long-term transgene expression by administration of a lentivirus-based vector to the fetal circulation of immuno-competent mice.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

Polyclonal long-term repopulating stem cell clones in a primate model

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594025

19 August 2018

Identifiers

DOI

10.1038/MT.2012.224

1 reference

29 September 2017

1 reference

29 September 2017

PubMed publication ID

23299800

1 reference