(Q41761571)

9 October 2017

Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis (English)

1 reference

9 October 2017

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Weilan Ye

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

9

Jim Nonomiya

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

author name string

Terry D Crawford

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Huifen Chen

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Jason W Boggs

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Joy Drobnick

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Seth F Harris

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Rajiv Jesudason

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Erin McNamara

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Amy Sambrone

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Stephen Schmidt

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Tanya Smyczek

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Philip Vitorino

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Lan Wang

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Ping Wu

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Stacey Yeung

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Jinhua Chen

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Kevin Chen

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Charles Z Ding

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Tao Wang

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Zijin Xu

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Lesley J Murray

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Stephen E Gould

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

publication date

29 June 2015

1 reference

ACS Medicinal Chemistry Letters

9 October 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

volume

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

page(s)

913-918

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

CNS drug design: balancing physicochemical properties for optimal brain exposure

1 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538449

Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538449

Discovery of selective 4-Amino-pyridopyrimidine inhibitors of MAP4K4 using fragment-based lead identification and optimization

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538449

MINK and TNIK differentially act on Rap2-mediated signal transduction to regulate neuronal structure and AMPA receptor function

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538449

Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538449

Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538449

Role of the active-site solvent in the thermodynamics of factor Xa ligand binding

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538449

Identification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screen

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538449

Motifs for molecular recognition exploiting hydrophobic enclosure in protein-ligand binding

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538449

Coordinated cell-shape changes control epithelial movement in zebrafish and Drosophila

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538449

An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARgamma, adipogenesis, and insulin-responsive hexose transport

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538449

The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538449

Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538449

A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538449

Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538449

MAP4K4 regulates integrin-FERM binding to control endothelial cell motility

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538449

Pharmacologic characterization of a kinetic in vitro human co-culture angiogenesis model using clinically relevant compounds

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538449

Use of the cassette-dosing approach to assess brain penetration in drug discovery.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538449

Understanding the impact of the P-loop conformation on kinase selectivity.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538449

Expression of MAP4K4 is associated with worse prognosis in patients with stage II pancreatic ductal adenocarcinoma

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538449

Strategies to optimize the brain availability of central nervous system drug candidates

18 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26288693

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ACSMEDCHEMLETT.5B00174

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26288693%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

PubMed publication ID

26288693

1 reference