(Q35859052)

10 August 2017

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title

Potential role of cerebral cytochrome P450 in clinical pharmacokinetics: modulation by endogenous compounds (English)

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10 August 2017

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Guillermo Gervasini

1

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10 August 2017

Juan Antonio Carrillo

series ordinal

2

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10 August 2017

Julio Benitez

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3

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10 August 2017

1 January 2004

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Clinical Pharmacokinetics

10 August 2017

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10 August 2017

43

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10 August 2017

11

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10 August 2017

693-706

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https://scigraph.springernature.com/pub.10.2165/00003088-200443110-00001

10 August 2017

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cites work

Relationship between personality and debrisoquine hydroxylation capacity

1 reference

12 December 2020

Drug interactions and the cytochrome P450 system. The role of cytochrome P450 1A2.

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12 December 2020

Purification of multiple forms of cytochrome P450 from a human brain and reconstitution of catalytic activities.

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12 December 2020

Clinical implications of antidepressant pharmacokinetics and pharmacogenetics

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12 December 2020

The genetic determinants of the CYP3A5 polymorphism

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12 December 2020

Modulation of CYP1A2 enzyme activity by indoleamines: inhibition by serotonin and tryptamine.

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12 December 2020

Cytochrome P450 in the brain; a review.

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12 December 2020

Co-localization of P450 enzymes in the rat substantia nigra with tyrosine hydroxylase

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12 December 2020

Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes

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12 December 2020

Brain cytochrome P450 and testosterone metabolism by rat brain subcellular fractions: presence of cytochrome P450 3A immunoreactive protein in rat brain mitochondria.

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12 December 2020

Fluvoxamine is a potent inhibitor of cytochrome P4501A2

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12 December 2020

Identification of the human cytochromes P450 responsible for the in vitro formation of the major oxidative metabolites of the antipsychotic agent olanzapine.

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12 December 2020

Differential metabolism of alprazolam by liver and brain cytochrome (P4503A) to pharmacologically active metabolite

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12 December 2020

Human cytochromes mediating N-demethylation of fluoxetine in vitro

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12 December 2020

Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6.

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12 December 2020

Expression and distribution of CYP2C enzymes in rat basal ganglia.

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12 December 2020

MGMT- and P450 3A-inhibitors do not sensitize glioblastoma cell cultures against nitrosoureas

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12 December 2020

Regional distribution and expression modulation of cytochrome P-450 and epoxide hydrolase mRNAs in the rat brain

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12 December 2020

The predictive value of MDR1, CYP2C9, and CYP2C19 polymorphisms for phenytoin plasma levels

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12 December 2020

Cytochrome P-450 and NADPH cytochrome C reductase in rat brain: Formation of catechols and reactive catechol metabolites

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12 December 2020

Genetic polymorphisms in Parkinson's disease.

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12 December 2020

P450 enzymes and Parkinson's disease: the story so far.

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12 December 2020

Polymorphic O-demethylation of codeine

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12 December 2020

MPTP, the neurotoxin inducing Parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation.

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12 December 2020

Tissue distribution of bufuralol hydroxylase activity in Sprague-Dawley rats

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12 December 2020

Activation of cytochrome P450 gene expression in the rat brain by phenobarbital-like inducers

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12 December 2020

Cerebrospinal fluid concentrations of caffeine following oral drug administration: correlation with salivary and plasma concentrations

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12 December 2020

Genetic polymorphism in the 5'-flanking region of human CYP1A2 gene: effect on the CYP1A2 inducibility in humans

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12 December 2020

In search of endogenous CYP2D6 substrates

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12 December 2020

Functional hyperemia in the brain: hypothesis for astrocyte-derived vasodilator metabolites

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12 December 2020

Biochemistry and molecular biology of the human CYP2C subfamily

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12 December 2020

Parkinson's disease, but not Alzheimer's disease, Lewy body variant associated with mutant alleles at cytochrome P450 gene

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12 December 2020

Identification of cytochromes P450 1A2, 2A1, 2C7, 2E1 in rat glioma C6 cell line by RT-PCR and specific restriction enzyme digestion

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12 December 2020

Immunological comparison of hepatic and extrahepatic cytochromes P-450

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12 December 2020

Constitutive expression and localization of the major drug metabolizing enzyme, cytochrome P4502D in human brain

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12 December 2020

Regional distribution of cytochrome P450 2D1 in the rat central nervous system.

