(Q41917505)

English

The molecular basis for species-specific activation of human TRPA1 protein by protons involves poorly conserved residues within transmembrane domains 5 and 6.

scientific article published on 24 May 2013

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

The molecular basis for species-specific activation of human TRPA1 protein by protons involves poorly conserved residues within transmembrane domains 5 and 6. (English)

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

transmembrane protein

0 references

Angelika Lampert

object named as

Angelika Lampert

8

0 references

object named as

Peter W Reeh

7

0 references

Andreas Leffler

10

object named as

Andreas Leffler

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Mirjam J Eberhardt

2

object named as

Mirjam J Eberhardt

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

author name string

Jeanne de la Roche

1

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Alexandra B Klinger

3

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Nancy Stanslowsky

4

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Florian Wegner

5

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Wolfgang Koppert

6

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Michael J M Fischer

9

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

language of work or name

0 references

publication date

24 May 2013

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

288

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

28

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

20280-20292

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Structure and activity of the acid-sensing ion channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Methylglyoxal activates nociceptors through transient receptor potential channel A1 (TRPA1): a possible mechanism of metabolic neuropathies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Species comparison and pharmacological characterization of human, monkey, rat, and mouse TRPA1 channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Activation of TRPA1 by membrane permeable local anesthetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

A TRPA1-dependent mechanism for the pungent sensation of weak acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

The dilated TRPA1 channel pore state is blocked by amiloride and analogues.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Sensing muscle ischemia: coincident detection of acid and ATP via interplay of two ion channels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Irritating channels: the case of TRPA1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

TRPA1 is a component of the nociceptive response to CO2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

The general anesthetic propofol excites nociceptors by activating TRPV1 and TRPA1 rather than GABAA receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Acid-sensing ion channels (ASICs): pharmacology and implication in pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Distinct modulations of human capsaicin receptor by protons and magnesium through different domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

TRPV1 and TRPA1 mediate peripheral nitric oxide-induced nociception in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Cellular and Molecular Mechanisms of Pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Acid-sensitive ion channels and receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

TRPA1: the species difference

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Transient receptor potential channels: targeting pain at the source

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

An efficient one-step site-directed deletion, insertion, single and multiple-site plasmid mutagenesis protocol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Intracellular alkalization causes pain sensation through activation of TRPA1 in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

ASIC3, a sensor of acidic and primary inflammatory pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Molecular determinants of species-specific activation or blockade of TRPA1 channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Uncoupling proton activation of vanilloid receptor TRPV1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

TRP channel activation by reversible covalent modification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Sustained currents through ASIC3 ion channels at the modest pH changes that occur during myocardial ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Characterization of a proton-activated, outwardly rectifying anion channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Acid-induced pain and its modulation in humans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Functional implications of the localization and activity of acid-sensitive channels in rat peripheral nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Molecular physiology of proton transduction in nociceptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Characterisation of a human acid-sensing ion channel (hASIC1a) endogenously expressed in HEK293 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Acid potentiation of the capsaicin receptor determined by a key extracellular site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Impaired nociception and pain sensation in mice lacking the capsaicin receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

The cloned capsaicin receptor integrates multiple pain-producing stimuli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

The capsaicin receptor: a heat-activated ion channel in the pain pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Pain due to experimental acidosis in human skin: evidence for non-adapting nociceptor excitation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Protons selectively induce lasting excitation and sensitization to mechanical stimulation of nociceptors in rat skin, in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

5 June 2018

Modulation of acid-sensing ion channel activity by nitric oxide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

18 August 2018

The role of the capsaicin receptor TRPV1 and acid-sensing ion channels (ASICS) in proton sensitivity of subpopulations of primary nociceptive neurons in rats and mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

18 August 2018

Background potassium channel block and TRPV1 activation contribute to proton depolarization of sensory neurons from humans with neuropathic pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

18 August 2018

A tyrosine residue in TM6 of the Vanilloid Receptor TRPV1 involved in desensitization and calcium permeability of capsaicin-activated currents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

18 August 2018

Lactate enhances the acid-sensing Na+ channel on ischemia-sensing neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711295

18 August 2018

Receptor for protons in the membrane of sensory neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/23709225

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protons activate a cation conductance in a sub-population of rat dorsal root ganglion neurones

1 reference

https://pubmed.ncbi.nlm.nih.gov/23709225

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Responses of adult human dorsal root ganglion neurons in culture to capsaicin and low pH

1 reference

https://pubmed.ncbi.nlm.nih.gov/23709225

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pH response of rat cutaneous nociceptors correlates with extracellular [Na+] and is increased under amiloride

1 reference

https://pubmed.ncbi.nlm.nih.gov/23709225

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M113.479337

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q41917505&oldid=1951974544"