(Q41582903)

4 October 2017

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title

Rational design of stable lyophilized protein formulations: some practical advice (English)

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4 October 2017

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Carpenter JF

1

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4 October 2017

Pikal MJ

series ordinal

2

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4 October 2017

Chang BS

series ordinal

3

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4 October 2017

Randolph TW

series ordinal

4

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4 October 2017

publication date

1 August 1997

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4 October 2017

published in

Pharmaceutical Research

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4 October 2017

volume

14

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4 October 2017

issue

8

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4 October 2017

page(s)

969-975

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The physico-chemical basis for the freeze-drying process

4 October 2017

cites work

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12 December 2020

Separation of freezing- and drying-induced denaturation of lyophilized proteins using stress-specific stabilization. II. Structural studies using infrared spectroscopy.

1 reference

12 December 2020

Surface-induced denaturation of proteins during freezing and its inhibition by surfactants

1 reference

12 December 2020

Polymers protect lactate dehydrogenase during freeze-drying by inhibiting dissociation in the frozen state

1 reference

12 December 2020

Characterization of a solid state reaction product from a lyophilized formulation of a cyclic heptapeptide. A novel example of an excipient-induced oxidation

1 reference

12 December 2020

Counteracting effects of thiocyanate and sucrose on chymotrypsinogen secondary structure and aggregation during freezing, drying, and rehydration

1 reference

12 December 2020

Stability of protein formulations: investigation of surfactant effects by a novel EPR spectroscopic technique

1 reference

12 December 2020

Measurement of glass transition temperatures of freeze-concentrated solutes by differential scanning calorimetry

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12 December 2020

Strategies to suppress aggregation of recombinant keratinocyte growth factor during liquid formulation development

1 reference

12 December 2020

Physical factors affecting the storage stability of freeze-dried interleukin-1 receptor antagonist: glass transition and protein conformation

1 reference

12 December 2020

Separation of freezing- and drying-induced denaturation of lyophilized proteins using stress-specific stabilization. I. Enzyme activity and calorimetric studies

1 reference

12 December 2020

Decreased protein-stabilizing effects of cryoprotectants due to crystallization

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12 December 2020

Proteins in frozen solutions: evidence of ice-induced partial unfolding

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12 December 2020

The effects of formulation variables on the stability of freeze-dried human growth hormone

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12 December 2020

Dehydration-induced conformational transitions in proteins and their inhibition by stabilizers

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12 December 2020

Infrared Spectroscopic Studies of Lyophilization‐ and Temperature‐Induced Protein Aggregation

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12 December 2020

Is trehalose special for preserving dry biomaterials?

1 reference

12 December 2020

Optimization of lyophilization conditions for recombinant human interleukin-2 by dried-state conformational analysis using Fourier-transform infrared spectroscopy

1 reference

12 December 2020

Effect of freezing on the pH and composition of sodium and potassium phosphate solutions; the reciprocal system KH2PO4-Na2-HPO4-H2O

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12 December 2020

Stability of protein pharmaceuticals

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12 December 2020

Identifiers

DOI

10.1023/A:1012180707283

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4 October 2017

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