(Q41585210)

4 October 2017

title

A model to describe how a point mutation of the estrogen receptor alters the structure-function relationship of antiestrogens (English)

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4 October 2017

3

V C Jordan

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4 October 2017

S Y Jiang

1

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4 October 2017

C J Parker

series ordinal

2

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4 October 2017

language of work or name

English

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publication date

1 January 1993

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Breast Cancer Research and Treatment

4 October 2017

published in

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4 October 2017

volume

26

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4 October 2017

issue

2

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4 October 2017

page(s)

139-147

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https://scigraph.springernature.com/pub.10.1007/bf00689687

4 October 2017

exact match

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cites work

Structure-activity relationships of nonisomerizable derivatives of tamoxifen: importance of hydroxyl group and side chain positioning for biological activity

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12 December 2020

Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen

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12 December 2020

The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor

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12 December 2020

Effects of adjuvant tamoxifen and of cytotoxic therapy on mortality in early breast cancer. An overview of 61 randomized trials among 28,896 women.

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12 December 2020

Laboratory studies to develop general principles for the adjuvant treatment of breast cancer with antiestrogens: problems and potential for future clinical applications

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12 December 2020

Regulation of prolactin synthesis in vitro by estrogenic and antiestrogenic derivatives of estradiol and estrone

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12 December 2020

Point mutation of estrogen receptor (ER) in the ligand-binding domain changes the pharmacology of antiestrogens in ER-negative breast cancer cells stably expressing complementary DNAs for ER.

1 reference

12 December 2020

A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity

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12 December 2020

Growth regulation of estrogen receptor-negative breast cancer cells transfected with complementary DNAs for estrogen receptor

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12 December 2020

Human breast cancer in the athymic nude mouse: cytostatic effects of long-term antiestrogen therapy

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12 December 2020

Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers

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12 December 2020

Contrasting actions of tamoxifen on endometrial and breast tumor growth in the athymic mouse

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12 December 2020

An estrogen receptor model to describe the regulation of prolactin synthesis by antiestrogens in vitro

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12 December 2020

The human estrogen receptor has transcriptional activator and repressor functions in the absence of ligand

1 reference

12 December 2020

Ligand interaction at the estrogen receptor to program antiestrogen action: a study with nonsteroidal compounds in vitro

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12 December 2020

Structure-function relationships of hydroxylated metabolites of tamoxifen that control the proliferation of estrogen-responsive T47D breast cancer cells in vitro.

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12 December 2020

Steroid receptor family: structure and functions

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12 December 2020

Antagonism of estrogen action with a new benzothiophene derived antiestrogen

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12 December 2020

Mutagenesis of cysteines in the hormone binding domain of the human estrogen receptor. Alterations in binding and transcriptional activation by covalently and reversibly attaching ligands

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12 December 2020

Biochemical pharmacology of antiestrogen action

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12 December 2020

A new derivative of triphenylethylene: effect on implantation and mode of action in rats.

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12 December 2020

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

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12 December 2020

The pharmacology and clinical uses of tamoxifen

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12 December 2020

Development of tamoxifen-stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration

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12 December 2020

Aberrant response in vitro of hormone-responsive prostate cancer cells to antiandrogens

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12 December 2020

The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties

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12 December 2020

Stimulatory effects of antiandrogens on LNCaP human prostate tumor cell growth, EGF-receptor level and acid phosphatase secretion

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12 December 2020

Sequence and expression of human estrogen receptor complementary DNA

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12 December 2020

Adjuvant tamoxifen in early breast cancer: occurrence of new primary cancers

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12 December 2020

A simple, rapid, and sensitive DNA assay procedure

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12 December 2020

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer

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12 December 2020

A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF00689687

1 reference

Dimensions Publication ID

4 October 2017

1038921202

0 references

1 reference