(Q41661649)

6 October 2017

CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington's disease (English)

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6 October 2017

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8

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6 October 2017

Su Yang

1

1 reference

6 October 2017

Renbao Chang

2

1 reference

6 October 2017

Huiming Yang

3

1 reference

6 October 2017

Ting Zhao

4

1 reference

6 October 2017

Yan Hong

5

1 reference

6 October 2017

Ha Eun Kong

6

1 reference

6 October 2017

Xiaobo Sun

7

1 reference

6 October 2017

Peng Jin

9

1 reference

6 October 2017

Shihua Li

10

1 reference

6 October 2017

Xiao-Jiang Li

11

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6 October 2017

language of work or name

English

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publication date

19 June 2017

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Journal of Clinical Investigation

6 October 2017

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6 October 2017

127

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6 October 2017

2719-2724

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6 October 2017

7

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CRISPR/Cas9 Editing of the Mutant Huntingtin Allele In Vitro and In Vivo

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490741

N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490741

Ablation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490741

In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490741

Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490741

Allele-specific silencing of mutant huntingtin in rodent brain and human stem cells

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490741

Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the Huntington disease gene / allele-specific silencing of mutant huntingtin

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490741

Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490741

Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490741

Allele-specific RNA interference for neurological disease

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490741

RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490741

Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490741

Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490741

Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490741

Neurological abnormalities in a knock-in mouse model of Huntington's disease

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490741

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490741

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490741

In vivo imaging of brain glutamate defects in a knock-in mouse model of Huntington's disease.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490741

Off-target mutations are rare in Cas9-modified mice.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490741

Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490741

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490741

18 August 2018

Identifiers

DOI

10.1172/JCI92087

1 reference

release_hrcbz6flnvhbroh3p6de643vxu

6 October 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/hrcbz6flnvhbroh3p6de643vxu

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

6 October 2017

1 reference