(Q41875935)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18668033%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

title

Brain drug-metabolizing cytochrome P450 enzymes are active in vivo, demonstrated by mechanism-based enzyme inhibition (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18668033%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18668033%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

author name string

Sharon Miksys

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18668033%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

language of work or name

English

0 references

publication date

30 July 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18668033%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

published in

Neuropsychopharmacology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18668033%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

volume

34

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18668033%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18668033%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

page(s)

634-640

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18668033%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/npp.2008.110

11 January 2020

exact match

0 references

cites work

CYP2D6 polymorphism: implications for antipsychotic drug response, schizophrenia and personality traits

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Expression and function of cytochrome p450 in brain drug metabolism

5 June 2018

1 reference

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Mammalian cytochromes P450--importance of tissue specificity.

5 June 2018

1 reference

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CYP2C19 polymorphism affects personality traits of Japanese females.

5 June 2018

1 reference

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Nicotine induces brain CYP enzymes: relevance to Parkinson's disease

5 June 2018

1 reference

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Potential role of cerebral cytochrome P450 in clinical pharmacokinetics: modulation by endogenous compounds

5 June 2018

1 reference

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The unique regulation of brain cytochrome P450 2 (CYP2) family enzymes by drugs and genetics.

5 June 2018

1 reference

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Smoking and Parkinson's disease: systematic review of prospective studies

5 June 2018

1 reference

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Pharmacogenetic determinants of interindividual variability in bupropion hydroxylation by cytochrome P450 2B6 in human liver microsomes

5 June 2018

1 reference

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5-Hydroxytryptamine is biotransformed by CYP2C9, 2C19 and 2B6 to hydroxylamine, which is converted into nitric oxide

5 June 2018

1 reference

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Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry

5 June 2018

1 reference

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Drug-metabolizing cytochrome P450s in the brain.

5 June 2018

1 reference

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Regional and cellular induction of nicotine-metabolizing CYP2B1 in rat brain by chronic nicotine treatment

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

Novel metabolic pathway of estrone and 17beta-estradiol catalyzed by cytochrome P-450.

5 June 2018

1 reference

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Human CYP2B6: expression, inducibility and catalytic activities

5 June 2018

1 reference

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The role of CYP2B6 in human xenobiotic metabolism

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968-1998)--a review

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

Biphasic kinetics of imipramine N-oxidation in rat brain microsomes.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

Dopamine formation from tyramine by CYP2D6.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

New proteins in the rat CYP2B subfamily: presence in liver microsomes of the constitutive CYP2B3 protein and the phenobarbital-inducible protein product of alternatively spliced CYP2B2 mRNA

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

Progress in psychiatry (1)

5 June 2018

1 reference

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Phenobarbital-induced rat liver cytochrome P-450. Purification and characterization of two closely related isozymic forms

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

Activation and degradation of the phosphorothionate insecticides parathion and EPN by rat brain

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

Cytochrome P450 isozymes catalyzing 4-hydroxylation of parkinsonism-related compound 1,2,3,4-tetrahydroisoquinoline in rat liver microsomes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

Cytochrome P-450 in the brain. Potential evolutionary and therapeutic relevance of localization of drug-metabolizing enzymes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

Enzymatic and chemical demethylenation of (methylenedioxy)amphetamine and (methylenedioxy)methamphetamine by rat brain microsomes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

CYP 2E1 mutant mice are resistant to DDC-induced enhancement of MPTP toxicity.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

Association between cytochrome P450 (CYP) 2C19 polymorphisms and harm avoidance in Japanese.

18 August 2018

1 reference

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The effect of cigarette smoking on the hypnotic efficacy of propofol.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

Cytosolic persistence of mouse brain CYP1A1 in chronic heme deficiency

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

Effect of genetic polymorphism on the metabolism of endogenous neuroactive substances, progesterone and p-tyramine, catalyzed by CYP2D6.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

Involvement of cytochrome P450 2E1 in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

Further evidence that interactions between CYP2D6 and pesticide exposure increase risk for Parkinson's disease

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

Cytochrome P450 CYP1A1 accumulates in the cytosol of kidney and brain and is activated by heme

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

Toxicological consequences of differential regulation of cytochrome p450 isoforms in rat brain regions by phenobarbital

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

Induction of CYP2B1/2 and nicotine metabolism by ethanol in rat liver but not rat brain

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

Progesterone oxidation by cytochrome P450 2D isoforms in the brain

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

The effect of smoking on postoperative nausea and vomiting.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

Characterization of cytochrome P-450 2D1 activity in rat brain: high-affinity kinetics for dextromethorphan.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5258186

Cigarette smoking and Parkinson's disease: A case-control study in a population characterized by a high prevalence of pesticide exposure

18 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNPP.2008.110

Relationship between personality and debrisoquine hydroxylation capacity

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNPP.2008.110

Cytochrome P -450 activities in human and rat brain microsomes

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNPP.2008.110

Association of CYP2D6 Genotypes and Personality Traits in Healthy Individuals

21 January 2018

1 reference

12 December 2020

Mechanistic studies of cytochrome P450 2B1 inactivation by xanthates

1 reference

12 December 2020

1 reference

12 December 2020

Mechanism-based inactivation of cytochrome P450 2B1 by 8-methoxypsoralen and several other furanocoumarins

1 reference

12 December 2020

Selective mechanism-based inactivation of cytochromes P-450 2B1 and P-450 2B6 by a series of xanthates

1 reference

12 December 2020

Debrisoquine hydroxylation polymorphism and personality

1 reference

12 December 2020

The 1'-hydroxylation of Rac-bufuralol by rat brain microsomes

1 reference

12 December 2020

Identifiers

DOI

10.1038/NPP.2008.110

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18668033%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

11 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18668033%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

1 reference