(Q41672853)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9416417%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

review article

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title

Chemical engineering of RNase resistant and catalytically active hammerhead ribozymes (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9416417%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

0 references

0 references

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9416417%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

author name string

A Favre

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9416417%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

J L Fourrey

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9416417%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

language of work or name

English

0 references

publication date

1 November 1997

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9416417%20AND%20SRC:MED&resulttype=core&format=json

Bioorganic & Medicinal Chemistry

8 November 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9416417%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

volume

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9416417%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

issue

11

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9416417%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

page(s)

1999-2010

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9416417%20AND%20SRC:MED&resulttype=core&format=json

Progress in antisense oligonucleotide therapeutics

8 November 2019

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A catalytic 13-mer ribozyme

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Chemical synthesis of biologically active oligoribonucleotides using beta-cyanoethyl protected ribonucleoside phosphoramidites

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Ribozymes as human therapeutic agents

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Current concepts in antisense drug design

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7 January 2021

Hammerhead ribozyme engineering

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7 January 2021

Numbering system for the hammerhead

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7 January 2021

Sequence requirements of the hammerhead RNA self-cleavage reaction

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7 January 2021

The hammerhead RNA domain, a model ribozyme

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7 January 2021

Comparative analysis of cleavage rates after systematic permutation of the NUX consensus target motif for hammerhead ribozymes

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7 January 2021

A kinetic and thermodynamic analysis of cleavage site mutations in the hammerhead ribozyme

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7 January 2021

Extended target-site specificity for a hammerhead ribozyme

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7 January 2021

Kinetics of intermolecular cleavage by hammerhead ribozymes

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7 January 2021

A kinetic and thermodynamic framework for the hammerhead ribozyme reaction

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7 January 2021

The internal equilibrium of the hammerhead ribozyme reaction

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7 January 2021

Fluorescence resonance energy transfer analysis of ribozyme kinetics reveals the mode of action of a facilitator oligonucleotide

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7 January 2021

Unexpected anisotropy in substrate cleavage rates by asymmetric hammerhead ribozymes.

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7 January 2021

Extension of helix II of an HIV-1-directed hammerhead ribozyme with long antisense flanks does not alter kinetic parametersin vitrobut causes loss of the inhibitory potential in living cells

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7 January 2021

The influence of imperfectly paired helices I and III on the catalytic activity of hammerhead ribozymes

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7 January 2021

The effect of base mismatches in the substrate recognition helices of hammerhead ribozymes on binding and catalysis

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7 January 2021

Protein enhancement of hammerhead ribozyme catalysis

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7 January 2021

Ribozyme-mediated RNA degradation in nuclei suspension

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7 January 2021

Enhancement of ribozyme catalytic activity by a contiguous oligodeoxynucleotide (facilitator) and by 2'-O-methylation

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7 January 2021

Oligonucleotide facilitators may inhibit or activate a hammerhead ribozyme

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7 January 2021

Efficient Improvement of Hammerhead Ribozyme Mediated Cleavage of Long Substrates by Oligonucleotide Facilitators†

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7 January 2021

Three-dimensional structure of a hammerhead ribozyme

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7 January 2021

The crystal structure of an all-RNA hammerhead ribozyme: a proposed mechanism for RNA catalytic cleavage

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7 January 2021

Global conformation of a self-cleaving hammerhead RNA

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7 January 2021

The global conformation of an active hammerhead RNA during the process of self-cleavage

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7 January 2021

Ionic interactions and the global conformations of the hammerhead ribozyme

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7 January 2021

A three-dimensional model for the hammerhead ribozyme based on fluorescence measurements

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7 January 2021

Multiple folded conformations of a hammerhead ribozyme domain under cleavage conditions

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7 January 2021

Thiophosphate interference experiments locate phosphates important for the hammerhead RNA self-cleavage reaction

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7 January 2021

Capturing the structure of a catalytic RNA intermediate: the hammerhead ribozyme

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7 January 2021

Ribozymes: a distinct class of metalloenzymes

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7 January 2021

Role of divalent metal ions in the hammerhead RNA cleavage reaction

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7 January 2021

Relationship between 2'-hydroxyls and magnesium binding in the hammerhead RNA domain: a model for ribozyme catalysis

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7 January 2021

Mg(2+)-dependent conformational changes in the hammerhead ribozyme

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7 January 2021

Evidence for the role of solvated metal hydroxide in the hammerhead cleavage mechanism

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7 January 2021

Two autolytic processing reactions of a satellite RNA proceed with inversion of configuration

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7 January 2021

Configurationally defined phosphorothioate-containing oligoribonucleotides in the study of the mechanism of cleavage of hammerhead ribozymes

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7 January 2021

Cleavage properties of an oligonucleotide containing a bridged internucleotide 5'-phosphorothioate RNA linkage

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7 January 2021

Chemical modification of hammerhead ribozymes. Catalytic activity and nuclease resistance

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7 January 2021

Optimizing the cell efficacy of synthetic ribozymes. Site selection and chemical modifications of ribozymes targeting the proto-oncogene c-myb.

