(Q41904675)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23919277%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

title

Stabilized cyclopropane analogs of the splicing inhibitor FD-895 (English)

1 reference

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6 March 2020

2

1 reference

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6 March 2020

Manoj K Kashyap

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23919277%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

author name string

Reymundo Villa

1

1 reference

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6 March 2020

Deepak Kumar

4

1 reference

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6 March 2020

Thomas J Kipps

5

1 reference

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6 March 2020

Januario E Castro

6

1 reference

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6 March 2020

James J La Clair

7

1 reference

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6 March 2020

Michael D Burkart

8

1 reference

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6 March 2020

language of work or name

English

0 references

publication date

21 August 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23919277%20AND%20SRC:MED&resulttype=core&format=json

Journal of Medicinal Chemistry

6 March 2020

published in

1 reference

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6 March 2020

volume

56

1 reference

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6 March 2020

issue

17

1 reference

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6 March 2020

page(s)

6576-6582

1 reference

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Structure of FD-895 revealed through total synthesis

6 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809018

Enantioselective total synthesis of pladienolide B: a potent spliceosome inhibitor

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809018

Biological validation that SF3b is a target of the antitumor macrolide pladienolide

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809018

Design, synthesis and initial biological evaluation of a novel pladienolide analog scaffold

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809018

Cellular chemosensitivity assays: an overview

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809018

The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809018

Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809018

Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809018

The spliceosome as target for anticancer treatment

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809018

Antitumor compounds based on a natural product consensus pharmacophore

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809018

Synthesis of the macrocyclic core of (-)-pladienolide B.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809018

Natural products to drugs: natural product-derived compounds in clinical trials

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809018

A synthetic entry to pladienolide B and FD-895

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809018

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809018

Chiral allylic and allenic metal reagents for organic synthesis

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809018

Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. III. In vitro and in vivo antitumor activities

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809018

Latent sensitivity to Fas-mediated apoptosis after CD40 ligation may explain activity of CD154 gene therapy in chronic lymphocytic leukemia

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809018

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809018

Enantioselective synthesis of 1,2,3-trisubstituted cyclopropanes using gem-dizinc reagents

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809018

One-pot fermentation of pladienolide D by Streptomyces platensis expressing a heterologous cytochrome P450 gene.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809018

Organization of the biosynthetic gene cluster for the polyketide antitumor macrolide, pladienolide, in Streptomyces platensis Mer-11107.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809018

Splicing factor SF3b as a target of the antitumor natural product pladienolide.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809018

Isolation and characterization of a new 12-membered macrolide FD-895

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3809018

Total synthesis of the potent antitumor macrolides pladienolide B and D

3 November 2018

1 reference

12 December 2020

Connecting the chemical and biological reactivity of epoxides

1 reference

12 December 2020

Synthesis of a pladienolide B analogue with the fully functionalized core structure

1 reference

12 December 2020

Comparison of splicing factor 3b inhibitors in human cells

1 reference

12 December 2020

Stereochemistry of pladienolide B

1 reference

12 December 2020

Identifiers

DOI

10.1021/JM400861T

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23919277%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23919277%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

PubMed publication ID

23919277

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23919277%20AND%20SRC:MED&resulttype=core&format=json