(Q41922145)

14 October 2017

A fully human, allosteric monoclonal antibody that activates the insulin receptor and improves glycemic control (English)

1 reference

14 October 2017

Daniel H Bedinger

3

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author name string

Vinay Bhaskar

1

1 reference

14 October 2017

Ira D Goldfine

2

1 reference

14 October 2017

Angela Lau

4

1 reference

14 October 2017

Hua F Kuan

5

1 reference

14 October 2017

Lisa M Gross

6

1 reference

14 October 2017

Masahisa Handa

7

1 reference

14 October 2017

Betty A Maddux

8

1 reference

14 October 2017

Susan R Watson

9

1 reference

14 October 2017

Shirley Zhu

10

1 reference

14 October 2017

Ajay J Narasimha

11

1 reference

14 October 2017

Raphael Levy

12

1 reference

14 October 2017

Lynn Webster

13

1 reference

14 October 2017

Sujeewa D Wijesuriya

14

1 reference

14 October 2017

Naichi Liu

15

1 reference

14 October 2017

Xiaorong Wu

16

1 reference

14 October 2017

David Chemla-Vogel

17

1 reference

14 October 2017

Catarina Tran

18

1 reference

14 October 2017

Steve R Lee

19

1 reference

14 October 2017

Steve Wong

20

1 reference

14 October 2017

Diane Wilcock

21

1 reference

14 October 2017

Mark L White

22

1 reference

14 October 2017

John A Corbin

23

1 reference

14 October 2017

language of work or name

English

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publication date

8 March 2012

1 reference

14 October 2017

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14 October 2017

61

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14 October 2017

5

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14 October 2017

1263-1271

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

14 October 2017

start time

30 August 2021

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Basal insulin: physiology, pharmacology, and clinical implications

1 reference

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Minireview: IGF, Insulin, and Cancer

5 June 2018

1 reference

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Molecular mechanisms of insulin resistance in type 2 diabetes mellitus

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Long-acting insulin analogs: a review of "real-world" effectiveness in patients with type 2 diabetes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Pharmacological characterization of six trkB antibodies reveals a novel class of functional agents for the study of the BDNF receptor

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Treatment with insulin glargine (Lantus) increases the proliferative potency of the serum of patients with type-1 diabetes: a pilot study on MCF-7 breast cancer cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Glucose binds to the insulin receptor affecting the mutual affinity of insulin and its receptor.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Autoimmune forms of hypoglycemia

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Structural basis of allosteric ligand-receptor interactions in the insulin/relaxin peptide family: implications for other receptor tyrosine kinases and G-protein-coupled receptors

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Insulin analogues display IGF-I-like mitogenic and anti-apoptotic activities in cultured cancer cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

The insulin receptor: a prototype for dimeric, allosteric membrane receptors?

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

High-affinity binding measurements of antibodies to cell-surface-expressed antigens

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Insulin receptor structure and its implications for the IGF-1 receptor

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Role of phosphatidylinositol 3-kinase activation on insulin action and its alteration in diabetic conditions.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Critical nodes in signalling pathways: insights into insulin action

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Insulin signaling and the regulation of glucose transport.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Animal models of diabetes mellitus.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

The metabolic syndrome or the insulin resistance syndrome? Different names, different concepts, and different goals

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

The insulin resistance syndrome

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

CD8+ T cells that express CD4 on their surface (CD4dimCD8bright T cells) recognize an antigen-specific target, are detected in vivo, and can be productively infected by T-tropic HIV.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Noncompetitive antibody neutralization of IL-10 revealed by protein engineering and x-ray crystallography

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Hypoglycemia associated with antibodies to the insulin receptor.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Mechanisms of insulin resistance in human obesity: evidence for receptor and postreceptor defects

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Relationship between plasma glucose and insulin concentration, glucose production, and glucose disposal in normal subjects and patients with non-insulin-dependent diabetes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Banting lecture 1988. Role of insulin resistance in human disease

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Monoclonal antibodies to the insulin receptor as probes of insulin receptor structure and function.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Monoclonal antibodies to the human insulin receptor mimic a spectrum of biological effects in transfected 3T3/HIR fibroblasts without activating receptor kinase

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Anti-insulin receptor antibodies inhibit insulin binding and stimulate glucose metabolism in skeletal muscle.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Diabetic Ketoacidosis: New Concepts and Trends in Pathogenesis and Treatment

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

The Role of Insulin Resistance in the Pathogenesis of Diabetes Mellitus

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Metabolic effects of various antidiabetic and hypolipidaemic agents on a high-fat diet and multiple low-dose streptozocin (MLDS) mouse model of diabetes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Suppression of thyrotropin receptor constitutive activity by a monoclonal antibody with inverse agonist activity.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

scFv single chain antibody variable fragment as inverse agonist of the beta2-adrenergic receptor

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3331746

Proliferative effects of insulin analogues on mammary epithelial cells

18 August 2018

1 reference

12 December 2020

Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study

1 reference

12 December 2020

Monoclonal antibodies as probes of the structure and function of insulin receptors

1 reference

12 December 2020

Clinical course of the syndrome of autoantibodies to the insulin receptor (type B insulin resistance): a 28-year perspective

1 reference

12 December 2020

The role of antireceptor antibodies in stimulating phosphorylation of the insulin receptor

1 reference

12 December 2020

Characterization of the Serum from a Patient with Insulin Resistance and Hypoglycemia: Evidence for Multiple Populations of Insulin Receptor Antibodies with Different Receptor Binding and Insulin-mimicking Activities

1 reference

12 December 2020

Allosteric effects of a monoclonal antibody against thrombin exosite II

1 reference

12 December 2020

Identifiers

DOI

10.2337/DB11-1578

1 reference

14 October 2017

1 reference

14 October 2017

1 reference