(Q41736499)

8 October 2017

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title

Predicting functions from protein sequences--where are the bottlenecks? (English)

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protein function prediction

8 October 2017

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author

Peer Bork

series ordinal

1

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8 October 2017

2

Koonin EV

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8 October 2017

language of work or name

English

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publication date

1 April 1998

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8 October 2017

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8 October 2017

18

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8 October 2017

4

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8 October 2017

313-318

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https://scigraph.springernature.com/pub.10.1038/ng0498-313

8 October 2017

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cites work

Go hunting in sequence databases but watch out for the traps.

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Dealing with database explosion: a cautionary note.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Issues in searching molecular sequence databases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Perspectives: sequence data base searching in the era of large-scale genomic sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

A genomic perspective on protein families

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

21 January 2018

Gene discovery in dbEST.

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Ancient conserved regions in new gene sequences and the protein databases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

The complete DNA sequence of yeast chromosome III

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Regional base composition variation along yeast chromosome III: evolution of chromosome primary structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Applying motif and profile searches

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Analysis of compositionally biased regions in sequence databases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Predicting coiled-coil regions in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Gene families: the taxonomy of protein paralogs and chimeras

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Positional cloning of the mouse obese gene and its human homologue

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Threading analysis suggests that the obese gene product may be a helical cytokine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Crystal structure of the obese protein leptin-E100

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Protein fold recognition by prediction-based threading

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Invasive Strategies to Achieve Infarct-Related Artery Patency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Assigning folds to the proteins encoded by the genome of Mycoplasma genitalium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Distinguishing Homologous from Analogous Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Uses for evolutionary trees

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

SAM as a protein interaction domain involved in developmental regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

A novel protein with strong homology to the tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Exploring the Mycoplasma capricolum genome: a minimal cell reveals its physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Metabolism and evolution of Haemophilus influenzae deduced from a whole-genome comparison with Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Gene expression profiles in normal and cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

The WW domain: a signalling site in dystrophin?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

ZZ and TAZ: new putative zinc fingers in dystrophin and other proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Structure of the WW domain of a kinase-associated protein complexed with a proline-rich peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

HEAT repeats in the Huntington's disease protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

BRCA1 protein products ... Functional motifs...

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Evidence for a transcriptional activation function of BRCA1 C-terminal region

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Identification of the breast cancer susceptibility gene BRCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Internal repeats in the BRCA2 protein sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

The BRC repeats are conserved in mammalian BRCA2 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Cloning of a gene that is rearranged in patients with choroideraemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Structural insights into the function of the Rab GDI superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Friedreich's ataxia protein: phylogenetic evidence for mitochondrial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Deciphering the cause of Friedreich ataxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

The skeletal muscle chloride channel in dominant and recessive human myotonia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

A novel X-linked gene, G4.5. is responsible for Barth syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Barth syndrome may be due to an acyltransferase deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Biochemistry and genetics of eukaryotic mismatch repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

An atypical topoisomerase II from Archaea with implications for meiotic recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Positional cloning of the Werner's syndrome gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Comparative sequence analysis of ribonucleases HII, III, II PH and D

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

A putative nucleic acid-binding domain in Bloom's and Werner's syndrome helicases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

The Bloom's syndrome gene product is homologous to RecQ helicases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Identification of homer as a homologue of the Wiskott-Aldrich syndrome protein suggests a receptor-binding function for WH1 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

Yeast chromosome III: new gene functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

7 January 2021

ORFs and genes: how strong a connection?

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

7 January 2021

Positional cloning moves from perditional to traditional

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

7 January 2021

SMART, a simple modular architecture research tool: identification of signaling domains

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

7 January 2021

Current limitations to protein threading approaches

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

7 January 2021

Functional genomics: it's all how you read it

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

7 January 2021

From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

7 January 2021

Human choroideremia protein contains a FAD-binding domain

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

7 January 2021

The structure of a domain common to archaebacteria and the homocystinuria disease protein

1 reference

https://api.crossref.org/works/10.1038%2FNG0498-313

7 January 2021

Identifiers

DOI

10.1038/NG0498-313

1 reference

Dimensions Publication ID

8 October 2017

1021131638

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Fatcat ID

release_kcfiq3rgcnaxjmc7bozwl3o4h4

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/kcfiq3rgcnaxjmc7bozwl3o4h4

24 November 2022

mapped directly with Wikidata item

1 reference