(Q41833192)

English

Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo

scientific article published on 18 March 2009

In more languages

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scholarly article

1 reference

Europe PubMed Central

12 October 2017

Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo (English)

1 reference

Europe PubMed Central

12 October 2017

connective tissue

1 reference

based on heuristic

inferred from title

author name string

David R Brigstock

1

1 reference

Europe PubMed Central

12 October 2017

publication date

18 March 2009

1 reference

Europe PubMed Central

12 October 2017

Journal of Cell Communication and Signaling

1 reference

Europe PubMed Central

12 October 2017

3

1 reference

Europe PubMed Central

12 October 2017

1

1 reference

Europe PubMed Central

12 October 2017

5-18

1 reference

Europe PubMed Central

12 October 2017

https://scigraph.springernature.com/pub.10.1007/s12079-009-0043-9

0 references

Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease?

1 reference

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Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis

1 reference

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Advances in antifibrotic therapy

1 reference

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Effect of all-trans retinoic acid on liver fibrosis induced by common bile duct ligation in rats

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Regulation of CCN2 mRNA expression and promoter activity in activated hepatic stellate cells

1 reference

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6 June 2018

Functions and mechanisms of action of CCN matricellular proteins

1 reference

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The Starbuck stops here: it's a Smad world

1 reference

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RNA interfering connective tissue growth factor prevents rat hepatic stellate cell activation and extracellular matrix production

1 reference

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6 June 2018

Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage

1 reference

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6 June 2018

Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways

1 reference

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6 June 2018

CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes

1 reference

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Analysis of CCN2 promoter activity in PANC-1 cells: regulation by ras/MEK/ERK

1 reference

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6 June 2018

Connective tissue growth factor is necessary for retinal capillary basal lamina thickening in diabetic mice

1 reference

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Disruption of connective tissue growth factor by short hairpin RNA inhibits collagen synthesis and extracellular matrix secretion in hepatic stellate cells

1 reference

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6 June 2018

Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis

1 reference

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6 June 2018

Focal adhesion kinase/Src suppresses early chondrogenesis: central role of CCN2.

1 reference

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6 June 2018

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonists attenuate the profibrotic response induced by TGF-beta1 in renal interstitial fibroblasts

1 reference

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Connective tissue growth factor/CCN2-null mouse embryonic fibroblasts retain intact transforming growth factor-beta responsiveness

1 reference

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Cell-specific delivery of a transforming growth factor-beta type I receptor kinase inhibitor to proximal tubular cells for the treatment of renal fibrosis

1 reference

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PPAR-gamma agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosis

1 reference

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Functional requirement of CCN2 for intramembranous bone formation in embryonic mice

1 reference

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6 June 2018

Angiogenesis is not impaired in connective tissue growth factor (CTGF) knock-out mice

1 reference

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6 June 2018

Transforming growth factor-beta and fibrosis

1 reference

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Tissue-specific mechanisms for CCN2/CTGF persistence in fibrotic gingiva: interactions between cAMP and MAPK signaling pathways, and prostaglandin E2-EP3 receptor mediated activation of the c-JUN N-terminal kinase

1 reference

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6 June 2018

Connective tissue growth factor expression is regulated by histamine in lung fibroblasts: potential role of histamine in airway remodeling.

1 reference

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High glucose upregulates connective tissue growth factor expression in human vascular smooth muscle cells

1 reference

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Synergistic effects of pravastatin and pioglitazone in renal tubular epithelial cells induced by transforming growth factor-beta1.

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Pathogenic role of connective tissue growth factor (CTGF/CCN2) in osteolytic metastasis of breast cancer

1 reference

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Intrinsic biological activity of the thrombospondin structural homology repeat in connective tissue growth factor

1 reference

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A novel integrin alpha5beta1 binding domain in module 4 of connective tissue growth factor (CCN2/CTGF) promotes adhesion and migration of activated pancreatic stellate cells

1 reference

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Role of connective tissue growth factor in oval cell response during liver regeneration after 2-AAF/PHx in rats

1 reference

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Structural and functional properties of CCN proteins

1 reference

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Simvastatin inhibits growth factor expression and modulates profibrogenic markers in lung fibroblasts.

1 reference

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Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction

1 reference

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CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin

1 reference

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Connective tissue growth factor expression and induction by transforming growth factor-beta is abrogated by simvastatin via a Rho signaling mechanism

1 reference

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Differential effects of simvastatin on mesangial cells

1 reference

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TGF-beta signaling and the fibrotic response

1 reference

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Hammerhead ribozyme targeting connective tissue growth factor mRNA blocks transforming growth factor-beta mediated cell proliferation.

1 reference

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Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha(v)beta(3) and heparan sulfate proteoglycan

1 reference

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The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology

1 reference

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Connective tissue growth factor participates in scar formation of crescentic glomerulonephritis.

1 reference

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Roles of connective tissue growth factor and prostanoids in early streptozotocin-induced diabetic rat kidney: the effect of aspirin treatment

1 reference

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Role of connective tissue growth factor in breast implant elastomer capsular formation

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Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development

1 reference

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Comparison of Prostaglandin F2α, Bimatoprost (Prostamide), and Butaprost (EP2 Agonist) on Cyr61 and Connective Tissue Growth Factor Gene Expression

1 reference

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Connective Tissue Growth Factor Expression and Action in Human Corneal Fibroblast Cultures and Rat Corneas after Photorefractive Keratectomy

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Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts

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Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy?

