(Q41838621)

English

Constitutive activation of the G-protein subunit Galphas within forebrain neurons causes PKA-dependent alterations in fear conditioning and cortical Arc mRNA expression.

scientific article published on 28 January 2008

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scholarly article

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1 January 2020

Constitutive activation of the G-protein subunit Galphas within forebrain neurons causes PKA-dependent alterations in fear conditioning and cortical Arc mRNA expression (English)

1 reference

Europe PubMed Central

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1 January 2020

Steven J. Siegel

4

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1 January 2020

Miles D. Houslay

6

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1 January 2020

7

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1 January 2020

1

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1 January 2020

Christopher G. Favilla

3

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1 January 2020

author name string

York-Fong Cheung

2

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1 January 2020

Stephen J Kanes

5

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1 January 2020

publication date

28 January 2008

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1 January 2020

Learning and Memory

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1 January 2020

15

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1 January 2020

2

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1 January 2020

75-83

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Europe PubMed Central

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1 January 2020

Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels.

1 reference

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Chronically increased Gsalpha signaling disrupts associative and spatial learning.

1 reference

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6 June 2018

PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases

1 reference

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6 June 2018

Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2216679

6 June 2018

Constitutive activation of Galphas within forebrain neurons causes deficits in sensorimotor gating because of PKA-dependent decreases in cAMP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2216679

6 June 2018

Pde1 phosphodiesterase modulates cyclic AMP levels through a protein kinase A-mediated negative feedback loop in Cryptococcus neoformans

1 reference

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6 June 2018

Keynote review: phosphodiesterase-4 as a therapeutic target

1 reference

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6 June 2018

The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2216679

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Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents

1 reference

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6 June 2018

RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2216679

6 June 2018

Memory-influencing intra-basolateral amygdala drug infusions modulate expression of Arc protein in the hippocampus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2216679

6 June 2018

Mesolimbic dopaminergic pathways in fear conditioning

1 reference

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6 June 2018

Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP.

1 reference

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A distinct role for norepinephrine in memory retrieval

1 reference

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6 June 2018

Removal of G(ialpha1) constraints on adenylyl cyclase in the hippocampus enhances LTP and impairs memory formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2216679

6 June 2018

A mouse model of Rubinstein-Taybi syndrome: defective long-term memory is ameliorated by inhibitors of phosphodiesterase 4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2216679

6 June 2018

Cyclic AMP compartmentation due to increased cAMP-phosphodiesterase activity in transgenic mice with a cardiac-directed expression of the human adenylyl cyclase type 8 (AC8).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2216679

6 June 2018

Experience-dependent regulation of the immediate-early gene arc differs across brain regions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2216679

6 June 2018

cAMP effector mechanisms. Novel twists for an 'old' signaling system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2216679

6 June 2018

Mnemonic functions of dorsal striatum and hippocampus in aversive conditioning

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2216679

6 June 2018

CREB, memory enhancement and the treatment of memory disorders: promises, pitfalls and prospects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2216679

6 June 2018

PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2216679

6 June 2018

The human hippocampus and spatial and episodic memory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2216679

6 June 2018

Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2216679

6 June 2018

Phosphodiesterase 4D and protein kinase a type II constitute a signaling unit in the centrosomal area

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2216679

6 June 2018

Proteomic analysis of NMDA receptor-adhesion protein signaling complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2216679

6 June 2018

Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2216679

6 June 2018

Calcium-stimulated adenylyl cyclase activity is critical for hippocampus-dependent long-term memory and late phase LTP

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2216679

6 June 2018

Effects of age on the generalization and incubation of memory in the F344 rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2216679

6 June 2018

The PDE1-encoded low-affinity phosphodiesterase in the yeast Saccharomyces cerevisiae has a specific function in controlling agonist-induced cAMP signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2216679

6 June 2018

Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2216679

6 June 2018

Characterization of an intronic promoter of a cyclic adenosine 3',5'-monophosphate (cAMP)-specific phosphodiesterase gene that confers hormone and cAMP inducibility.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2216679

6 June 2018

Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2216679

6 June 2018

Associative learning disrupted by impaired Gs signaling in Drosophila mushroom bodies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2216679

