(Q41580184)

4 October 2017

DYRK1A in Down syndrome: an oncogene or tumor suppressor? (English)

1 reference

4 October 2017

1 reference

Yehudit Birger

1

1 reference

4 October 2017

Shai Izraeli

series ordinal

2

1 reference

4 October 2017

language of work or name

English

0 references

publication date

22 February 2012

1 reference

Journal of Clinical Investigation

4 October 2017

1 reference

4 October 2017

122

1 reference

4 October 2017

3

1 reference

4 October 2017

807-810

1 reference

Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome.

4 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287238

Large-scale analysis of chromosomal aberrations in cancer karyotypes reveals two distinct paths to aneuploidy

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287238

Infections and immunodeficiency in Down syndrome

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287238

NFAT, immunity and cancer: a transcription factor comes of age.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287238

Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndrome

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287238

miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287238

Function and regulation of Dyrk1A: towards understanding Down syndrome

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287238

Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287238

ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287238

Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287238

Trisomy 21 enhances human fetal erythro-megakaryocytic development

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287238

The role of the proto-oncogene ETS2 in acute megakaryocytic leukemia biology and therapy

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287238

Prediction of chromosomal aneuploidy from gene expression data.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287238

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287238

Overexpression of FKBP51 in idiopathic myelofibrosis regulates the growth factor independence of megakaryocyte progenitors

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287238

Pattern of malignant disorders in individuals with Down's syndrome.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287238

Decreased AIRE expression and global thymic hypofunction in Down syndrome.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287238

ERG is a megakaryocytic oncogene.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287238

Abnormalities in the myeloid progenitor compartment in Down syndrome fetal liver precede acquisition of GATA1 mutations

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287238

Trisomy 21 tilts the balance

19 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22354166

12 December 2020

inferred from PubMed ID database lookup

Calcineurin-NFAT signaling critically regulates early lineage specification in mouse embryonic stem cells and embryos

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22354166

12 December 2020

inferred from PubMed ID database lookup

Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22354166

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1172/JCI62372

1 reference

release_35f7vzv6gbcttdw5w62ly653ga

4 October 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/35f7vzv6gbcttdw5w62ly653ga

24 November 2022

mapped directly with Wikidata item

1 reference

4 October 2017

1 reference