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A monomeric derivative of the cellular transcription factor CREB functions as a constitutive activator.
scientific article published on November 1994
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PMCID
359254
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7935435%20AND%20SRC:MED&resulttype=core&format=json
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28 October 2019
title
A monomeric derivative of the cellular transcription factor CREB functions as a constitutive activator
(English)
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Europe PubMed Central
PMCID
359254
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7935435%20AND%20SRC:MED&resulttype=core&format=json
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28 October 2019
author
Władysław Krajewski
series ordinal
1
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Europe PubMed Central
PMCID
359254
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7935435%20AND%20SRC:MED&resulttype=core&format=json
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28 October 2019
author name string
K A Lee
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2
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Europe PubMed Central
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359254
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7935435%20AND%20SRC:MED&resulttype=core&format=json
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28 October 2019
language of work or name
English
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publication date
1 November 1994
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359254
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28 October 2019
published in
Molecular and Cellular Biology
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Europe PubMed Central
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359254
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7935435%20AND%20SRC:MED&resulttype=core&format=json
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28 October 2019
volume
14
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Europe PubMed Central
PMCID
359254
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7935435%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 October 2019
page(s)
7204-7210
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Europe PubMed Central
PMCID
359254
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7935435%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 October 2019
issue
11
1 reference
stated in
Europe PubMed Central
PMCID
359254
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7935435%20AND%20SRC:MED&resulttype=core&format=json
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28 October 2019
cites work
The functional versatility of CREM is determined by its modular structure.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Phosphorylated CREB binds specifically to the nuclear protein CBP
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Transcriptional regulation by CREB and its relatives
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
The cAMP response element binding protein, CREB, is a potent inhibitor of diverse transcriptional activators
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Nitrophenyl-EGTA, a photolabile chelator that selectively binds Ca2+ with high affinity and releases it rapidly upon photolysis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
The cAMP-regulated transcription factor CREB interacts with a component of the TFIID complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Identification of proteins that interact with CREB during differentiation of F9 embryonal carcinoma cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
How eukaryotic transcriptional activators work
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Scissors-grip model for DNA recognition by a family of leucine zipper proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Regulation of transcription by cyclic AMP-dependent protein kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Synergistic activation by the glutamine-rich domains of human transcription factor Sp1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Differential transcriptional activation by Oct-1 and Oct-2: interdependent activation domains induce Oct-2 phosphorylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Dimers, leucine zippers and DNA-binding domains
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Cyclic-AMP-responsive transcriptional activation of CREB-327 involves interdependent phosphorylated subdomains
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
The cellular transcription factor CREB corresponds to activating transcription factor 47 (ATF-47) and forms complexes with a group of polypeptides related to ATF-43.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Synergistic activation of eukaryotic transcription: the multiacceptor target hypothesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Synergistic transcriptional enhancement does not depend on the number of acidic activation domains bound to the promoter
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
TGF-beta 1 induces phosphorylation of the cyclic AMP responsive element binding protein in ML-CCl64 cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Promoter-selective activation domains in Oct-1 and Oct-2 direct differential activation of an snRNA and mRNA promoter
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Characterization of motifs which are critical for activity of the cyclic AMP-responsive transcription factor CREB
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Identification and functional characterisation of the cellular activating transcription factor 43 (ATF-43) protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
cAMP response element-binding protein is activated by Ca2+/calmodulin- as well as cAMP-dependent protein kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Structure of the leucine zipper
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Alternative usage of initiation codons in mRNA encoding the cAMP-responsive-element modulator generates regulators with opposite functions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Multiple mRNA isoforms of the transcription activator protein CREB: generation by alternative splicing and specific expression in primary spermatocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Conserved motifs in Fos and Jun define a new class of activation domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Dimeric transcription factor families: it takes two to tango but who decides on partners and the venue?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Developmental switch of CREM function during spermatogenesis: from antagonist to activator
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
The LIM family transcription factor Isl-1 requires cAMP response element binding protein to promote somatostatin expression in pancreatic islet cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Cyclic AMP response element-binding protein and the catalytic subunit of protein kinase A are present in F9 embryonal carcinoma cells but are unable to activate the somatostatin promoter
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
1 October 2017
Distinct activation domains within cAMP response element-binding protein (CREB) mediate basal and cAMP-stimulated transcription.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
11 June 2018
How different eukaryotic transcriptional activators can cooperate promiscuously.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
11 June 2018
A mechanism for synergistic activation of a mammalian gene by GAL4 derivatives.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
11 June 2018
Regulation of the pituitary-specific homeobox gene GHF1 by cell-autonomous and environmental cues.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
11 June 2018
A cyclic AMP response element mediates repression of tyrosine aminotransferase gene transcription by the tissue-specific extinguisher locus Tse-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
11 June 2018
Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
11 June 2018
CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
11 June 2018
Regulation of cyclic AMP response element-binding protein (CREB) phosphorylation by acute and chronic morphine in the rat locus coeruleus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
11 June 2018
A synergistic increase in potency of a multimerized VP16 transcriptional activation domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
11 June 2018
Phosphorylation of CREB affects its binding to high and low affinity sites: implications for cAMP induced gene transcription
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
11 June 2018
Protein-DNA interactions: how GCN4 binds DNA.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
19 August 2018
Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=359254
retrieved
19 August 2018
Identification of a region in the human vasoactive intestinal polypeptide gene responsible for regulation by cyclic AMP
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/7935435
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Eukaryotic activators function during multiple steps of preinitiation complex assembly
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/7935435
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Cyclic AMP responsiveness of human gonadotropin-alpha gene transcription is directed by a repeated 18-base pair enhancer. Alpha-promoter receptivity to the enhancer confers cell-preferential expression
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/7935435
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1128/MCB.14.11.7204
1 reference
stated in
Europe PubMed Central
PMCID
359254
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7935435%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 October 2019
PMCID
359254
1 reference
stated in
Europe PubMed Central
PMCID
359254
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7935435%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 October 2019
PubMed ID
7935435
1 reference
stated in
Europe PubMed Central
PMCID
359254
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7935435%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 October 2019
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