(Q41876554)

English

Augmented intrinsic activity of Factor VIIa by replacement of residues 305, 314, 337 and 374: evidence of two unique mutational mechanisms of activity enhancement

scientific article published on April 2004

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Augmented intrinsic activity of Factor VIIa by replacement of residues 305, 314, 337 and 374: evidence of two unique mutational mechanisms of activity enhancement (English)

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

author name string

Egon Persson

1

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Helle Bak

2

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Anette Østergaard

3

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Ole H Olsen

4

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

language of work or name

0 references

publication date

1 April 2004

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Biochemical Journal

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

379

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Pt 2

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

497-503

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Factor VII mutant V154G models a zymogen-like form of factor VIIa.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

5 June 2018

Platelets and thrombin generation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

5 June 2018

Crystal structures of uninhibited factor VIIa link its cofactor and substrate-assisted activation to specific interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

5 June 2018

Rational design of coagulation factor VIIa variants with substantially increased intrinsic activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

5 June 2018

The factor VII zymogen structure reveals reregistration of beta strands during activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

5 June 2018

Substitution of valine for leucine 305 in factor VIIa increases the intrinsic enzymatic activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

5 June 2018

Binding of Zn2+ to a Ca2+ loop allosterically attenuates the activity of factor VIIa and reduces its affinity for tissue factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

5 June 2018

Peptide exosite inhibitors of factor VIIa as anticoagulants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

5 June 2018

Crystal structure of active site-inhibited human coagulation factor VIIa (des-Gla)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

5 June 2018

Structure of human factor VIIa and its implications for the triggering of blood coagulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

5 June 2018

Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

5 June 2018

Incorporation of an active site inhibitor in factor VIIa alters the affinity for tissue factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

5 June 2018

Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

5 June 2018

Structural changes in factor VIIa induced by Ca2+ and tissue factor studied using circular dichroism spectroscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

5 June 2018

Site-directed mutagenesis but not gamma-carboxylation of Glu-35 in factor VIIa affects the association with tissue factor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

5 June 2018

The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

5 June 2018

Activation of human factor VII in the initiation of tissue factor-dependent coagulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

5 June 2018

Amino acid sequence and posttranslational modifications of human factor VIIa from plasma and transfected baby hamster kidney cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

5 June 2018

Activation of factor VII bound to tissue factor: a key early step in the tissue factor pathway of blood coagulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

5 June 2018

Initiation of the extrinsic pathway of blood coagulation: evidence for the tissue factor dependent autoactivation of human coagulation factor VII.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

5 June 2018

The coagulation cascade: initiation, maintenance, and regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

5 June 2018

Tissue factor-dependent autoactivation of human blood coagulation factor VII.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

5 June 2018

Allosteric regulation of the cofactor-dependent serine protease coagulation factor VIIa.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

18 August 2018

Assignment of molecular properties of a superactive coagulation factor VIIa variant to individual amino acid changes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

18 August 2018

Role of zymogenicity-determining residues of coagulation factor VII/VIIa in cofactor interaction and macromolecular substrate recognition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

18 August 2018

Factor VIIa modified in the 170 loop shows enhanced catalytic activity but does not change the zymogen-like property

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

18 August 2018

Substitution of aspartic acid for methionine-306 in factor VIIa abolishes the allosteric linkage between the active site and the binding interface with tissue factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

18 August 2018

Residue Met(156) contributes to the labile enzyme conformation of coagulation factor VIIa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1224069

18 August 2018

Role of residue Phe225 in the cofactor-mediated, allosteric regulation of the serine protease coagulation factor VIIa

1 reference

https://pubmed.ncbi.nlm.nih.gov/14686879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Factor VII autoactivation proceeds via interaction of distinct protease-cofactor and zymogen-cofactor complexes. Implications of a two-dimensional enzyme kinetic mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/14686879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of the gamma-carboxyglutamic acid-rich domain and hydrophobic stack of factor VIIa on tissue factor binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/14686879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The 99 and 170 loop-modified factor VIIa mutants show enhanced catalytic activity without tissue factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/14686879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of regions of bovine factor VII essential for binding to tissue factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/14686879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ20031596

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

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