(Q33849553)

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Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing.

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21 March 2020

Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24996167%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

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whole genome sequencing

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based on heuristic

inferred from title

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21 March 2020

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21 March 2020

Michael E. Talkowski

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21 March 2020

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Adrian Veres

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21 March 2020

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Chad A Cowan

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21 March 2020

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Bridget S Gosis

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21 March 2020

Qiurong Ding

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21 March 2020

Ashok Ragavendran

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21 March 2020

Harrison Brand

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21 March 2020

Kiran Musunuru

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21 March 2020

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publication date

1 July 2014

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21 March 2020

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21 March 2020

15

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21 March 2020

1

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21 March 2020

27-30

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21 March 2020

Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082799

5 July 2018

CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082799

5 July 2018

High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082799

5 July 2018

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082799

5 July 2018

DNA targeting specificity of RNA-guided Cas9 nucleases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082799

5 July 2018

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082799

5 July 2018

Genome editing of human pluripotent stem cells to generate human cellular disease models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082799

5 July 2018

Enhanced efficiency of human pluripotent stem cell genome editing through replacing TALENs with CRISPRs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082799

5 July 2018

RNA-programmed genome editing in human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082799

5 July 2018

Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082799

5 July 2018

RNA-guided human genome engineering via Cas9

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082799

5 July 2018

Multiplex genome engineering using CRISPR/Cas systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082799

5 July 2018

A TALEN genome-editing system for generating human stem cell-based disease models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082799

5 July 2018

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082799

5 July 2018

Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082799

5 July 2018

A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082799

5 July 2018

Genetic engineering of human pluripotent cells using TALE nucleases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082799

5 July 2018

Genetic correction and analysis of induced pluripotent stem cells from a patient with gyrate atrophy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082799

5 July 2018

Somatic coding mutations in human induced pluripotent stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082799

5 July 2018

Copy number variation and selection during reprogramming to pluripotency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082799

5 July 2018

A TALE nuclease architecture for efficient genome editing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082799

5 July 2018

Identifiers

10.1016/J.STEM.2014.04.020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24996167%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

PMC publication ID

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Europe PubMed Central

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21 March 2020

PubMed publication ID

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Europe PubMed Central

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21 March 2020

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