(Q37580743)

21 August 2017

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title

Function and regulation of Dyrk1A: towards understanding Down syndrome (English)

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21 August 2017

Joongkyu Park

1

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21 August 2017

Woo-Joo Song

series ordinal

2

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21 August 2017

Kwang Chul Chung

series ordinal

3

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21 August 2017

language of work or name

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14 August 2009

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Cellular and Molecular Life Sciences

21 August 2017

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21 August 2017

66

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21 August 2017

3235-3240

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21 August 2017

20

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https://scigraph.springernature.com/pub.10.1007/s00018-009-0123-2

21 August 2017

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cites work

Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice.

1 reference

12 December 2020

Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation.

1 reference

12 December 2020

Tau in Alzheimer's disease and Down's syndrome is insoluble and abnormally phosphorylated

1 reference

12 December 2020

Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome.

1 reference

12 December 2020

A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT

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12 December 2020

Aggressive behaviour associated with donepezil treatment: a case report

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12 December 2020

Molecular genetic approach to the characterization of the "Down syndrome region" of chromosome 21.

1 reference

12 December 2020

Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A.

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12 December 2020

Critical role of the D21S55 region on chromosome 21 in the pathogenesis of Down syndrome

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12 December 2020

The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development

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12 December 2020

Altered long-term potentiation in the young and old Ts65Dn mouse, a model for Down Syndrome.

1 reference

12 December 2020

Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome.

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12 December 2020

The spatio-temporal and subcellular expression of the candidate Down syndrome gene Mnb/Dyrk1A in the developing mouse brain suggests distinct sequential roles in neuronal development.

1 reference

12 December 2020

The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome

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12 December 2020

Study of somatic chromosomes from 9 mongoloid children

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12 December 2020

QSAR analysis of pyrazolidine-3,5-diones derivatives as Dyrk1A inhibitors

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12 December 2020

A mouse model for Down syndrome exhibits learning and behaviour deficits.

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12 December 2020

Structural and functional characteristics of Dyrk, a novel subfamily of protein kinases with dual specificity.

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12 December 2020

Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test.

1 reference

12 December 2020

Presenile dementia and Alzheimer's disease in mongolism.

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12 December 2020

Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome.

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12 December 2020

Amyloid plaque core protein in Alzheimer disease and Down syndrome

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12 December 2020

Regulation of Dyrk1A kinase activity by 14-3-3.

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12 December 2020

The causes of Down syndrome

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12 December 2020

Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome "critical region"

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12 December 2020

Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKs

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12 December 2020

Regulation of the proapoptotic activity of huntingtin interacting protein 1 by Dyrk1 and caspase-3 in hippocampal neuroprogenitor cells

1 reference

12 December 2020

Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome

1 reference

12 December 2020

The MNB/DYRK1A protein kinase: neurobiological functions and Down syndrome implications

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12 December 2020

The neuropsychology of mental retardation

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12 December 2020

Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome

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12 December 2020

DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease

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12 December 2020

Truncation of the Down syndrome candidate gene DYRK1A in two unrelated patients with microcephaly

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12 December 2020

Piracetam therapy does not enhance cognitive functioning in children with down syndrome

1 reference

12 December 2020

The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease

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12 December 2020

Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer's disease

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12 December 2020

A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells

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12 December 2020

Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome.

1 reference

12 December 2020

Molecular definition of a region of chromosome 21 that causes features of the Down syndrome phenotype

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12 December 2020

Abnormal synaptic plasticity in the Ts1Cje segmental trisomy 16 mouse model of Down syndrome

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12 December 2020

minibrain: a new protein kinase family involved in postembryonic neurogenesis in Drosophila.

1 reference

12 December 2020

The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome

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12 December 2020

The MNB/DYRK1A protein kinase: genetic and biochemical properties

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12 December 2020

The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome

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12 December 2020

Down syndrome phenotypes: the consequences of chromosomal imbalance

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12 December 2020

Dyrk1A overexpression in immortalized hippocampal cells produces the neuropathological features of Down syndrome

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12 December 2020

Alterations in the phenotype of neocortical pyramidal cells in the Dyrk1A+/- mouse

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12 December 2020

Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1

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12 December 2020

Attenuation of Notch signalling by the Down-syndrome-associated kinase DYRK1A.

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12 December 2020

Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships

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12 December 2020

Down syndrome and Alzheimer disease: response to donepezil

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12 December 2020

Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome.

1 reference

12 December 2020

Phosphorylation of Ser640 in Muscle Glycogen Synthase by DYRK Family Protein Kinases

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12 December 2020

Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII

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12 December 2020

The Down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4.

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12 December 2020

Characterization of the human DYRK1A promoter and its regulation by the transcription factor E2F1.

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12 December 2020

Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice

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12 December 2020

A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region

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12 December 2020

Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome

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12 December 2020

DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects.

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12 December 2020

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.

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12 December 2020

DYRK1A accumulates in splicing speckles through a novel targeting signal and induces speckle disassembly

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12 December 2020

The selectivity of protein kinase inhibitors: a further update

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12 December 2020

Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models

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12 December 2020

Down syndrome and the genes of human chromosome 21: current knowledge and future potentials

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12 December 2020

Putative therapeutic agents for the learning and memory deficits of people with Down syndrome.

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12 December 2020

DYRK1A is a novel negative regulator of cardiomyocyte hypertrophy

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12 December 2020

The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome

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12 December 2020

Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities

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12 December 2020

10.1007/S00018-009-0123-2

Identifiers

DOI

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21 August 2017

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