(Q41557034)

3 October 2017

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title

The role of beta-glucuronidase in drug disposition and drug targeting in humans (English)

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3 October 2017

Sperker B

1

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3 October 2017

Backman JT

series ordinal

2

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3 October 2017

Kroemer HK

series ordinal

3

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3 October 2017

1 July 1997

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Clinical Pharmacokinetics

3 October 2017

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3 October 2017

33

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3 October 2017

18-31

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3 October 2017

1

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https://scigraph.springernature.com/pub.10.2165/00003088-199733010-00003

3 October 2017

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cites work

Cloning, sequencing, and expression of cDNA for human beta-glucuronidase

1 reference

12 December 2020

Cloning and characterization of the human beta-glucuronidase gene

1 reference

12 December 2020

Interindividual variability in expression and activity of human beta-glucuronidase in liver and kidney: consequences for drug metabolism.

1 reference

12 December 2020

Localization of beta-glucuronidase in some human tumors

1 reference

12 December 2020

Mutational analysis of a patient with mucopolysaccharidosis type VII, and identification of pseudogenes

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12 December 2020

Long lasting respiratory depression induced by morphine-6-glucuronide?

1 reference

12 December 2020

Multiple-dose pharmacokinetics of imipramine and its major active and conjugated metabolites in depressed patients

1 reference

12 December 2020

Cure of Mice bearing Advanced Plasma Cell Tumours with Aniline Mustard : the Relationship between Glucuronidase Activity and Tumour Sensitivity

1 reference

12 December 2020

Molecular analysis of a patient with hydrops fetalis caused by beta-glucuronidase deficiency, and evidence for additional pseudogenes

1 reference

12 December 2020

Purification and properties of β-glucuronidase from human placenta

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12 December 2020

Clinical pharmacology of NSAIDs

1 reference

12 December 2020

Serum immunoreactive beta-glucuronidase determined by an enzyme-linked immunosorbent assay in patients with hepatic diseases

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12 December 2020

Mammalian beta-glucuronidase: genetics, molecular biology, and cell biology

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12 December 2020

Lysosomes, lysosomal enzymes, and cancer.

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12 December 2020

Disposition of lorazepam in human beings: enterohepatic recirculation and first-pass effect

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12 December 2020

Stimulation of 3-benzo[a]pyrenyl glucuronide hydrolysis by calcium activation of microsomal beta-glucuronidase

1 reference

12 December 2020

Interruption of the enterohepatic circulation of digitoxin by cholestyramine. I. Protection against lethal digitoxin intoxication

1 reference

12 December 2020

Beta glucuronidase and hyperbilirubinaemia in breast fed infants of diabetic mothers

1 reference

12 December 2020

Prodrugs of anthracyclines for chemotherapy via enzyme-monoclonal antibody conjugates

1 reference

12 December 2020

Synthesis and separation of 18 beta-glycyrrhetyl monoglucuronide from serum of a patient with glycyrrhizin-induced pseudo-aldosteronism

1 reference

12 December 2020

Glucuronidation of diflunisal by rat liver microsomes. Effect of microsomal beta-glucuronidase activity

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12 December 2020

Tumor-selective modification of cellular microenvironment in vivo: effect of glucose infusion on the pH in normal and malignant rat tissues.

1 reference

12 December 2020

A monoclonal antibody-beta-glucuronidase conjugate as activator of the prodrug epirubicin-glucuronide for specific treatment of cancer.

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12 December 2020

Lumenal location of the microsomal beta-glucuronidase-egasyn complex

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12 December 2020

High-performance liquid chromatographic quantification of 4-methylumbelliferyl-beta-D-glucuronide as a probe for human beta-glucuronidase activity in tissue homogenates

1 reference

12 December 2020

Clofibrate disposition in renal failure and acute and chronic liver disease

1 reference

12 December 2020

Egasyn, a protein complexed with microsomal beta-glucuronidase

1 reference

12 December 2020

Detection of early changes in androgen-induced mouse renal beta-glucuronidase messenger ribonucleic acid using cloned complementary deoxyribonucleic acid

1 reference

12 December 2020

A cytotoxic agent can be generated selectively at cancer sites

1 reference

12 December 2020

A pseudodeficiency allele (D152N) of the human beta-glucuronidase gene

1 reference

12 December 2020

The analgesic activity of morphine-6-glucuronide

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12 December 2020

Characterization of the Subunits and Sugar Moiety of Human Placental and Leukemicβ-Glucuronidase

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12 December 2020

Analgesic activity of morphine-6-glucuronide

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12 December 2020

Diisopropylfluorophosphate increases clofibric acid clearance: supporting evidence for a futile cycle.

