(Q41570003)

3 October 2017

1 reference

title

Drug metabolism: from experiments to regulatory aspects (English)

1 reference

3 October 2017

Garattini S

1

1 reference

PubMed ID

9262948

3 October 2017

language of work or name

English

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publication date

1 August 1997

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3 October 2017

Drug Metabolism Reviews

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3 October 2017

29

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3 October 2017

3

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3 October 2017

853-886

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Matrix-assisted laser desorption ionization (MALDI) mass spectrometry: a novel analytical tool in molecular biology and biotechnology

3 October 2017

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Protein mass spectrometry: applications to analytical biotechnology

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Biomedical and biochemical applications of liquid chromatography-mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

From electrophoretically separated protein to identification: strategies for sequence and mass analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

The relevance of pharmacokinetics in the development of biotechnology products

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

In vitro approaches can predict human drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

The role of individual human cytochromes P450 in drug metabolism and clinical response

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Relationship between phenytoin and tolbutamide hydroxylations in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Stereoselective disposition of flecainide in relation to the sparteine/debrisoquine metaboliser phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Genetic polymorphism of S-mephenytoin hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Molecular mechanism of slow acetylation of drugs and carcinogens in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Pharmacogenetic phenotyping and genotyping. Present status and future potential.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Relevance of induction of human drug-metabolizing enzymes: pharmacological and toxicological implications

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Formation of active metabolites of psychotropic drugs. An updated review of their significance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Disposition of the psychotropic drugs buspirone, MJ-13805 and piribedil, and of their common active metabolite 1-(2-pyrimidinyl)-piperazine in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

The pharmacogenetics of the selective serotonin reuptake inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

The role of cytochrome P4502D6 in the metabolism of paroxetine by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Clinical pharmacokinetics of selective serotonin reuptake inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Effects of short- and long-term administration of fluoxetine on the monoamine content of rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Clinical pharmacokinetics: current requirements and future perspectives from a regulatory point of view

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

From fenfluramine racemate to d-fenfluramine. Specificity and potency of the effects on the serotoninergic system and food intake

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Anorectic effect of fenfluramine isomers and metabolites: relationship between brain levels and in vitro potencies on serotonergic mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Accumulation of fluoxetine and norfluoxetine in human brain during therapeutic administration

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Fluoxetine and trifluoperazine in human brain: a 19F-nuclear magnetic resonance spectroscopy study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Anatomic evidence for a neurotoxic effect of (+/-)-fenfluramine upon serotonergic projections in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Comparative studies on the anorectic activity of d-fenfluramine in mice, rats, and guinea pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Propafenone and 5-hydroxypropafenone concentrations in the right atrium of patients undergoing heart surgery

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Therapeutic drug monitoring of antiarrhythmic drugs. Rationale and current status

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Amiodarone and desethylamiodarone distribution in the atrium and adipose tissue of patients undergoing short- and long-term treatment with amiodarone

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Clinical pharmacokinetics of altretamine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Hexamethylmelamine--a new drug with activity in solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Hexamethylmelamine (altretamine) activity as a single agent in previously untreated advanced ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Studies of the mode of action of antitumour triazenes and triazines-V. The correlation of the in vitro cytotoxicity and in vivo antitumour activity of hexamethylmelamine analogues with their metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Effect of a hepatic activation system on the antiproliferative activity of hexamethylmelamine against human tumor cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Pharmacologically guided phase I clinical trials based upon preclinical drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Effect of human renal and hepatic disease on the pharmacokinetics of anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Pharmacokinetics and pharmacodynamics in the critically ill patient

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

The biochemistry of P-glycoprotein-mediated multidrug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Mediation of cimetidine secretion by P-glycoprotein and a novel H(+)-coupled mechanism in cultured renal epithelial monolayers of LLC-PK1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Mechanisms of multidrug resistance and implications for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Transport of celiprolol across human intestinal epithelial (Caco-2) cells: mediation of secretion by multiple transporters including P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Modulation of adriamycin accumulation and efflux by flavonoids in HCT-15 colon cells. Activation of P-glycoprotein as a putative mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Genistein modulates the decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumour cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

SDZ PSC 833, a non-immunosuppressive cyclosporine: its potency in overcoming P-glycoprotein-mediated multidrug resistance of murine leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Resistance modification by PSC-833, a novel non-immunosuppressive cyclosporin A

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Distribution and activity of doxorubicin combined with SDZ PSC 833 in mice with P388 and P388/DOX leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Multidrug resistant transgenic mice as a novel pharmacologic tool

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Expression of a human multidrug resistance cDNA (MDR1) in the bone marrow of transgenic mice: resistance to daunomycin-induced leukopenia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

The role of leukocyte-generated reactive metabolites in the pathogenesis of idiosyncratic drug reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Acute liver necrosis following overdose of paracetamol

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Liver damage and impaired glucose tolerance after paracetamol overdosage.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Mechanisms of acetaminophen toxicity: immunochemical detection of drug-protein adducts.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

A metabolite of acetaminophen covalently binds to the 56 kDa selenium binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

On the role of Ca2+ in the toxicity of alkylating and oxidizing quinone imines in isolated hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Update of hepatotoxicity due to classes of drugs in common clinical use: non-steroidal drugs, anti-inflammatory drugs, antibiotics, antihypertensives, and cardiac and psychotropic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Diclofenac-associated hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Fatal hepatitis associated with diclofenac

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Properties of acyl glucuronides: implications for studies of the pharmacokinetics and metabolism of acidic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Acyl glucuronides revisited: is the glucuronidation process a toxification as well as a detoxification mechanism?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

The molecular basis of halothane-induced hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Non-linearity of neoplastic conversion induced in rat liver by low exposures to diethylnitrosamine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Endometrial cancer in tamoxifen-treated breast cancer patients: findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Genotoxic potential of tamoxifen and analogues in female Fischer F344/n rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

DNA damage as assessed by 32P-postlabelling in three rat strains exposed to dietary tamoxifen: the relationship between cell proliferation and liver tumour formation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

DNA adduct formation by tamoxifen with rat and human liver microsomal activation systems

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Microsomal and peroxidase activation of 4-hydroxy-tamoxifen to form DNA adducts: comparison with DNA adducts formed in Sprague-Dawley rats treated with tamoxifen.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Tamoxifen: evidence by 32P-postlabeling and use of metabolic inhibitors for two distinct pathways leading to mouse hepatic DNA adduct formation and identification of 4-hydroxytamoxifen as a proximate metabolite.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

A mechanistic hypothesis for DNA adduct formation by tamoxifen following hepatic oxidative metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Anorectic activity of fluoxetine and norfluoxetine in mice, rats and guinea-pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Releasing activities of d-fenfluramine and fluoxetine on rat hippocampal synaptosomes preloaded with [3H]serotonin.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

d-Fenfluramine- and d-norfenfluramine-induced hypophagia: differential mechanisms and involvement of postsynaptic 5-HT receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Chlorophenylpiperazine: a central serotonin agonist causing powerful anorexia in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Antagonist properties of 1-(2-pyrimidinyl)piperazine at presynaptic alpha 2-adrenoceptors in the rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

Distinct induction profiles of three phenobarbital-responsive mouse liver cytochrome P450 isozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037598

10.3109/03602539709037598

21 January 2018

Identifiers

DOI

1 reference

3 October 2017

1 reference

PubMed ID

9262948