(Q41806994)

English

Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity

scientific article published on May 1998

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity (English)

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

1 reference

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author name string

G Smith

1

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

S Modi

2

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

I Pillai

3

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

L Y Lian

4

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

M J Sutcliffe

5

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

M P Pritchard

6

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

T Friedberg

7

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

G C Roberts

8

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

C R Wolf

9

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

language of work or name

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publication date

1 May 1998

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Europe PubMed Central

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12 October 2017

Biochemical Journal

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Europe PubMed Central

PMC publication ID

12 October 2017

331 ( Pt 3)

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Europe PubMed Central

PMC publication ID

12 October 2017

783-792

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

Protein measurement with the Folin phenol reagent

1 reference

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6 June 2018

THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE

1 reference

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6 June 2018

An automated approach for defining core atoms and domains in an ensemble of NMR-derived protein structures

1 reference

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6 June 2018

Coexpression of a human P450 (CYP3A4) and P450 reductase generates a highly functional monooxygenase system in Escherichia coli.

1 reference

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6 June 2018

A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding

1 reference

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6 June 2018

Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's

1 reference

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6 June 2018

Comparative protein modelling by satisfaction of spatial restraints

1 reference

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6 June 2018

Crystal structure and refinement of cytochrome P450terp at 2.3 A resolution

1 reference

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6 June 2018

Clinical implications of genetic polymorphism in drug metabolism

1 reference

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6 June 2018

Structure of cytochrome P450eryF involved in erythromycin biosynthesis

1 reference

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6 June 2018

NMR studies of substrate binding to cytochrome P450 BM3: comparisons to cytochrome P450 cam.

1 reference

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6 June 2018

Effect of replacement of ferriprotoporphyrin IX in the haem domain of cytochrome P-450 BM-3 on substrate binding and catalytic activity

1 reference

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6 June 2018

Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

Pretranslational regulation of sex-dependent testosterone hydroxylases by growth hormone in mouse liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

Crystal structure of substrate-free Pseudomonas putida cytochrome P-450

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

High-resolution crystal structure of cytochrome P450cam

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

Rapid and efficient site-specific mutagenesis without phenotypic selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

Amplification and increased expression of alpha class glutathione S-transferase-encoding genes associated with resistance to nitrogen mustards

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

The molecular biology of cytochrome P450s.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16) alpha) in mouse liver: cDNA sequences, neonatal imprinting, and reversible regulation by androgen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

Functional characterization of two cytochrome P-450s within the mouse, male-specific steroid 16 alpha-hydroxylase gene family: expression in mammalian cells and chimeric proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

Microbial cytochromes P-450 and xenobiotic metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

The surface-exposed tyrosine residue Tyr83 of pea plastocyanin is involved in both binding and electron transfer reactions with cytochrome f

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

A three-dimensional molecular template for substrates of human cytochrome P450 involved in debrisoquine 4-hydroxylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

Relationship between the debrisoquine hydroxylase polymorphism and cancer susceptibility.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

The Protein Data Bank: a computer-based archival file for macromolecular structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

1 reference

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6 June 2018

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications

1 reference

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6 June 2018

DNA sequencing with chain-terminating inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

A general strategy for the expression of recombinant human cytochrome P450s in Escherichia coli using bacterial signal peptides: expression of CYP3A4, CYP2A6, and CYP2E1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

18 August 2018

Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization.

1 reference

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18 August 2018

Nomenclature for human CYP2D6 alleles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

18 August 2018

Structure and function of cytochromes P450: a comparative analysis of three crystal structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

18 August 2018

Mouse liver testosterone 16 alpha-hydroxylase (cytochrome P-450(16) alpha). Purification, regioselectivity, stereospecificity, and immunochemical characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic polymorphism in drug oxidation: in vitro studies of human debrisoquine 4-hydroxylase and bufuralol 1'-hydroxylase activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate specificity of human liver cytochrome P-450 debrisoquine 4-hydroxylase probed using immunochemical inhibition and chemical modeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-performance liquid chromatographic assays for bufuralol 1'-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Probing Structure-Function Relations in Heme-Containing Oxygenases and Peroxidases

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate specificities of cytochrome P-450, C-P-450(16)alpha and P-450(15)alpha, and contribution to steroid hydroxylase activities in mouse liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A predictive model for substrates of cytochrome P450-debrisoquine (2D6)

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A preliminary 3D model for cytochrome P450 2D6 constructed by homology model building

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of cytochrome P450 2D6 in Escherichia coli, purification, and spectral and catalytic characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4--implications for susceptibility to Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine as a Substrate of Cytochrome P450 2D6: Allosteric Effects of NADPH−Cytochrome P450 Reductase†

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ3310783

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

ResearchGate publication ID

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