(Q41910374)

English

Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation

scientific article published on 17 February 2009

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scholarly article

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Europe PubMed Central

PMC publication ID

14 October 2017

Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation (English)

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Europe PubMed Central

PMC publication ID

14 October 2017

phosphorylation

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8

object named as

Sagar Lonial

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14 October 2017

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16

object named as

Titus J Boggon

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Europe PubMed Central

PMC publication ID

14 October 2017

author name string

Sumin Kang

1

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14 October 2017

Shannon Elf

2

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14 October 2017

Shaozhong Dong

3

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14 October 2017

Taro Hitosugi

4

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14 October 2017

Katherine Lythgoe

5

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14 October 2017

Ailan Guo

6

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14 October 2017

Hong Ruan

7

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14 October 2017

Hanna J Khoury

9

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14 October 2017

Ifor R Williams

10

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14 October 2017

Benjamin H Lee

11

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14 October 2017

Johannes L Roesel

12

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14 October 2017

Gerard Karsenty

13

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14 October 2017

André Hanauer

14

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14 October 2017

Jack Taunton

15

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14 October 2017

Ting-Lei Gu

17

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14 October 2017

Jing Chen

18

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14 October 2017

language of work or name

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publication date

17 February 2009

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14 October 2017

Molecular and Cellular Biology

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14 October 2017

29

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14 October 2017

8

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14 October 2017

2105-2117

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14 October 2017

Epidermal growth factor stimulates RSK2 activation through activation of the MEK/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663316

5 June 2018

Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663316

5 June 2018

Critical role for Rsk2 in T-lymphocyte activation

1 reference

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5 June 2018

FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663316

5 June 2018

FGFR3 as a therapeutic target of the small molecule inhibitor PKC412 in hematopoietic malignancies

1 reference

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5 June 2018

Podocalyxin is a CD34-related marker of murine hematopoietic stem cells and embryonic erythroid cells

1 reference

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5 June 2018

ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome

1 reference

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5 June 2018

Targeting FGFR3 in multiple myeloma: inhibition of t(4;14)-positive cells by SU5402 and PD173074.

1 reference

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5 June 2018

Preclinical studies of fibroblast growth factor receptor 3 as a therapeutic target in multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663316

5 June 2018

Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663316

5 June 2018

Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663316

5 June 2018

Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663316

5 June 2018

Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663316

5 June 2018

Altered extracellular signal-regulated kinase signaling and glycogen metabolism in skeletal muscle from p90 ribosomal S6 kinase 2 knockout mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663316

5 June 2018

Creation of a stress-activated p90 ribosomal S6 kinase. The carboxyl-terminal tail of the MAPK-activated protein kinases dictates the signal transduction pathway in which they function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663316

5 June 2018

A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663316

5 June 2018

90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663316

5 June 2018

Generation of constitutively active p90 ribosomal S6 kinase in vivo. Implications for the mitogen-activated protein kinase-activated protein kinase family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663316

5 June 2018

Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663316

5 June 2018

The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663316

5 June 2018

Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663316

5 June 2018

Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663316

5 June 2018

Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663316

5 June 2018

Evidence for two catalytically active kinase domains in pp90rsk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663316

5 June 2018

Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I

1 reference

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5 June 2018

Constitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain point mutation found in achondroplasia

1 reference

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5 June 2018

Structural and functional diversity in the FGF receptor multigene family

1 reference

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5 June 2018

Fibroblast growth factor receptor tyrosine kinases: molecular analysis and signal transduction

1 reference

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5 June 2018

SHIP deficiency enhances HSC proliferation and survival but compromises homing and repopulation

1 reference

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18 August 2018

Fusion of ETV6 to fibroblast growth factor receptor 3 in peripheral T-cell lymphoma with a t(4;12)(p16;p13) chromosomal translocation.

1 reference

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18 August 2018

Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas.

1 reference

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18 August 2018

A MAP kinase docking site is required for phosphorylation and activation of p90(rsk)/MAPKAP kinase-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663316

18 August 2018

Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3.

1 reference

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18 August 2018

Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2

1 reference

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3 November 2018

Identifiers

10.1128/MCB.00998-08

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

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