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12 December 2020

Subcellular localization of cytochrome P450, and activities of several enzymes responsible for drug metabolism in the human brain.

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12 December 2020

Inhibition of cytochrome P450 2C9 activity in vitro by 5-hydroxytryptamine and adrenaline

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12 December 2020

Codeine increases pain thresholds to copper vapor laser stimuli in extensive but not poor metabolizers of sparteine.

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12 December 2020

Tryptamine: a possible endogenous substrate for CYP2D6.

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12 December 2020

Biochemical assessment of preoperative stress: a study with diazepam and measurement of monoamine metabolites and catecholamines in cerebrospinal fluid and plasma

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12 December 2020

Insights into gender bias: rat cytochrome P450 3A9

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12 December 2020

CYP1A2 activity, gender and smoking, as variables influencing the toxicity of caffeine

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12 December 2020

Regional distribution of individual forms of cytochrome P450 mRNA in normal adult human brain

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12 December 2020

Modulation of midazolam 1-hydroxylation activity in vitro by neurotransmitters and precursors.

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12 December 2020

Treatment of codeine dependence with inhibitors of cytochrome P450 2D6

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12 December 2020

Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid

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12 December 2020

Urinary Metabolites in Parkinson's Disease

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12 December 2020

Differences in hypothalamic serotonin between estrous phases and gender: an in vivo microdialysis study.

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12 December 2020

Oxidative polymorphism of debrisoquine in Parkinson's disease

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12 December 2020

The relative contribution of monoamine oxidase and cytochrome p450 isozymes to the metabolic deamination of the trace amine tryptamine.

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12 December 2020

Regulation of dopamine release by impulse flow and by autoreceptors as studied by in vivo voltammetry in the rat striatum.

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12 December 2020

Cytochromes P450 mediating the N-demethylation of amitriptyline

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12 December 2020

Selected ion monitoring analysis of monoamine metabolites in cerebrospinal fluid. Application to the study of in vivo effects of alpha 2-antagonists

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12 December 2020

Effect of ethanol on cytochrome P450 in the rat brain

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12 December 2020

Rate of cognitive decline in Alzheimer's disease is not affected by the alpha-1-antichymotrypsin A allele or the CYP2D6 B mutant.

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12 December 2020

P450-expression in brain tumors

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12 December 2020

Expression and localisation of CYP2D enzymes in rat basal ganglia

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12 December 2020

Cytochrome P450 in the brain: 2B or not 2B.

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12 December 2020

Rat brain cytochromes P-450: catalytic, immunochemical properties and inducibility of multiple forms

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12 December 2020

Concurrent monitoring of central carbamazepine and transmitter amine metabolism and motor activity in individual unrestrained rats using repetitive withdrawal of cerebrospinal fluid.

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12 December 2020

Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes

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12 December 2020

Regional and cellular distribution of CYP2D subfamily members in rat brain.

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12 December 2020

Identification of the major cytochrome P450s of subfamily 2C that are expressed in brain of female rats and in olfactory lobes of ethanol treated male rats.

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12 December 2020

Central tryptamine turnover in depression, schizophrenia, and anorexia: measurement of indoleacetic acid in cerebrospinal fluid.

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12 December 2020

Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4.

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12 December 2020

Cytochrome P-450 in the brain. Potential evolutionary and therapeutic relevance of localization of drug-metabolizing enzymes

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12 December 2020

Inhibition of cytochrome P450 2D6 modifies codeine abuse liability

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12 December 2020

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines

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12 December 2020

Experimental protocol for clinical analysis of cerebrospinal fluid by high resolution proton magnetic resonance spectroscopy.

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12 December 2020

CYP2D6 polymorphisms in Alzheimer's disease, with and without extrapyramidal signs, showing no apolipoprotein E epsilon 4 effect modification.

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12 December 2020

Induction of CYP2B1/2 and nicotine metabolism by ethanol in rat liver but not rat brain

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12 December 2020

Effects of CYP2C19 genotype and CYP2C9 on fluoxetine N-demethylation in human liver microsomes

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12 December 2020

The human hepatic cytochromes P450 involved in drug metabolism

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12 December 2020

Modulation of cytochrome P450 by inflammation in astrocytes.

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12 December 2020

Characterization of cytochrome P-450-dependent aminopyrine N-demethylase in rat brain: comparison with hepatic aminopyrine N-demethylation

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12 December 2020

Drug-metabolizing cytochrome P450s in the brain.