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7 January 2021

Catalytic activity and stability of hammerhead ribozymes containing 2'-acetamido-2'-deoxyribonucleosides.

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7 January 2021

In vivo decay kinetic parameters of hammerhead ribozymes

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7 January 2021

Mixed deoxyribo- and ribo-oligonucleotides with catalytic activity

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7 January 2021

Mixed DNA/RNA polymers are cleaved by the hammerhead ribozyme

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7 January 2021

Minimum ribonucleotide requirement for catalysis by the RNA hammerhead domain

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7 January 2021

Nuclease-resistant chimeric ribozymes containing deoxyribonucleotides and phosphorothioate linkages

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7 January 2021

Effects of deoxyribonucleotide substitutions in the substrate strand on hammerhead ribozyme-catalyzed reactions

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7 January 2021

A ribozyme with DNA in the hybridising arms displays enhanced cleavage ability

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7 January 2021

Chimeric DNA-RNA hammerhead ribozymes have enhanced in vitro catalytic efficiency and increased stability in vivo

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7 January 2021

Enhancement of the cleavage rates of DNA-armed hammerhead ribozymes by various divalent metal ions

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7 January 2021

A comparison of the in vitro activity of DNA-armed and all-RNA hammerhead ribozymes

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7 January 2021

Extraordinary enhancement of the cleavage activity of a DNA-armed hammerhead ribozyme at elevated concentrations of Mg2+ ions

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7 January 2021

Nuclease resistant ribozymes with high catalytic activity

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7 January 2021

In vitro activity of minimised hammerhead ribozymes

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7 January 2021

Using linkers to investigate the spatial separation of the conserved nucleotides A9 and G12 in the hammerhead ribozyme

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7 January 2021

Morpholino-Linked Ribozymes: A Convergent Synthetic Approach

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7 January 2021

Importance of exocyclic base functional groups of central core guanosines for hammerhead ribozyme activity

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7 January 2021

Activity of the Hammerhead Ribozyme upon Inversion of the Stereocenters for the Guanosine 2'-Hydroxyls

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7 January 2021

The role of the exocyclic amino groups of conserved purines in hammerhead ribozyme cleavage

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7 January 2021

Study of a hammerhead ribozyme containing 2'-modified adenosine residues

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7 January 2021

Isoguanosine substitution of conserved adenosines in the hammerhead ribozyme

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7 January 2021

Importance of specific adenosine N3-nitrogens for efficient cleavage by a hammerhead ribozyme

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7 January 2021

The synthesis of oligoribonucleotides containing O6-methylguanosine: the role of conserved guanosine residues in hammerhead ribozyme cleavage

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7 January 2021

Importance of specific guanosine N7-nitrogens and purine amino groups for efficient cleavage by a hammerhead ribozyme

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7 January 2021

Chemically modified hammerhead ribozymes with improved catalytic rates

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7 January 2021

Importance of specific adenosine N7-nitrogens for efficient cleavage by a hammerhead ribozyme. A model for magnesium binding

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7 January 2021

The roles of the conserved pyrimidine bases in hammerhead ribozyme catalysis: evidence for a magnesium ion-binding site

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7 January 2021

A synthetic, chemically modified ribozyme eliminates amelogenin, the major translation product in developing mouse enamel in vivo.

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7 January 2021

Ribozyme mediated destruction of RNA in vivo

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7 January 2021

Ribozymes as potential anti-HIV-1 therapeutic agents.

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7 January 2021

Ribozyme-mediated inhibition of expression of leukocyte-type 12-lipoxygenase in porcine aortic vascular smooth muscle cells

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7 January 2021

Correlation of activity with stability of chemically modified ribozymes in nuclei suspension

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7 January 2021

10.1016/S0968-0896(97)00144-2

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9416417%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

1 reference