(Q41687861)

7 October 2017

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title

Monoclonal antibodies to growth factors and growth factor receptors: their diagnostic and therapeutic potential in brain tumors (English)

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7 October 2017

3

Bigner DD

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7 October 2017

Ashley DM

1

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PubMed ID

9440024

7 October 2017

Batra SK

series ordinal

2

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7 October 2017

1 December 1997

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Journal of Neuro-Oncology

7 October 2017

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7 October 2017

35

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7 October 2017

259-273

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7 October 2017

3

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https://scigraph.springernature.com/pub.10.1023/a:1005812417638

7 October 2017

0 references

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12 December 2020

Transforming growth factor-alpha-Pseudomonas exotoxin fusion protein (TGF-alpha-PE38) treatment of subcutaneous and intracranial human glioma and medulloblastoma xenografts in athymic mice.

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12 December 2020

Deletion-mutant epidermal growth factor receptor in human gliomas: Effect of type II mutation on receptor function

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Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells

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Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms

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12 December 2020

Improving the tumor retention of radioiodinated antibody: aryl carbohydrate adducts

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12 December 2020

Tumor antigens in astrocytic gliomas

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12 December 2020

Anti-epidermal growth factor receptor monoclonal antibodies may inhibit A431 tumor cell proliferation by blocking an autocrine pathway

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12 December 2020

The epidermal growth factor receptor as a target for therapy in breast carcinoma

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12 December 2020

Convection-enhanced delivery of macromolecules in the brain

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12 December 2020

Acidic and Basic Fibroblast Growth Factors Are Present in Glioblastoma Multiforme and Normal Brain

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12 December 2020

Comparisons between two monoclonal antibodies that bind to the same antigen but have differing affinities: uptake kinetics and 125I-antibody therapy efficacy in multicell spheroids

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12 December 2020

Specific imaging of human brain tumor xenografts utilizing radiolabelled monoclonal antibodies (MAbs).

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12 December 2020

Mouse/human chimeric Me1-14 antibody: genomic cloning of the variable region genes, linkage to human constant region genes, expression, and characterization

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12 December 2020

A deletion mutation within the ligand binding domain is responsible for activation of epidermal growth factor receptor gene in human brain tumors

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12 December 2020

Antibody guided diagnosis and therapy of brain gliomas using radiolabeled monoclonal antibodies against epidermal growth factor receptor and placental alkaline phosphatase.

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12 December 2020

Epidermal growth factor receptor-reactive monoclonal antibodies: xenograft antitumor activity alone and as drug immunoconjugates.

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12 December 2020

Effect of epidermal growth factor on glioma cell growth, migration, and invasion in vitro.

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12 December 2020

Comparative localization of murine monoclonal antibody Me1-14 F(ab')2 fragment and whole IgG2a in human glioma xenografts

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12 December 2020

Intrathecal 131I-labeled antitenascin monoclonal antibody 81C6 treatment of patients with leptomeningeal neoplasms or primary brain tumor resection cavities with subarachnoid communication: phase I trial results

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12 December 2020

Immunoreactivity, pharmacokinetics and bone marrow dosimetry of intrathecal radioimmunoconjugates

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12 December 2020

Intrathecal administration of 131I radiolabelled monoclonal antibody as a treatment for neoplastic meningitis

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12 December 2020

Expression of c-sis and platelet-derived growth factor in in vitro-transformed glioma cells from rat brain tissue transplacentally treated with ethylnitrosourea

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12 December 2020

Immunotoxins that target an oncogenic mutant epidermal growth factor receptor expressed in human tumors.

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12 December 2020

Growth inhibition of human breast cancer cells in vitro with an antibody against the type I somatomedin receptor

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12 December 2020

Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts.

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12 December 2020

Association between high levels of expression of the TRK gene and favorable outcome in human neuroblastoma

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12 December 2020

Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance

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12 December 2020

Interactions between growth factor receptors and corresponding monoclonal antibodies in human tumors

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12 December 2020

Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice

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12 December 2020

Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies

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12 December 2020

Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas.

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12 December 2020

Basic fibroblast growth factor-like activity and receptors are expressed in a human glioma cell line

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12 December 2020

Iodine125 labeled anti-epidermal growth factor receptor-425 in the treatment of malignant astrocytomas. A pilot study

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12 December 2020

Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts

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12 December 2020

Antiproliferative effect of trapidil, a platelet-derived growth factor antagonist, on a glioma cell line in vitro

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12 December 2020

A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity

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12 December 2020

Local treatment of malignant gliomas by direct infusion of specific monoclonal antibodies labeled with 131I: comparison of the results obtained in recurrent and newly diagnosed tumors.

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12 December 2020

Amplification and overexpression of the EGF receptor gene in primary human glioblastomas.

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12 December 2020

Immunotherapy of human glioma xenografts with unlabeled, 131I-, or 125I-labeled monoclonal antibody 425 to epidermal growth factor receptor

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12 December 2020

Receptor blockade with monoclonal antibodies as anti-cancer therapy

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12 December 2020

Prognostic relevance of epidermal growth factor receptor (EGF-R) and c-neu/erbB2 expression in glioblastomas (GBMs).

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12 December 2020

Phase I trial of 2B1, a bispecific monoclonal antibody targeting c-erbB-2 and Fc gamma RIII.

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12 December 2020

The role of growth factor receptors in central nervous system development and neoplasia

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12 December 2020

Acidic and basic fibroblast growth factors are present in glioblastoma multiforme

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12 December 2020

Intrathecal administration of single-chain immunotoxin, LMB-7 [B3(Fv)-PE38], produces cures of carcinomatous meningitis in a rat model

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12 December 2020

Epidermal growth factor receptor in human glioma.