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12 December 2020

Regional distribution of ethanol-inducible cytochrome P450 IIE1 in the rat central nervous system.

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12 December 2020

Neuronal cytochrome P450IID1 (debrisoquine/sparteine-type): potent inhibition of activity by (-)-cocaine and nucleotide sequence identity to human hepatic P450 gene CYP2D6

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12 December 2020

Regional and cellular expression of CYP2D6 in human brain: higher levels in alcoholics.

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12 December 2020

No association between familial Alzheimer disease and cytochrome P450 polymorphisms.

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12 December 2020

Cytochrome P450-dependent metabolism of l-deprenyl in monkey (Cercopithecus aethiops) and C57BL/6 mouse brain microsomal preparations.

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12 December 2020

Basic characteristics of noradrenaline release in the hippocampus of intact and 6-hydroxydopamine-lesioned rats as studied by in vivo microdialysis.

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12 December 2020

Multiple forms of cytochrome P450 and associated monooxygenase activities in human brain mitochondria.

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12 December 2020

Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in human beings

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12 December 2020

Distribution and induction of cytochrome P450 1A1 and 1A2 in rat brain.

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12 December 2020

Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalyzed by human liver microsomes

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12 December 2020

[3H]GBR-12935 binding to cytochrome P450 in the human brain.

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12 December 2020

Ecogenetics of Parkinson's disease: 4-hydroxylation of debrisoquine

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12 December 2020

CYP2D6*4 polymorphism is not associated with Parkinson's disease and has no protective role against Alzheimer's disease in the Korean population.

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12 December 2020

CYP2D6 polymorphism in Parkinson's disease: The Rotterdam study

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12 December 2020

Cytochrome P450 monooxygenases and interactions of psychotropic drugs: a five-year update

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12 December 2020

Debrisoquine hydroxylation polymorphism and personality

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12 December 2020

Toxicological consequences of differential regulation of cytochrome p450 isoforms in rat brain regions by phenobarbital

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12 December 2020

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

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12 December 2020

Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos.

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12 December 2020

Tryptamine: a metabolite of tryptophan implicated in various neuropsychiatric disorders

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12 December 2020

cDNA cloning of a novel CYP3A from rat brain

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12 December 2020

Quantitation of Morphine, Morphine-3-Glucuronide, and Morphine-6-Glucuronide in Plasma and Cerebrospinal Fluid Using Solid-Phase Extraction and High-Performance Liquid Chromatography with Electrochemical Detection

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12 December 2020

The 1'-hydroxylation of Rac-bufuralol by rat brain microsomes

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12 December 2020

Pharmacogenetics of tolbutamide metabolism in humans

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12 December 2020

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

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12 December 2020

Cytochrome P450 (P450) isoenzyme specific dealkylation of alkoxyresorufins in rat brain microsomes

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12 December 2020

Disposition of fluvoxamine in humans is determined by the polymorphic CYP2D6 and also by the CYP1A2 activity

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12 December 2020

Immunohistochemical localization of cytochrome P450 enzymes 2C and 4A in the normal rat brain.

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12 December 2020

cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450

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12 December 2020

Polymorphic formation of morphine from codeine in poor and extensive metabolizers of dextromethorphan: relationship to the presence of immunoidentified cytochrome P-450IID1.

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12 December 2020

Subcellular distribution of cytochrome P-450 in the brain.

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12 December 2020

Repetitive measurement of monoamine metabolite levels in cerebrospinal fluid of conscious rats: Effects of reserpine and haloperidol

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12 December 2020

Clinically significant interactions of psychotropic agents with antipsychotic drugs

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12 December 2020

Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain

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12 December 2020

The CYP2D6B allele is associated with a milder synaptic pathology in Alzheimer's disease

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12 December 2020

Caffeine metabolism in a healthy Spanish population: N-acetylator phenotype and oxidation pathways

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12 December 2020

Testosterone metabolism in rat brain is differentially enhanced by phenytoin-inducible cytochrome P450 isoforms.

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12 December 2020

Effect of subarachnoid hemorrhage on intracranial pulse waves in cats

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12 December 2020

Role of the smoking-induced cytochrome P450 (CYP)1A2 and polymorphic CYP2D6 in steady-state concentration of olanzapine

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12 December 2020

Regional and cellular induction of nicotine-metabolizing CYP2B1 in rat brain by chronic nicotine treatment

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12 December 2020

Cloning and tissue distribution of a novel human cytochrome p450 of the CYP3A subfamily, CYP3A43.

