(Q41460544)

1 October 2017

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title

Immunoallergic drug-induced hepatitis: lessons from halothane (English)

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1 October 2017

main subject

drug-induced hepatitis

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J G Kenna

1

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1 October 2017

publication date

1 January 1997

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1 October 2017

published in

Journal of Hepatology

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1 October 2017

volume

26 Suppl 1

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1 October 2017

page(s)

5-12

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Unexplained hepatitis following halothane

1 October 2017

cites work

1 reference

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7 January 2021

Antibodies to the surface of halothane-altered rabbit hepatocytes in patients with severe halothane-associated hepatitis

1 reference

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7 January 2021

Evidence for expression in human liver of halothane-induced neoantigens recognized by antibodies in sera from patients with halothane hepatitis

1 reference

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7 January 2021

Formation of trifluoroacetylated protein antigens in cultured rat hepatocytes exposed to halothane in vitro.

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7 January 2021

The topography of trifluoroacetylated protein antigens in liver microsomal fractions from halothane treated rats

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7 January 2021

Identification of the enzyme responsible for oxidative halothane metabolism: implications for prevention of halothane hepatitis

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7 January 2021

Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis.

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7 January 2021

Effect of fasting and obesity in humans on the 6-hydroxylation of chlorzoxazone: a putative probe of CYP2E1 activity.

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7 January 2021

Detection of autoantibodies directed against human hepatic endoplasmic reticulum in sera from patients with halothane-associated hepatitis

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7 January 2021

Autoantibodies to hepatic microsomal carboxylesterase in halothane hepatitis

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7 January 2021

Drug-protein conjugation and its immunological consequences

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7 January 2021

Halothane metabolism: the dihydrolipoamide acetyltransferase subunit of the pyruvate dehydrogenase complex molecularly mimics trifluoroacetyl-protein adducts

1 reference

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7 January 2021

The lipoic acid containing components of the 2-oxoacid dehydrogenase complexes mimic trifluoroacetylated proteins and are autoantigens associated with halothane hepatitis

1 reference

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7 January 2021

Molecular mimicry of trifluoroacetylated human liver protein adducts by constitutive proteins and immunochemical evidence for its impairment in halothane hepatitis

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7 January 2021

The retention signal for soluble proteins of the endoplasmic reticulum

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7 January 2021

Enflurane hepatotoxicity. A clinicopathologic study of 24 cases

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7 January 2021

Enflurane metabolism produces covalently bound liver adducts recognized by antibodies from patients with halothane hepatitis.

1 reference

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7 January 2021

Immunoglobulin A antibody to a 200-kilodalton cytosolic acetaldehyde adduct in alcoholic hepatitis

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7 January 2021

Cytochrome P4502E1 hydroxyethyl radical adducts as the major antigen in autoantibody formation among alcoholics

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7 January 2021

Antibody mediated hepatocyte injury in methyl dopa induced hepatotoxicity

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7 January 2021

Immune mechanisms in tienilic acid associated hepatotoxicity

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7 January 2021

Anti-liver endoplasmic reticulum autoantibodies are directed against human cytochrome P-450IA2. A specific marker of dihydralazine-induced hepatitis.

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7 January 2021

The role of leukocyte-generated reactive metabolites in the pathogenesis of idiosyncratic drug reactions

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7 January 2021

An immunochemical approach of identifying and characterizing protein targets of toxic reactive metabolites

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7 January 2021

The organ toxicity of inhaled anesthetics

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7 January 2021

Hepatotoxicity after desflurane anesthesia.

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7 January 2021

Idiosyncratic liver toxicity of nonsteroidal antiinflammatory drugs: molecular mechanisms and pathology

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7 January 2021

Serum antibodies from halothane hepatitis patients react with the rat endoplasmic reticulum protein ERp72.

1 reference

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7 January 2021

The calcium-binding protein calreticulin is covalently modified in rat liver by a reactive metabolite of the inhalation anesthetic halothane

1 reference

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7 January 2021

A metabolite of halothane covalently binds to an endoplasmic reticulum protein that is highly homologous to phosphatidylinositol-specific phospholipase C-alpha but has no activity

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2897%2982327-6

7 January 2021

Halothane hepatitis patients have serum antibodies that react with protein disulfide isomerase

1 reference

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7 January 2021

10.1016/S0168-8278(97)82327-6

Identifiers

DOI

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1 reference