(Q41934357)

English

Interaction of the 268-282 region of glycoprotein Ibalpha with the heparin-binding site of thrombin inhibits the enzyme activation of factor VIII.

scientific article published on July 2003

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Interaction of the 268-282 region of glycoprotein Ibalpha with the heparin-binding site of thrombin inhibits the enzyme activation of factor VIII. (English)

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

author name string

De Cristofaro R

1

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

De Filippis V

2

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

language of work or name

0 references

publication date

1 July 2003

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Biochemical Journal

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

373

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Pt 2

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

593-601

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Platelets and thrombin generation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

5 June 2018

Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

5 June 2018

Crystal structure of the platelet glycoprotein Ib(alpha) N-terminal domain reveals an unmasking mechanism for receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

5 June 2018

Facile solid-phase synthesis of sulfated tyrosine-containing peptides: total synthesis of human big gastrin-II and cholecystokinin (CCK)-39.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

5 June 2018

New anticoagulant drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

5 June 2018

Platelet-active drugs : the relationships among dose, effectiveness, and side effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

5 June 2018

Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact platelets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

5 June 2018

Crystal structure of the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

5 June 2018

Modeling and functional analysis of the interaction between von Willebrand factor A1 domain and glycoprotein Ibalpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

5 June 2018

Thrombin facilitates primary platelet adhesion onto vascular surfaces in the absence of plasma adhesive proteins: studies under flow conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

5 June 2018

Activation of factor VIII by thrombin increases its affinity for binding to synthetic phospholipid membranes and activated platelets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

5 June 2018

Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

5 June 2018

Oligonucleotide inhibitors of human thrombin that bind distinct epitopes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

5 June 2018

Structure and function of the glycoprotein Ib-IX-V complex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

5 June 2018

The linkage between binding of the C-terminal domain of hirudin and amidase activity in human alpha-thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

5 June 2018

Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

5 June 2018

Molecular mapping of the heparin-binding exosite of thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

5 June 2018

Identification of individual tyrosine sulfation sites within factor VIII required for optimal activity and efficient thrombin cleavage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

5 June 2018

Identification of three tyrosine residues of glycoprotein Ib alpha with distinct roles in von Willebrand factor and alpha-thrombin binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

5 June 2018

Thrombin proteolysis of purified factor viii procoagulant protein: correlation of activation with generation of a specific polypeptide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

5 June 2018

Mutations of factor VIII cleavage sites in hemophilia A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

5 June 2018

Differential proteolytic activation of factor VIII-von Willebrand factor complex by thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

5 June 2018

Direct characterization of factor VIII in plasma: detection of a mutation altering a thrombin cleavage site (arginine-372----histidine).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

5 June 2018

Hirudin, heparin, and placebo during deep arterial injury in the pig. The in vivo role of thrombin in platelet-mediated thrombosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

5 June 2018

The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

5 June 2018

Synthesis of tyrosin O-sulfate-containing peptides (author's transl)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

5 June 2018

Structural and functional mapping of the thrombin domain involved in the binding to the platelet glycoprotein Ib.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

18 August 2018

An extensive interaction interface between thrombin and factor V is required for factor V activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

18 August 2018

Unique pathway of thrombin-induced platelet aggregation mediated by glycoprotein Ib.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

18 August 2018

Isolation and characterization of thrombin-activated human factor VIII.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223494

18 August 2018

Flavone-8-acetic acid (Flavonoid) profoundly reduces platelet-dependent thrombosis and vasoconstriction after deep arterial injury In vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/12689334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of von willebrand factor-binding sites for platelet glycoprotein Ib and botrocetin by charged-to-alanine scanning mutagenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12689334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Platelet glycoprotein Ib alpha binds to thrombin anion-binding exosite II inducing allosteric changes in the activity of thrombin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12689334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of exosite ligands to human thrombin. Re-evaluation of allosteric linkage between thrombin exosites I and II

1 reference

https://pubmed.ncbi.nlm.nih.gov/12689334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BIOMEDICINE: Contact-How Platelets Touch von Willebrand Factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12689334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural requirements for the activation of human factor VIII by thrombin

1 reference

https://pubmed.ncbi.nlm.nih.gov/12689334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of the final deprotection system for the solid-phase synthesis of Tyr(SO3H)-containing peptides with 9-fluorenylmethyloxycarbonyl (Fmoc)-strategy and its application to the synthesis of cholecystokinin (CCK)-12

1 reference

https://pubmed.ncbi.nlm.nih.gov/12689334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of basic amino acid residues in thrombin essential for heparin-catalyzed inactivation by antithrombin III

1 reference

https://pubmed.ncbi.nlm.nih.gov/12689334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin plays a key role in late platelet thrombus growth and/or stability. Effect of a specific thrombin inhibitor on thrombogenesis induced by aortic subendothelium exposed to flowing rabbit blood

1 reference

https://pubmed.ncbi.nlm.nih.gov/12689334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abolition of cyclic flow variations in stenosed, endothelium-injured coronary arteries in nonhuman primates with a peptide fragment (VCL) derived from human plasma von Willebrand factor-glycoprotein Ib binding domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12689334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mocarhagin, a novel cobra venom metalloproteinase, cleaves the platelet von Willebrand factor receptor glycoprotein Ibalpha. Identification of the sulfated tyrosine/anionic sequence Tyr-276-Glu-282 of glycoprotein Ibalpha as a binding site for von W

1 reference

https://pubmed.ncbi.nlm.nih.gov/12689334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of thrombin anion-binding exosites 1 and 2 in the activation of factor V and factor VIII

1 reference

https://pubmed.ncbi.nlm.nih.gov/12689334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural and functional diversity in the leucine-rich repeat family of proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/12689334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for allosteric linkage between exosites 1 and 2 of thrombin

1 reference

https://pubmed.ncbi.nlm.nih.gov/12689334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-thrombotic effects of CX-397, a recombinant hirudin analog, in a canine model of coronary artery thrombosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12689334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular analyses of the platelet glycoprotein Ib-IX-V receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12689334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Asp(272)-Glu(282) region of platelet glycoprotein Ibalpha interacts with the heparin-binding site of alpha-thrombin and protects the enzyme from the heparin-catalyzed inhibition by antithrombin III

1 reference

https://pubmed.ncbi.nlm.nih.gov/12689334

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ20030167

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

ResearchGate publication ID

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