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12 December 2020

Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization.

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12 December 2020

Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors

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12 December 2020

Xenobiotic metabolism in human brain--presence of cytochrome P-450 and associated mono-oxygenases.

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12 December 2020

Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test

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12 December 2020

Polymorphic hydroxylation of Debrisoquine in man.

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12 December 2020

Debrisoquine oxidation phenotype in psychiatric patients.

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12 December 2020

Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data.

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12 December 2020

Genetically variable metabolism of antidepressants and neuroleptic drugs in man.

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12 December 2020

Functional significance of a C-->A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine

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12 December 2020

Anatomical distribution of NADPH-cytochrome P450 reductase and cytochrome P4502D forms in rat brain: effects of xenobiotics and sex steroids.

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12 December 2020

Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications

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12 December 2020

The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature

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12 December 2020

Regulation of expression of cytochrome P-450 2D mRNA in rat brain with steroid hormones.

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12 December 2020

Association between the oxidative polymorphism and early onset of Parkinson's disease

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12 December 2020

Genetic polymorphism of CYP2D6 in the Japanese population

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12 December 2020

Identification and functional characterization of a new CYP2C9 variant (CYP2C9*5) expressed among African Americans

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12 December 2020

Cerebrospinal fluid indoleacetic acid in autistic subjects.

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12 December 2020

Cytochromes P450 in brain: function and significance

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12 December 2020

Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase

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12 December 2020

Induction of brain cytochrome P-450IIE1 by chronic ethanol treatment

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12 December 2020

Dopamine formation from tyramine by CYP2D6.

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12 December 2020

Characterization of cytochrome P-450 2D1 activity in rat brain: high-affinity kinetics for dextromethorphan.

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12 December 2020

Monoamine concentrations in cerebrospinal fluid of fetal and newborn sheep.

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12 December 2020

Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease

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12 December 2020

CYP2D6 is associated with Parkinson's disease but not with dementia with Lewy Bodies or Alzheimer's disease.

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12 December 2020

Ritonavir and dexamethasone induce expression of CYP3A and P-glycoprotein in rats

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12 December 2020

Regulation of cytochrome P450 in the central nervous system

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12 December 2020

Microsomal cytochrome P450 in human brain regions

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12 December 2020

Are poor metabolisers of sparteine/debrisoquine less pain tolerant than extensive metabolisers?

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12 December 2020

Evaluation of caffeine as a test drug for CYP1A2, NAT2 and CYP2E1 phenotyping in man by in vivo versus in vitro correlations.

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12 December 2020

Constitutive and inducible levels of CYP1A1 and CYP1A2 in rat cerebral cortex and cerebellum

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12 December 2020

Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes

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12 December 2020

Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs

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12 December 2020

Cytochrome P -450 activities in human and rat brain microsomes

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12 December 2020

Regional distribution of cytochrome P-450 in the rat brain: spectral quantitation and contribution of P-450b,e, and P-450c,d.

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12 December 2020

The CYP2D6B mutant allele is overrepresented in the Lewy body variant of Alzheimer's disease.

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12 December 2020

Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform

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12 December 2020

Cloning, sequencing, heterologous expression, and characterization of murine cytochrome P450 3a25*(Cyp3a25), a testosterone 6beta-hydroxylase

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12 December 2020

Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation

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12 December 2020

Morphine formation from codeine in rat brain: a possible mechanism of codeine analgesia.

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12 December 2020

Parkinson's disease, CYP2D6 polymorphism, and age

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12 December 2020

Mutant debrisoquine hydroxylation genes in Parkinson's disease

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12 December 2020

Aromatic Amines and Parkinson's Disease

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12 December 2020

Ethosuximide in tears, saliva, and cerebrospinal fluid

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12 December 2020

Regiospecific expression of cytochrome P-450s and microsomal epoxide hydrolase in human brain tissue

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12 December 2020

Inhibition of cytochrome P450 2E1 induces an increase in extracellular dopamine in rat substantia nigra: a new metabolic pathway?

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12 December 2020

Hepatic and central nervous system cytochrome P450 are down-regulated during lipopolysaccharide-evoked localized inflammation in brain.

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12 December 2020

10.2165/00003088-200443110-00001

Identifiers

DOI

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Dimensions Publication ID

10 August 2017

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