(Q77296407)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11724802%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

title

Binding of exosite ligands to human thrombin. Re-evaluation of allosteric linkage between thrombin exosites I and II (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11724802%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

4

Paul E Bock

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11724802%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

1

Ingrid M Verhamme

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11724802%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

author name string

Steven T Olson

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11724802%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

Douglas M Tollefsen

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11724802%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

language of work or name

English

0 references

publication date

27 November 2001

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11724802%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

4 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11724802%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

volume

277

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11724802%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11724802%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

page(s)

6788-6798

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11724802%20AND%20SRC:MED&resulttype=core&format=json

A player of many parts: the spotlight falls on thrombin's structure.

4 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Refined structure of the hirudin-thrombin complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Characterization of proexosite I on prothrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Substrate-assisted catalysis of the PAR1 thrombin receptor. Enhancement of macromolecular association and cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Molecular mapping of the heparin-binding exosite of thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Crystal structure of the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Allosteric effects of a monoclonal antibody against thrombin exosite II

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Involvement of thrombin anion-binding exosites 1 and 2 in the activation of factor V and factor VIII

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

An extensive interaction interface between thrombin and factor V is required for factor V activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Role of regulatory exosite I in binding of thrombin to human factor V, factor Va, factor Va subunits, and activation fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Demonstration of exosite I-dependent interactions of thrombin with human factor V and factor Va involving the factor Va heavy chain: analysis by affinity chromatography employing a novel method for active-site-selective immobilization of serine prot

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

The Asp(272)-Glu(282) region of platelet glycoprotein Ibalpha interacts with the heparin-binding site of alpha-thrombin and protects the enzyme from the heparin-catalyzed inhibition by antithrombin III

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Platelet glycoprotein Ib alpha binds to thrombin anion-binding exosite II inducing allosteric changes in the activity of thrombin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Bothrojaracin: a potent two-site-directed thrombin inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Effect of thrombomodulin on the kinetics of the interaction of thrombin with substrates and inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Localization of the thrombin-binding domain on prothrombin fragment 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Fibrin monomer protects thrombin from inactivation by heparin-antithrombin III: implications for heparin efficacy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Binding of fibrin monomer and heparin to thrombin in a ternary complex alters the environment of the thrombin catalytic site, reduces affinity for hirudin, and inhibits cleavage of fibrinogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Inactivation of thrombin by antithrombin is accompanied by inactivation of regulatory exosite I

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Molecular mechanisms of thrombin function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Evidence for allosteric linkage between exosites 1 and 2 of thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Characteristics of the association between prothrombin fragment 2 and alpha-thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Comparison of the esterase activities of trypsin, plasmin, and thrombin on guanidinobenzoate esters. Titration of the enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Kinetic characterization of heparin-catalyzed and uncatalyzed inhibition of blood coagulation proteinases by antithrombin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

The Size and Shape of Human and Bovine Antithrombin III

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Identification of a monoclonal thrombin inhibitor associated with multiple myeloma and a severe bleeding disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Thioester peptide chloromethyl ketones: reagents for active site-selective labeling of serine proteinases with spectroscopic probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Active site selective labeling of serine proteases with spectroscopic probes using thioester peptide chloromethyl ketones: demonstration of thrombin labeling using N alpha-[(acetylthio)acetyl]-D-Phe-Pro-Arg-CH2Cl

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Papain labelled with fluorescent thiol-specific reagents as a probe for characterization of interactions between cysteine proteinases and their protein inhibitors by competitive titrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Quantitative evaluation of solution equilibrium binding interactions by affinity partitioning: application to specific and nonspecific protein-heparin interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

New insights into the regulation of the blood clotting cascade derived from the X-ray crystal structure of bovine meizothrombin des F1 in complex with PPACK

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Exosites 1 and 2 are essential for protection of fibrin-bound thrombin from heparin-catalyzed inhibition by antithrombin and heparin cofactor II

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Molecular basis for the susceptibility of fibrin-bound thrombin to inactivation by heparin cofactor ii in the presence of dermatan sulfate but not heparin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

Structure of the non-covalent complex of prothrombin kringle 2 with PPACK-thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110257200

21 January 2018

Identifiers

DOI

10.1074/JBC.M110257200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11724802%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

1 reference