(Q41877476)

13 October 2017

The anti-cancer drug 5-fluorouracil is metabolized by the isolated perfused rat liver and in rats into highly toxic fluoroacetate (English)

1 reference

13 October 2017

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Arellano M

1

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13 October 2017

Malet-Martino M

series ordinal

2

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13 October 2017

Martino R

series ordinal

3

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13 October 2017

Gires P

series ordinal

4

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13 October 2017

language of work or name

English

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publication date

1 January 1998

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British Journal of Cancer

13 October 2017

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13 October 2017

77

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13 October 2017

1

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13 October 2017

79-86

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https://scigraph.springernature.com/pub.10.1038/bjc.1998.12

13 October 2017

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cites work

5-Ethynyluracil (GW776): effects on the formation of the toxic catabolites of 5-fluorouracil, fluoroacetate and fluorohydroxypropionic acid in the isolated perfused rat liver model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151255

The syndrome of 5-fluorouracil cardiotoxicity. An elusive cardiopathy

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151255

5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151255

Fluorouracil cardiotoxicity

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151255

Fluorinated substrate analogs: routes of metabolism and selective toxicity.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151255

Biochemical basis for fluorouracil neurotoxicity. The role of Krebs cycle inhibition by fluoroacetate.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151255

Metabolites of 5-fluorouracil in plasma and urine, as monitored by 19F nuclear magnetic resonance spectroscopy, for patients receiving chemotherapy with or without methotrexate pretreatment

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151255

Beta-amino acids: mammalian metabolism and utility as alpha-amino acid analogues

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151255

19F nuclear magnetic resonance analysis of the carbamate reaction of alpha-fluoro-beta-alanine (FBAL), the major catabolite of fluoropyrimidines. Application to FBAL carbamate determination in body fluids of patients treated with 5'-deoxy-5-fluorour

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151255

Continuous ambulatory ECG monitoring during fluorouracil therapy: a prospective study

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151255

5-Fluorouracil neurotoxicity

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151255

Purification, characterization and inhibition of D-3-aminoisobutyrate aminotransferase from the rat liver

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151255

Experimental neurotoxicity of 5-fluorouracil and its derivatives is due to poisoning by the monofluorinated organic metabolites, monofluoroacetic acid and alpha-fluoro-beta-alanine

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151255

Acute cardiac toxicity of 5-fluorouracil: pharmacokinetic correlation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151255

Cardiotoxicity of commercial 5-fluorouracil vials stems from the alkaline hydrolysis of this drug

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151255

Magnetic resonance spectroscopy: a powerful tool for drug metabolism studies

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151255

Cardiotoxicity of high-dose continuous infusion fluorouracil: a prospective clinical study

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151255

Pharmacokinetics and tissue distribution of 2-fluoro-beta-alanine in rats. Potential relevance to toxicity pattern of 5-fluorouracil.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151255

Studies on fluorinated pyrimidines. IX. The degradation of 5-fluorouracil-6-C14

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151255

Enzymatic elimination of fluoride from alpha-fluoro-beta-alanine.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2151255

Streptomyces beta-alanine:alpha-ketoglutarate aminotransferase, a novel omega-amino acid transaminase. Purification, crystallization, and enzymologic properties

18 August 2018

1 reference

12 December 2020

Serum citrate as a peripheral indicator of fluoroacetate and fluorocitrate toxicity in rats and dogs

1 reference

12 December 2020

Gas chromatographic determination of sodium monofluoroacetate in water by derivatization with dicyclohexylcarbodiimide

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12 December 2020

Determination of fluoroacetate in biological matrixes as the dodecyl ester

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12 December 2020

Inhibition of D-3-aminoisobutyrate-pyruvate aminotransferase by 5-fluorouracil and alpha-fluoro-beta-alanine

1 reference

12 December 2020

Fluoroacetate-mediated toxicity of fluorinated ethanes

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12 December 2020

5-Fluorouracil metabolite patterns in viable and necrotic tumor areas of murine colon carcinoma determined by 19F NMR spectroscopy

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12 December 2020

The catabolism of C14-labeled beta-alanine in the intact rat

1 reference

12 December 2020

CEREBELLAR ATAXIA ASSOCIATED WITH FLUORINATED PYRIMIDINE THERAPY

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12 December 2020

THE PHOTOCHEMISTRY OF 5-FLUOROURACIL

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12 December 2020

High pressure liquid chromatographic determination of sodium fluoroacetate (compound 1080) in canine gastric content

1 reference

12 December 2020

Modified gas-liquid chromatographic method for determination of compound 1080 (sodium fluoroacetate)

1 reference

12 December 2020

Liquid chromatographic determination of sodium fluoroacetate (Compound 1080) in meat baits and formulations

1 reference

12 December 2020

Release of fluoride ion from 5'-deoxy-5-fluorouridine, an antineoplastic fluoropyrimidine, in humans

1 reference

12 December 2020

Identifiers

DOI

10.1038/BJC.1998.12

1 reference

13 October 2017

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13 October 2017

PubMed publication ID

9459149

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