1 reference

12 December 2020

Protective effects of kampo medicines and baicalin against intestinal toxicity of a new anticancer camptothecin derivative, irinotecan hydrochloride (CPT-11), in rats.

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12 December 2020

The preparation and properties of beta-glucuronidase. IV. Inhibition by sugar acids and their lactones

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12 December 2020

Biochemical properties of recombinant human beta-glucuronidase synthesized in baby hamster kidney cells

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12 December 2020

Human serum β-glucuronidase; its measurement and some of its properties

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12 December 2020

Prodrugs of anthracycline antibiotics suited for tumor-specific activation

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12 December 2020

Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue

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12 December 2020

A new high-glucuronidase mouse tumor curable by aniline mustard therapy

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12 December 2020

Androgen environment and beta-glucuronidase activity in the human kidney

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12 December 2020

Prolonged sedation due to accumulation of conjugated metabolites of midazolam

1 reference

12 December 2020

Antibody-directed enzyme prodrug therapy

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12 December 2020

Potential use of D-glucaric acid derivatives in cancer prevention

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12 December 2020

Inhibition of Human Synovial β-Glucuronidase by Steroidal Compounds

1 reference

12 December 2020

Antigenic release of paf-acether and beta-glucuronidase from alveolar macrophages of asthmatics

1 reference

12 December 2020

Tumor-selective prodrug activation by fusion protein-mediated catalysis

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12 December 2020

Therapeutic trial of aniline mustard in patients with advanced cancer. Comparison of therapeutic response with cytochemical assessment of tumor cell beta-glucuronidase activity

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12 December 2020

Specific activation of glucuronide prodrugs by antibody-targeted enzyme conjugates for cancer therapy

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12 December 2020

Glycyrrhizic acid inhibits virus growth and inactivates virus particles

1 reference

12 December 2020

Changes in translational yield regulate tissue-specific expression of beta-glucuronidase

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12 December 2020

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12 December 2020

Biliary Excretion of Drugs in Man

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12 December 2020

Genetic control of levels of murine kidney glucuronidase mRNA in response to androgen

1 reference

12 December 2020

The presence of high beta-glucuronidase activity in cancer tissue

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12 December 2020

pH studies in human malignant tumours

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12 December 2020

Inhibition of beta-glucuronidase by natural glucuronides of kampo medicines using glucuronide of SN-38 (7-ethyl-10-hydroxycamptothecin) as a substrate.

1 reference

12 December 2020

Tumor-targeted cell killing with 8-hydroxyquinolyl-glucuronide

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12 December 2020

Tricyclic antidepressant and metabolite levels in chronic renal failure

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12 December 2020

Reduced clofibric acid clearance in renal dysfunction is due to a futile cycle

1 reference

12 December 2020

Inhibition of mouse tumor metastasis with nojirimycin-related compounds

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12 December 2020

THE CYTOLOGIC DEMONSTRATION OF β-GLUCURONIDASE EMPLOYING NAPHTHOL AS-BI GLUCURONIDE AND HEXAZONIUM PARAROSANILIN; A PRELIMINARY REPORT

1 reference

12 December 2020

Hydrolysis of glycyrrhizin to 18 beta-glycyrrhetyl monoglucuronide by lysosomal beta-D-glucuronidase of animal livers

1 reference

12 December 2020

Metabolism of aniline mustard [N,N-di-(2-Chloroethyl)-aniline]

1 reference

12 December 2020

Influence of renal failure, rheumatoid arthritis and old age on the pharmacokinetics of diflunisal

1 reference

12 December 2020

Influence of renal function on the steady-state pharmacokinetics of the antiarrhythmic propafenone and its phase I and phase II metabolites

1 reference

12 December 2020

Inhibition of beta-glucuronidase in human urine by ascorbic acid

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12 December 2020

Noninvasive measurement of interstitial pH profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy

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12 December 2020

Glucuronidation of diflunisal in liver and kidney microsomes of rat and man.

1 reference

12 December 2020

The signal for retention of the egasyn-glucuronidase complex within the endoplasmic reticulum

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12 December 2020

Study on the corticoid-like action of glycyrrhizine and the mechanism of its action.

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12 December 2020

Studies on the reactivity of acyl glucuronides--V. Glucuronide-derived covalent binding of diflunisal to bladder tissue of rats and its modulation by urinary pH and beta-glucuronidase.

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12 December 2020

Isolation, characterization, and radioimmunoassay of murine egasyn, a protein stabilizing glucuronidase membrane binding

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12 December 2020

Molecular and functional characterisation of a fusion protein suited for tumour specific prodrug activation

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12 December 2020

C-terminal processing of human beta-glucuronidase. The propeptide is required for full expression of catalytic activity, intracellular retention, and proper phosphorylation.

