(Q48426203)

11 February 2018

title

Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation. (English)

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11 February 2018

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Eun Joo Kim

1

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11 February 2018

Jee Young Sung

2

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11 February 2018

Hyun Jung Lee

3

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11 February 2018

Hyewhon Rhim

4

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11 February 2018

Masato Hasegawa

5

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11 February 2018

Takeshi Iwatsubo

6

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11 February 2018

Do Sik Min

7

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11 February 2018

Jongsun Kim

8

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11 February 2018

Seung R Paik

9

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11 February 2018

Kwang Chul Chung

10

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11 February 2018

language of work or name

English

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publication date

7 September 2006

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11 February 2018

Journal of Biological Chemistry

published in

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11 February 2018

volume

281

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11 February 2018

page(s)

33250-33257

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11 February 2018

issue

44

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11 February 2018

The Role of alpha-synuclein assembly and metabolism in the pathogenesis of Lewy body disease

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Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII

21 January 2018

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A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region

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Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome.

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Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

21 January 2018

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Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.

21 January 2018

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Synucleins are a novel class of substrates for G protein-coupled receptor kinases

21 January 2018

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Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125.

21 January 2018

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Antibodies to alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease.

21 January 2018

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Dementia with Lewy bodies in Down's syndrome

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Parkin cleaves intracellular alpha-synuclein inclusions via the activation of calpain

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Protein kinase Dyrk1 activates cAMP response element-binding protein during neuronal differentiation in hippocampal progenitor cells.

21 January 2018

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Bruton's tyrosine kinase phosphorylates cAMP-responsive element-binding protein at serine 133 during neuronal differentiation in immortalized hippocampal progenitor cells

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Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases

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Dyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4

21 January 2018

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Induction of neuronal cell death by Rab5A-dependent endocytosis of alpha-synuclein

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Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein

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Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation.

21 January 2018

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Metal-catalyzed oxidation of alpha-synuclein in the presence of Copper(II) and hydrogen peroxide.

21 January 2018

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alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases

21 January 2018

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Activation of Pyk2/RAFTK induces tyrosine phosphorylation of alpha-synuclein via Src-family kinases

21 January 2018

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Regulation of the proapoptotic activity of huntingtin interacting protein 1 by Dyrk1 and caspase-3 in hippocampal neuroprogenitor cells

21 January 2018

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Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models

21 January 2018

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Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

21 January 2018

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Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

21 January 2018

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Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M606147200

1 reference

11 February 2018

PubMed ID

16959772

1 reference

11 February 2018