(Q41861464)

13 October 2017

Grp94, the endoplasmic reticulum Hsp90, has a similar solution conformation to cytosolic Hsp90 in the absence of nucleotide (English)

1 reference

13 October 2017

endoplasmic reticulum

0 references

author name string

Kristin A Krukenberg

1

1 reference

13 October 2017

Ulrike M K Böttcher

2

1 reference

13 October 2017

Daniel R Southworth

3

1 reference

13 October 2017

David A Agard

4

1 reference

13 October 2017

language of work or name

1 reference

1 September 2009

1 reference

13 October 2017

1 reference

13 October 2017

18

1 reference

13 October 2017

9

1 reference

13 October 2017

1815-1827

1 reference

New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential.

13 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Spatially and kinetically resolved changes in the conformational dynamics of the Hsp90 chaperone machine

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Phase II trial of 17-allylamino-17-demethoxygeldanamycin in patients with metastatic melanoma.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Species-dependent ensembles of conserved conformational states define the Hsp90 chaperone ATPase cycle

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Intra- and intermonomer interactions are required to synergistically facilitate ATP hydrolysis in Hsp90.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Multiple conformations of E. coli Hsp90 in solution: insights into the conformational dynamics of Hsp90.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Apo-Hsp90 coexists in two open conformational states in solution.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Structures of GRP94-nucleotide complexes reveal mechanistic differences between the hsp90 chaperones

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Hsp90--from signal transduction to cell transformation.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

The peptide-binding activity of GRP94 is regulated by calcium.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Structure and mechanism of the Hsp90 molecular chaperone machinery

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Effect of hsp70 chaperone on the folding and misfolding of polypeptides modeling an elongating protein chain

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Pathways of chaperone-mediated protein folding in the cytosol

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Ligand-induced conformational shift in the N-terminal domain of GRP94, an Hsp90 chaperone

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Negative staining and image classification — powerful tools in modern electron microscopy

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Development of Purine-Scaffold Small Molecule Inhibitors of Hsp90

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Stimulation of the weak ATPase activity of human hsp90 by a client protein

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Hsp90: chaperoning signal transduction

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Determination of domain structure of proteins from X-ray solution scattering

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Endoplasmic reticulum chaperone GRP94 subunit assembly is regulated through a defined oligomerization domain.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Mechanism of GroEL action: Productive release of polypeptide from a sequestered position under groes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

The large conformational changes of Hsp90 are only weakly coupled to ATP hydrolysis

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

The ATPase cycle of the endoplasmic chaperone Grp94.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Independent ATPase activity of Hsp90 subunits creates a flexible assembly platform

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777357

Four intracisternal calcium-binding glycoproteins from rat liver microsomes with high affinity for calcium. No indication for calsequestrin-like proteins in inositol 1,4,5-trisphosphate-sensitive calcium sequestering rat liver vesicles

18 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19554567

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Sequential interaction of the chaperones BiP and GRP94 with immunoglobulin chains in the endoplasmic reticulum

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19554567

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identification of a set of calcium-binding proteins in reticuloplasm, the luminal content of the endoplasmic reticulum

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19554567

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/PRO.191

1 reference

13 October 2017

1 reference

13 October 2017

PubMed publication ID

19554567

1 reference