1 reference

12 December 2020

β-Glucuronidase Catalyzed Hydrolysis of Benzo[ a ]pyrene-3-Glucuronide and Binding to DNA

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12 December 2020

Elevated serum beta-glucuronidase activity in acquired immunodeficiency syndrome

1 reference

12 December 2020

Beta glucuronidase deficiency: report of clinical, radiologic, and biochemical features of a new mucopolysaccharidosis

1 reference

12 December 2020

Liver Microsomal β-Glucuronidase and UDP-GIucuronyltransferase

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12 December 2020

Analysis of the 5' flanking region of the human beta-glucuronidase gene

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12 December 2020

Antibody-directed enzyme prodrug therapy (ADEPT) for treatment of major solid tumour disease

1 reference

12 December 2020

Inhibition of 7,12-dimethylbenzanthracene-induced rat mammary tumorigenesis by 2,5-di-O-acetyl-D-glucaro-1, 4:6,3-dilactone, an in vivo β-glucuronidase inhibitor

1 reference

12 December 2020

Glucuronidation of drugs. A re-evaluation of the pharmacological significance of the conjugates and modulating factors

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12 December 2020

Structure of human beta-glucuronidase reveals candidate lysosomal targeting and active-site motifs

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12 December 2020

Evidence that d-glucaro-1,4-lactone shortens the pharmacological action of drugs being disposed via the bile as glucuronides

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12 December 2020

Stimulation of hepatic microsomal beta-glucuronidase by calcium

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12 December 2020

Characterization of novel anthracycline prodrugs activated by human beta-glucuronidase for use in antibody-directed enzyme prodrug therapy

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12 December 2020

Propranolol glucuronide cumulation during long-term propranolol therapy: a proposed storage mechanism for propranolol

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12 December 2020

Antibody-enzyme conjugates for cancer therapy

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12 December 2020

Autosomal dominant keratoderma, ichthyosiform dermatosis and elevated serum beta-glucuronidase

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12 December 2020

The origins and relative distribution of polysaccharidases in rheumatoid and osteoarthritic fluids

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12 December 2020

Human biliary beta-glucuronidase: correlation of its activity with deconjugation of bilirubin in the bile

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12 December 2020

β-Glucuronidase Activity in Tumors Accumulation of Radioiodinated Phenolphthalein

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12 December 2020

Localization by fluorescence in situ hybridization of the human functional beta-glucuronidase gene (GUSB) to 7q11.21 --> q11.22 and two pseudogenes to 5p13 and 5q13.

1 reference

12 December 2020

Involvement of the esterase active site of egasyn in compartmentalization of β-glucuronidase within the endoplasmic reticulum

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12 December 2020

Effect of esterase inhibition on the disposition of zomepirac glucuronide and its covalent binding to plasma proteins in the guinea pig.

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12 December 2020

Interferon Induction by Glycyrrhizin and Glycyrrhetinic Acid in Mice

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12 December 2020

Molecular analysis of patients with beta-glucuronidase deficiency presenting as hydrops fetalis or as early mucopolysaccharidosis VII

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12 December 2020

Human immune response to monoclonal antibody-enzyme conjugates in ADEPT pilot clinical trial

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12 December 2020

Dual Localization of β-Glucuronidase in Endoplasmic Reticulum and in Lysosomes

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12 December 2020

Enhanced uptake of doxorubicin into bronchial carcinoma: beta-glucuronidase mediates release of doxorubicin from a glucuronide prodrug (HMR 1826) at the tumor site

1 reference

12 December 2020

Synthesis and antimetastatic activity of 6-trichloroacetamido and 6-guanidino analogues of siastatin B

1 reference

12 December 2020

Hepatic conjugation/deconjugation cycling pathways. Computer simulations examining the effect of Michaelis-Menten parameters, enzyme distribution patterns, and a diffusional barrier on metabolite disposition

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12 December 2020

Deconjugation of bilirubin-IX alpha glucuronides: a physiologic role of hepatic microsomal beta-glucuronidase

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12 December 2020

Effect of bile salts on rates of formation, accumulation, and export of mutagenic metabolites from benzo(a)pyrene produced by the perfused rat liver.

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12 December 2020

Drug glucuronidation in humans

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12 December 2020

Licorice-induced hypermineralocorticoidism

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12 December 2020

10.2165/00003088-199733010-00003

Identifiers

DOI

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Dimensions Publication ID

3 October 2017

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