(Q41928709)

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The R740S mutation in the V-ATPase a3 subunit increases lysosomal pH, impairs NFATc1 translocation, and decreases in vitro osteoclastogenesis.

scientific article published on January 2013

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22865292%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

The R740S mutation in the V-ATPase a3 subunit increases lysosomal pH, impairs NFATc1 translocation, and decreases in vitro osteoclastogenesis (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22865292%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Valentin Jaumouillé

3

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10 February 2020

6

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10 February 2020

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Irina Voronov

1

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10 February 2020

Noelle Ochotny

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10 February 2020

Celeste Owen

4

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10 February 2020

Morris F Manolson

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10 February 2020

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1 January 2013

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10 February 2020

Journal of Bone and Mineral Research

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10 February 2020

28

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10 February 2020

1

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10 February 2020

108-118

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10 February 2020

Osteoclast differentiation and activation

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

The role of NFAT in osteoclast formation

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

The a3 Isoform of the 100-kDa V-ATPase Subunit Is Highly but Differentially Expressed in Large (≥10 Nuclei) and Small (≤5 Nuclei) Osteoclasts

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

Three subunit a isoforms of mouse vacuolar H(+)-ATPase. Preferential expression of the a3 isoform during osteoclast differentiation

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

Cathepsins in the osteoclast

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification.

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

From lysosomes to the plasma membrane: localization of vacuolar-type H+ -ATPase with the a3 isoform during osteoclast differentiation

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

Infantile malignant, autosomal recessive osteopetrosis: the rich and the poor

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

The V-ATPase a3 subunit mutation R740S is dominant negative and results in osteopetrosis in mice

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

Site-directed mutagenesis of the 100-kDa subunit (Vph1p) of the yeast vacuolar (H+)-ATPase

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

A cation counterflux supports lysosomal acidification

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

A weak base-generating system suitable for selective manipulation of lysosomal pH.

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

Contribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesis

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

Autoamplification of NFATc1 expression determines its essential role in bone homeostasis

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

Transcriptional regulation by calcium, calcineurin, and NFAT

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

The small molecule harmine regulates NFATc1 and Id2 expression in osteoclast progenitor cells

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

Large scale gene expression analysis of osteoclastogenesis in vitro and elucidation of NFAT2 as a key regulator

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

DSCR1 gene expression is dependent on NFATc1 during cardiac valve formation and colocalizes with anomalous organ development in trisomy 16 mice

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

Degradation of regulator of calcineurin 1 (RCAN1) is mediated by both chaperone-mediated autophagy and ubiquitin proteasome pathways

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

A rationale for osteoclast selectivity of inhibiting the lysosomal V-ATPase a3 isoform

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

Inhibitors of the V0 subunit of the vacuolar H+-ATPase prevent segregation of lysosomal- and secretory-pathway proteins

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

Disruption of the Man-6-P targeting pathway in mice impairs osteoclast secretory lysosome biogenesis

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

Interaction of calcineurin with substrates and targeting proteins

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

SnapShot: Ca2+-calcineurin-NFAT signaling

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

NFATc1 affects mouse splenic B cell function by controlling the calcineurin--NFAT signaling network

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

Re-evaluation of antimalarials in treating rheumatic diseases: re-appreciation and insights into new mechanisms of action

1 reference

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21 January 2018

Chloroquine inhibits production of TNF-alpha, IL-1beta and IL-6 from lipopolysaccharide-stimulated human monocytes/macrophages by different modes

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.1727

21 January 2018

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