(Q41710782)

7 October 2017

title

IL-1 mediates amyloid-associated islet dysfunction and inflammation in human islet amyloid polypeptide transgenic mice (English)

1 reference

7 October 2017

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25491100%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Jan A Ehses

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25491100%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Bruce C Verchere

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25491100%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

author name string

Clara Y Westwell-Roper

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25491100%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Cyrus A Chehroudi

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25491100%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Jaques A Courtade

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25491100%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

publication date

10 December 2014

1 reference

7 October 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25491100%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

volume

58

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25491100%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25491100%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

page(s)

575-585

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25491100%20AND%20SRC:MED&resulttype=core&format=json

Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes

11 June 2020

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Toll-like receptors and NLRP3 as central regulators of pancreatic islet inflammation in type 2 diabetes

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Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide

21 January 2018

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Resident macrophages mediate islet amyloid polypeptide-induced islet IL-1β production and β-cell dysfunction.

21 January 2018

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IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction.

21 January 2018

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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

21 January 2018

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Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes

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21 January 2018

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Transposable elements: targets for early nutritional effects on epigenetic gene regulation

21 January 2018

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Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes

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21 January 2018

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Neutralizing interleukin-1beta (IL-1beta) induces beta-cell survival by maintaining PDX1 protein nuclear localization

21 January 2018

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beta-Cell-specific overexpression of glutathione peroxidase preserves intranuclear MafA and reverses diabetes in db/db mice

21 January 2018

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Metabolic stress, IAPP and islet amyloid

21 January 2018

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Transcriptional and translational regulation of cytokine signaling in inflammatory β-cell dysfunction and apoptosis

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Activating the NLRP3 inflammasome using the amyloidogenic peptide IAPP.

21 January 2018

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21 January 2018

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Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid

21 January 2018

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Islet amyloid formation is an important determinant for inducing islet inflammation in high-fat-fed human IAPP transgenic mice

21 January 2018

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21 January 2018

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The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

21 January 2018

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Activation of innate immunity by lysozyme fibrils is critically dependent on cross-β sheet structure.

21 January 2018

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Inhibition of MafA transcriptional activity and human insulin gene transcription by interleukin-1beta and mitogen-activated protein kinase kinase kinase in pancreatic islet beta cells

21 January 2018

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IL-1 produced and released endogenously within human islets inhibits beta cell function

21 January 2018

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Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets

21 January 2018

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IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat

21 January 2018

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21 January 2018

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21 January 2018

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Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death

21 January 2018

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Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release

21 January 2018

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The prohormone convertase enzyme 2 (PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal cleavage site

21 January 2018

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Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide in {beta}-cells

21 January 2018

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Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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12 December 2020

Amyloid fibril formation is progressive and correlates with beta-cell secretion in transgenic mouse isolated islets

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12 December 2020

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12 December 2020

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12 December 2020

Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide

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12 December 2020