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Role of prostaglandin E(2) EP receptors and cAMP in the expression of connective tissue growth factor

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1 reference

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Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients

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Regulation of connective tissue growth factor (ccn2; ctgf) gene expression in human mesangial cells: modulation by HMG CoA reductase inhibitors (statins).

1 reference

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Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblasts

1 reference

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Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model

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Transforming growth factor beta induces anchorage-independent growth of NRK fibroblasts via a connective tissue growth factor-dependent signaling pathway.

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Ethanol-mediated expression of connective tissue growth factor (CCN2) in mouse pancreatic stellate cells

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9-Cis-retinoic acid exhibits antifibrotic activity via the induction of cyclooxygenase-2 expression and prostaglandin E2 production in scleroderma fibroblasts

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Connective tissue growth factor modulates extracellular matrix production in human subconjunctival fibroblasts and their proliferation and migration in vitro.

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Effect of small interfering RNA on the expression of connective tissue growth factor and type I and III collagen in skin fibroblasts of patients with systemic sclerosis.

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Rosiglitazone inhibits angiotensin II-induced CTGF expression in vascular smooth muscle cells - role of PPAR-gamma in vascular fibrosis.

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CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts

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Connective tissue growth factor (CCN2) in rat pancreatic stellate cell function: integrin alpha5beta1 as a novel CCN2 receptor

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2686750

18 August 2018

PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2686750

18 August 2018

Reduction in connective tissue growth factor by antisense treatment ameliorates renal tubulointerstitial fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2686750

18 August 2018

Connective tissue growth factor induces c-fos gene activation and cell proliferation through p44/42 MAP kinase in primary rat hepatic stellate cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2686750

18 August 2018

Connective tissue growth factor siRNA modulates mRNA levels for a subset of molecules in normal and TGF-beta 1-stimulated porcine skin fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2686750

18 August 2018

Down-regulation of connective tissue growth factor and type I collagen mRNA expression by connective tissue growth factor antisense oligonucleotide during experimental liver fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2686750

18 August 2018

Fluvastatin prevents nephropathy likely through suppression of connective tissue growth factor-mediated extracellular matrix accumulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2686750

18 August 2018

Pravastatin treatment attenuates interstitial inflammation and fibrosis in a rat model of chronic cyclosporine-induced nephropathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2686750

18 August 2018

Expression of connective tissue growth factor in bone: its role in osteoblast proliferation and differentiation in vitro and bone formation in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2686750

18 August 2018

Prostacyclin derivatives prevent the fibrotic response to TGF-beta by inhibiting the Ras/MEK/ERK pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2686750

18 August 2018

Connective Tissue Growth Factor Expressed in Tubular Epithelium Plays a Pivotal Role in Renal Fibrogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2686750

2 December 2018

Role of connective tissue growth factor in profibrotic action of transforming growth factor-beta: a potential target for preventing renal fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Connective tissue growth factor-specific antibody attenuates tumor growth, metastasis, and angiogenesis in an orthotopic mouse model of pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Connective tissue growth factor causes persistent proalpha2(I) collagen gene expression induced by transforming growth factor-beta in a mouse fibrosis model

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting siRNA to arrest fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of TGF-β1-induced connective tissue growth factor expression in airway smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Attachment of articular cartilage chondrocytes to the tissue form of type VI collagen

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Successful Targeting to Rat Hepatic Stellate Cells Using Albumin Modified with Cyclic Peptides That Recognize the Collagen Type VI Receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of connective tissue growth factor expression by prostaglandin E(2)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nephroprotective effect of the HMG-CoA-reductase inhibitor cerivastatin in a mouse model of progressive renal fibrosis in Alport syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Connective tissue growth factor and fibronectin secretion in renal tubular epithelial cells induced by TGF-beta1: suppressive effects of troglitazone

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPAR gamma inhibits growth of rat hepatic stellate cells and TGF beta-induced connective tissue growth factor expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of connective tissue growth factor in fibronectin expression and tubulointerstitial fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HMG-CoA Reductase Inhibitors Decrease Angiotensin II–Induced Vascular Fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with Smad3

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluvastatin reduces renal fibroblast proliferation and production of type III collagen: therapeutic implications for tubulointerstitial fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutralizing monoclonal antibody to human connective tissue growth factor ameliorates transforming growth factor-beta-induced mouse fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phosphodiesterase 4 inhibitor inhibits matrix protein deposition in airways in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of CTGF, a hypertrophic chondrocyte-specific gene product, in tumor angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pravastatin Inhibits the Rho/CCN2/extracellular matrix cascade in human fibrosis explants and improves radiation-induced intestinal fibrosis in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of connective tissue growth factor by siRNA prevents liver fibrosis in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TNF-alpha, but not IFN-gamma, regulates CCN2 (CTGF), collagen type I, and proliferation in mesangial cells: possible roles in the progression of renal fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S12079-009-0043-9

1 reference

Europe PubMed Central

12 October 2017

1 reference

Europe PubMed Central

12 October 2017

1 reference

Europe PubMed Central

12 October 2017

ResearchGate publication ID

0 references

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