(Q41886449)

English

Modulation of catalytic function by differential plasticity of the active site: case study of Trypanosoma cruzi trans-sialidase and Trypanosoma rangeli sialidase

scientific article published on April 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Modulation of catalytic function by differential plasticity of the active site: case study of Trypanosoma cruzi trans-sialidase and Trypanosoma rangeli sialidase (English)

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Trypanosoma cruzi

0 references

Trypanosoma rangeli

object named as

Trypanosoma rangeli

1 reference

based on heuristic

inferred from title

1

object named as

Ozlem Demir

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Adrian Roitberg

2

object named as

Adrian E Roitberg

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

language of work or name

0 references

publication date

1 April 2009

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

48

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

15

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

3398-3406

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Discovery of drug-like inhibitors of an essential RNA-editing ligase in Trypanosoma brucei

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

5 June 2018

A poke in the eye: inhibiting HIV-1 protease through its flap-recognition pocket

1 reference

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5 June 2018

Rational drug design in parasitology: trans-sialidase as a case study for Chagas disease.

1 reference

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5 June 2018

Solvated ensemble averaging in the calculation of partial atomic charges

1 reference

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5 June 2018

Targeting structural flexibility in HIV-1 protease inhibitor binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

5 June 2018

Comparison of multiple Amber force fields and development of improved protein backbone parameters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

5 June 2018

Toxic side effects of drugs used to treat Chagas' disease (American trypanosomiasis)

1 reference

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5 June 2018

Quantum mechanical study of the nonbonded forces in water-methanol complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

5 June 2018

Development and testing of a general amber force field

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

5 June 2018

The high resolution structures of free and inhibitor-bound Trypanosoma rangeli sialidase and its comparison with T. cruzi trans-sialidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

5 June 2018

The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

5 June 2018

Protein flexibility and drug design: how to hit a moving target.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

5 June 2018

Solvent interactions determine carbohydrate conformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

5 June 2018

Probing molecular function of trypanosomal sialidases: single point mutations can change substrate specificity and increase hydrolytic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

5 June 2018

Accommodating protein flexibility in computational drug design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

5 June 2018

Trans-sialidase from Trypanosoma cruzi catalyzes sialoside hydrolysis with retention of configuration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

5 June 2018

Structural basis of sialyltransferase activity in trypanosomal sialidases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

5 June 2018

Trypanosoma rangeli sialidase: cloning, expression and similarity to T. cruzi trans-sialidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

5 June 2018

Sialic acids as ligands in recognition phenomena.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

5 June 2018

Sialidases: structures, biological significance and therapeutic potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

5 June 2018

VMD: visual molecular dynamics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

5 June 2018

Chagas disease. American trypanosomiasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

5 June 2018

Structural and functional properties of Trypanosoma trans-sialidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

5 June 2018

Chagas' disease: an ecological appraisal with special emphasis on its insect vectors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

5 June 2018

Molecular interactions in protein crystals: solvent accessible surface and stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

5 June 2018

Identification of the gene(s) coding for the trans-sialidase of Trypanosoma cruzi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

5 June 2018

Structural flexibility in proteins: impact of the crystal environment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

18 August 2018

Remarkable loop flexibility in avian influenza N1 and its implications for antiviral drug design.

1 reference

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18 August 2018

Structural and kinetic analysis of two covalent sialosyl-enzyme intermediates on Trypanosoma rangeli sialidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

18 August 2018

A sialidase mutant displaying trans-sialidase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

18 August 2018

Structural insights into the catalytic mechanism of Trypanosoma cruzi trans-sialidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

18 August 2018

Trypanosoma cruzi trans-sialidase operates through a covalent sialyl-enzyme intermediate: tyrosine is the catalytic nucleophile

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

18 August 2018

Sequence of a Trypanosoma rangeli gene closely related to Trypanosoma cruzi trans-sialidase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713503

18 August 2018

Substrate specificity of the Trypanosoma cruzi trans-sialidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19216574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incorporation of sialic acid into Trypanosoma cruzi macromolecules. A proposal for a new metabolic route

1 reference

https://pubmed.ncbi.nlm.nih.gov/19216574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymatic characterization of beta-D-galactoside alpha 2,3-trans-sialidase from Trypanosoma cruzi

1 reference

https://pubmed.ncbi.nlm.nih.gov/19216574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Occurrence ofN-Acetyl- andN-Glycoloylneuraminic Acid inTrypanosoma cruzi

1 reference

https://pubmed.ncbi.nlm.nih.gov/19216574

12 December 2020

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inferred from PubMed ID database lookup

Sialic acids: fascinating sugars in higher animals and man

1 reference

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based on heuristic

inferred from PubMed ID database lookup

The action of Trypanosoma cruzi trans-sialidase on glycolipids and glycoproteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19216574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incorporating protein flexibility in structure-based drug discovery: using HIV-1 protease as a test case

1 reference

https://pubmed.ncbi.nlm.nih.gov/19216574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trypanosoma rangeli sialidase lacks trans-sialidase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19216574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI802230Y

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

ResearchGate publication ID

0 references

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