(Q41434730)

English

Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts

scientific article published on 30 July 2013

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scholarly article

1 reference

Europe PubMed Central

30 September 2017

Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts (English)

1 reference

Europe PubMed Central

30 September 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Holly Van Remmen

6

object named as

Holly Van Remmen

1 reference

Europe PubMed Central

30 September 2017

author name string

Chad Lerner

1

1 reference

Europe PubMed Central

30 September 2017

Alessandro Bitto

2

1 reference

Europe PubMed Central

30 September 2017

Daniel Pulliam

3

1 reference

Europe PubMed Central

30 September 2017

Timothy Nacarelli

4

1 reference

Europe PubMed Central

30 September 2017

Mina Konigsberg

5

1 reference

Europe PubMed Central

30 September 2017

Claudio Torres

7

1 reference

Europe PubMed Central

30 September 2017

Christian Sell

8

1 reference

Europe PubMed Central

30 September 2017

publication date

30 July 2013

1 reference

Europe PubMed Central

30 September 2017

1 reference

Europe PubMed Central

30 September 2017

12

1 reference

Europe PubMed Central

30 September 2017

6

1 reference

Europe PubMed Central

30 September 2017

966-977

1 reference

Europe PubMed Central

30 September 2017

Mitochondrial SKN-1/Nrf mediates a conserved starvation response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

Axis of ageing: telomeres, p53 and mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

Elimination of proliferating cells unmasks the shift from senescence to quiescence caused by rapamycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

p62 is a key regulator of nutrient sensing in the mTORC1 pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

Autophagy impairment induces premature senescence in primary human fibroblasts.

1 reference

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1 October 2017

Pleiotropic effects of growth hormone signaling in aging

1 reference

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1 October 2017

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

Mitochondrial fusion and fission in cell life and death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

Long-term IGF-I exposure decreases autophagy and cell viability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

Mitochondrial targeting of the electrophilic lipid 15-deoxy-Delta12,14-prostaglandin J2 increases apoptotic efficacy via redox cell signalling mechanisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

Transcriptional control of mitochondrial biogenesis and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

p62 at the crossroads of autophagy, apoptosis, and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

Molecular mechanisms of mTOR-mediated translational control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

Autophagy mediates the mitotic senescence transition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

Transcriptional paradigms in mammalian mitochondrial biogenesis and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

Proteasome modulates mitochondrial function during cellular senescence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

Mitochondrial retrograde signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

Nrf2-Keap1 defines a physiologically important stress response mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

Telomere measurement by quantitative PCR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

1 October 2017

The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor

1 reference

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1 October 2017

The mitochondrial genotype can influence nuclear gene expression in yeast.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

11 June 2018

Measuring mRNA decay in human mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5559196

19 August 2018

A stochastic model of cell replicative senescence based on telomere shortening, oxidative stress, and somatic mutations in nuclear and mitochondrial DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/23795962

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial dysfunction leads to telomere attrition and genomic instability

1 reference

https://pubmed.ncbi.nlm.nih.gov/23795962

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/ACEL.12122

1 reference

Europe PubMed Central

30 September 2017

1 reference

Europe PubMed Central

30 September 2017

1 reference

Europe PubMed Central

30 September 2017

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