1 reference

12 December 2020

Cytogenetics and molecular genetics: their status and role in understanding the behavior of central nervous system neoplasms

1 reference

12 December 2020

A human tumor xenograft model of therapy with a bispecific monoclonal antibody targeting c-erbB-2 and CD16

1 reference

12 December 2020

Pharmacokinetics and tumor localization of 131I-labeled anti-tenascin monoclonal antibody 81C6 in patients with gliomas and other intracranial malignancies.

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12 December 2020

Anti-epidermal growth factor receptor monoclonal antibodies as potential anti-cancer agents

1 reference

12 December 2020

Epidermal growth factor receptor as a target for therapy with antireceptor monoclonal antibodies

1 reference

12 December 2020

Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors

1 reference

12 December 2020

Neu differentiation factor: a transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit

1 reference

12 December 2020

Expression of two types of receptor for insulin-like growth factors in human malignant glioma.

1 reference

12 December 2020

Fibroblast growth factor receptor gene expression and immunoreactivity are elevated in human glioblastoma multiforme.

1 reference

12 December 2020

Phase I studies of treatment of malignant gliomas and neoplastic meningitis with 131I-radiolabeled monoclonal antibodies anti-tenascin 81C6 and anti-chondroitin proteoglycan sulfate Me1-14 F (ab')2--a preliminary report

1 reference

12 December 2020

Blockade of epidermal growth factor receptor function by bivalent and monovalent fragments of 225 anti-epidermal growth factor receptor monoclonal antibodies.

1 reference

12 December 2020

Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma

1 reference

12 December 2020

Monoclonal antibody and F(ab')2 fragment delivery to tumor in patients with glioma: comparison of intracarotid and intravenous administration.

1 reference

12 December 2020

Epidermal growth factor ligand-independent, unregulated, cell-transforming potential of a naturally occurring human mutant EGFRvIII gene.

1 reference

12 December 2020

Pharmacokinetics and dose estimates following intrathecal administration of 131I-monoclonal antibodies for the treatment of central nervous system malignancies.

1 reference

12 December 2020

Biologic properties of a CH2 domain-deleted recombinant immunoglobulin

1 reference

12 December 2020

Gene Amplification in Malignant Human Gliomas: Clinical and Histopathologic Aspects

1 reference

12 December 2020

Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts.

1 reference

12 December 2020

Integrated microscopic-macroscopic pharmacology of monoclonal antibody radioconjugates: the radiation dose distribution.

1 reference

12 December 2020

Insulin-like growth factor-I receptors in human glial tumors

1 reference

12 December 2020

Microautoradiographic analysis of the normal organ distribution of radioiodinated single-chain Fv and other immunoglobulin forms.

1 reference

12 December 2020

Modeling analysis of the global and microscopic distribution of immunoglobulin G, F(ab')2, and Fab in tumors

1 reference

12 December 2020

Convection-enhanced distribution of large molecules in gray matter during interstitial drug infusion

1 reference

12 December 2020

Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis.

1 reference

12 December 2020

Oncogenes and anti-oncogenes in human central nervous system tumors

1 reference

12 December 2020

Prognostic implications of p53 protein, epidermal growth factor receptor, and Ki-67 labelling in brain tumours

1 reference

12 December 2020

Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells

1 reference

12 December 2020

In situ cyclopentenyl cytosine infusion for the treatment of experimental brain tumors

1 reference

12 December 2020

Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification

1 reference

12 December 2020

Highly specific in vivo tumor targeting by monovalent and divalent forms of 741F8 anti-c-erbB-2 single-chain Fv

1 reference

12 December 2020

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1 reference

12 December 2020

Inhibition of tumor growth by a monoclonal antibody reactive with an oncogene-encoded tumor antigen

1 reference

12 December 2020

Experimental approaches to increase radiolabeled antibody localization in tumors.

1 reference

12 December 2020

Mechanism of antitumor activity in mice for anti-epidermal growth factor receptor monoclonal antibodies with different isotypes

1 reference

12 December 2020

Insulin and insulin-like growth factor I in brain tumors: binding and in vitro effects.

1 reference

12 December 2020

Prognostic significance of the c-erbB-2 oncogene product in childhood medulloblastoma

1 reference

12 December 2020

Rate of internalization of an immunotoxin correlates with cytotoxic activity against human tumor cells

1 reference

12 December 2020

The epidermal growth factor receptor as a target for therapy with antireceptor monoclonal antibodies

1 reference

12 December 2020

Clinical development of 2B1, a bispecific murine monoclonal antibody targeting c-erbB-2 and Fc gamma RIII.

1 reference

12 December 2020

Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies

1 reference

12 December 2020

Immunotherapy and monoclonal antibody therapies

1 reference

12 December 2020

Mouse/human chimeric monoclonal antibody in man: kinetics and immune response

1 reference

12 December 2020

Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma

1 reference

12 December 2020

Generation and characterization of a mouse/human chimeric antibody directed against extracellular matrix protein tenascin

1 reference

12 December 2020

Functional characterization of an EGF receptor with a truncated extracellular domain expressed in glioblastomas with EGFR gene amplification

1 reference

12 December 2020

Cytotoxicity against human tumor cells mediated by the conjugate of anti-epidermal growth factor receptor monoclonal antibody to recombinant ricin A chain

1 reference

12 December 2020

Tumor-specific anti-epidermal growth factor receptor variant III monoclonal antibodies: use of the tyramine-cellobiose radioiodination method enhances cellular retention and uptake in tumor xenografts.

1 reference

12 December 2020

Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene

1 reference

12 December 2020

Identifiers

DOI

10.1023/A:1005812417638

1 reference

PubMed ID

9440024

Dimensions Publication ID

7 October 2017

0 references

1 reference

PubMed ID

9440024