(Q41713118)

14 June 2018

title

Novel residues in avian influenza virus PB2 protein affect virulence in mammalian hosts (English)

1 reference

14 June 2018

1 reference

10

Yoshihiro Kawaoka

1 reference

14 June 2018

9

Gabriele Neumann

1 reference

14 June 2018

Masato Hatta

2

Masato Hatta

1 reference

14 June 2018

Peter J Halfmann

4

Peter Halfmann

1 reference

14 June 2018

Shufang Fan

1

Shufang Fan

1 reference

14 June 2018

Masaki Imai

5

Masaki Imai

1 reference

14 June 2018

Catherine Macken

6

Catherine A Macken

1 reference

14 June 2018

author name string

Jin Hyun Kim

3

1 reference

14 June 2018

Mai Quynh Le

7

1 reference

14 June 2018

Tung Nguyen

8

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14 June 2018

language of work or name

English

0 references

publication date

7 October 2014

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14 June 2018

published in

Nature Communications

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14 June 2018

volume

5

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14 June 2018

page(s)

5021

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14 June 2018

PB2-588I enhances 2009 H1N1 pandemic influenza virus virulence by increasing viral replication and exacerbating PB2 inhibition of beta interferon expression.

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1 reference

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Structural and Functional Characterization of K339T Substitution Identified in the PB2 Subunit Cap-binding Pocket of Influenza A Virus

15 June 2018

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Mouse-adapted H9N2 influenza A virus PB2 protein M147L and E627K mutations are critical for high virulence

15 June 2018

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Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells

15 June 2018

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Indications that live poultry markets are a major source of human H5N1 influenza virus infection in China

15 June 2018

1 reference

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Genetic characterization and pathogenicity assessment of highly pathogenic H5N1 avian influenza viruses isolated from migratory wild birds in 2011, South Korea

15 June 2018

1 reference

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Influence of PB2 host-range determinants on the intranuclear mobility of the influenza A virus polymerase

15 June 2018

1 reference

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Impact of amino acid mutations in PB2, PB1-F2, and NS1 on the replication and pathogenicity of pandemic (H1N1) 2009 influenza viruses

15 June 2018

1 reference

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Influenza A virus NS1 gene mutations F103L and M106I increase replication and virulence

15 June 2018

1 reference

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Biological and Structural Characterization of a Host-Adapting Amino Acid in Influenza Virus

15 June 2018

1 reference

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Continued evolution of H5N1 influenza viruses in wild birds, domestic poultry, and humans in China from 2004 to 2009.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

Identification of amino acids in HA and PB2 critical for the transmission of H5N1 avian influenza viruses in a mammalian host

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

Role of host-specific amino acids in the pathogenicity of avian H5N1 influenza viruses in mice

15 June 2018

1 reference

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Adaptive strategies of the influenza virus polymerase for replication in humans

15 June 2018

1 reference

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15 June 2018

1 reference

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In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses

15 June 2018

1 reference

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Emergence and pandemic potential of swine-origin H1N1 influenza virus

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

The structural basis for cap binding by influenza virus polymerase subunit PB2

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

A new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicity

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

A single-amino-acid substitution in the NS1 protein changes the pathogenicity of H5N1 avian influenza viruses in mice

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

A single mutation in the PB1-F2 of H5N1 (HK/97) and 1918 influenza A viruses contributes to increased virulence

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

Clustal W and Clustal X version 2.0

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

The NS1 gene contributes to the virulence of H5N1 avian influenza viruses

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western China

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

Molecular basis of replication of duck H5N1 influenza viruses in a mammalian mouse model

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

Avian influenza (H5N1) viruses isolated from humans in Asia in 2004 exhibit increased virulence in mammals

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

The evolution of H5N1 influenza viruses in ducks in southern China

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

Lethal H5N1 influenza viruses escape host anti-viral cytokine responses

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

Generation of influenza A viruses entirely from cloned cDNAs

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

Mx proteins: mediators of innate resistance to RNA viruses

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

A single amino acid in the PB2 gene of influenza A virus is a determinant of host range.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

Sequence requirements for cleavage activation of influenza virus hemagglutinin expressed in mammalian cells

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

Avian-to-human transmission of the PB1 gene of influenza A viruses in the 1957 and 1968 pandemics

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

Efficient selection for high-expression transfectants with a novel eukaryotic vector

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

New avian influenza virus (H5N1) in wild birds, Qinghai, China.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

Pathogenicity of highly pathogenic avian H5N1 influenza A viruses isolated from humans between 2003 and 2008 in northern Vietnam

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

Characterization of avian influenza viruses A (H5N1) from wild birds, Hong Kong, 2004-2008.

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

A naturally occurring deletion in its NS gene contributes to the attenuation of an H5N1 swine influenza virus in chickens

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

Evolution of highly pathogenic avian H5N1 influenza viruses and the emergence of dominant variants

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

Two amino acid residues in the matrix protein M1 contribute to the virulence difference of H5N1 avian influenza viruses in mice

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

Homology modeling and examination of the effect of the D92E mutation on the H5N1 nonstructural protein NS1 effector domain

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5841464

18 August 2018

Identifiers

DOI

10.1038/NCOMMS6021

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14 June 2018

0 references

1 reference

14 June 2018

PubMed publication ID

25289523

1 reference

14 June 2018