6 June 2018

Differential expression of the 61 kDa and 63 kDa calmodulin-dependent phosphodiesterases in the mouse brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2216679

6 June 2018

Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2216679

6 June 2018

Somatodendritic expression of an immediate early gene is regulated by synaptic activity

1 reference

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6 June 2018

Induction of Ca2+/calmodulin-stimulated cyclic AMP phosphodiesterase (PDE1) activity in Chinese hamster ovary cells (CHO) by phorbol 12-myristate 13-acetate and by the selective overexpression of protein kinase C isoforms

1 reference

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6 June 2018

Loss of calcium/calmodulin responsiveness in adenylate cyclase of rutabaga, a Drosophila learning mutant

1 reference

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6 June 2018

Calmodulin and Ca2+-dependent phosphorylation and dephosphorylation of 63-kDa subunit-containing bovine brain calmodulin-stimulated cyclic nucleotide phosphodiesterase isozyme.

1 reference

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6 June 2018

Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning

1 reference

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6 June 2018

Environmental complexity affects contextual fear conditioning following hippocampal lesions in rats.

1 reference

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18 August 2018

A thalamo-cortico-amygdala pathway mediates auditory fear conditioning in the intact brain.

1 reference

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18 August 2018

Amygdala regulation of immediate-early gene expression in the hippocampus induced by contextual fear conditioning.

1 reference

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18 August 2018

Topography of Arc/Arg3.1 mRNA expression in the dorsal and ventral hippocampus induced by recent and remote spatial memory recall: dissociation of CA3 and CA1 activation.

1 reference

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18 August 2018

Effects of pre- or post-training entorhinal cortex AP5 injection on fear conditioning

1 reference

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18 August 2018

Subchronic rolipram delivery activates hippocampal CREB and arc, enhances retention and slows down extinction of conditioned fear.

1 reference

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Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases

1 reference

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18 August 2018

Inhibition of the phosphodiesterase 4 (PDE4) enzyme reverses memory deficits produced by infusion of the MEK inhibitor U0126 into the CA1 subregion of the rat hippocampus

1 reference

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18 August 2018

Footshock intensity and generalization in contextual and auditory-cued fear conditioning in the rat.

1 reference

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1 reference

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18 August 2018

Effects of dorsal striatum lesions in tone fear conditioning and contextual fear conditioning.

1 reference

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1 reference

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18 August 2018

Inbred mouse strain differences in the establishment of long-term fear memory.

1 reference

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18 August 2018

Cyclic nucleotide research -- still expanding after half a century

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18 August 2018

Ibotenate Lesions of Hippocampus and/or Subiculum: Dissociating Components of Allocentric Spatial Learning.

1 reference

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18 August 2018

Acquisition of a novel behavior induces higher levels of Arc mRNA than does overtrained performance.

1 reference

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18 August 2018

An immediate-shock freezing deficit with discrete cues: a possible role for unconditioned stimulus processing mechanisms.

1 reference

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18 August 2018

Arg3.1/Arc mRNA induction by Ca2+ and cAMP requires protein kinase A and mitogen-activated protein kinase/extracellular regulated kinase activation.

1 reference

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18 August 2018

Experience-dependent gene expression in the rat hippocampus after spatial learning: a comparison of the immediate-early genes Arc, c-fos, and zif268.

1 reference

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18 August 2018

Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles.

1 reference

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18 August 2018

A mitogen-activated protein kinase cascade in the CA1/CA2 subfield of the dorsal hippocampus is essential for long-term spatial memory.

1 reference

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18 August 2018

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1 reference

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18 August 2018

Conditioned and unconditional components of post-shock freezing.

1 reference

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18 August 2018

Inhibition of cyclic AMP phosphodiesterase (PDE4) reverses memory deficits associated with NMDA receptor antagonism

1 reference

https://pubmed.ncbi.nlm.nih.gov/18230676

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of specific phosphodiesterase isoforms by constitutive activation of the cAMP pathway in autonomous thyroid adenomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/18230676

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential changes in the expression of cyclic nucleotide phosphodiesterase isoforms in rat brains by chronic treatment with electroconvulsive shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/18230676

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1101/LM.723708

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18230676%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18230676%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18230676%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

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