(Q41950879)

14 October 2017

Inhibition of beta2-microglobulin amyloid fibril formation by alpha2-macroglobulin (English)

1 reference

14 October 2017

Daisaku Ozawa

1

1 reference

14 October 2017

Kazuhiro Hasegawa

2

1 reference

14 October 2017

Young-Ho Lee

3

1 reference

14 October 2017

Kazumasa Sakurai

4

1 reference

14 October 2017

Kotaro Yanagi

5

1 reference

14 October 2017

Tadakazu Ookoshi

6

1 reference

14 October 2017

Yuji Goto

7

1 reference

14 October 2017

Hironobu Naiki

8

1 reference

14 October 2017

language of work or name

English

0 references

publication date

7 January 2011

1 reference

Journal of Biological Chemistry

14 October 2017

1 reference

14 October 2017

286

1 reference

14 October 2017

11

1 reference

14 October 2017

9668-9676

1 reference

Native-unlike long-lived intermediates along the folding pathway of the amyloidogenic protein beta2-microglobulin revealed by real-time two-dimensional NMR.

14 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

Identification of human plasma proteins as major clients for the extracellular chaperone clusterin

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

beta(2)-microglobulin: from physiology to amyloidosis

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

Molecular pathogenesis of protein misfolding diseases: pathological molecular environments versus quality control systems against misfolded proteins

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

Structural characterization of clusterin-chaperone client protein complexes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

Extracellular chaperones modulate the effects of Alzheimer's patient cerebrospinal fluid on Abeta(1-42) toxicity and uptake

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

Amyloid formation by globular proteins under native conditions

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

Potential roles of abundant extracellular chaperones in the control of amyloid formation and toxicity.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

Abeta-2M-amyloidosis and related bone diseases

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

The effects of extracellular pH on immune function

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

The alternative conformations of amyloidogenic proteins and their multi-step assembly pathways

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

Does an acidic pH explain why low density lipoprotein is oxidised in atherosclerotic lesions?

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

Alpha-macroglobulins: structure, shape, and mechanism of proteinase complex formation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

Model of alpha 2-macroglobulin structure and function

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

The H(+)-induced dissociation of human plasma alpha 2-macroglobulin. An investigation using small-angle neutron scattering and test of trypsin binding activity.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

Phosphorus nuclear magnetic resonance of perfused working rat hearts

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

Growth of beta(2)-microglobulin-related amyloid fibrils by non-esterified fatty acids at a neutral pH.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

Lysophospholipids induce the nucleation and extension of beta2-microglobulin-related amyloid fibrils at a neutral pH.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

Structural dynamics of archaeal small heat shock proteins

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

Fibril growth kinetics reveal a region of beta2-microglobulin important for nucleation and elongation of aggregation

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

Amyloid nucleation triggered by agitation of beta2-microglobulin under acidic and neutral pH conditions

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

Heparin strongly enhances the formation of beta2-microglobulin amyloid fibrils in the presence of type I collagen

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

Amyloid formation under physiological conditions proceeds via a native-like folding intermediate.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

A systematic study of the effect of physiological factors on beta2-microglobulin amyloid formation at neutral pH.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

A chemically modified preparation of alpha2-macroglobulin binds beta-amyloid peptide with increased affinity and inhibits Abeta cytotoxicity.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

Seeding-dependent maturation of beta2-microglobulin amyloid fibrils at neutral pH.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

Low concentrations of sodium dodecyl sulfate induce the extension of beta 2-microglobulin-related amyloid fibrils at a neutral pH.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

Amyloid fibril formation in the context of full-length protein: effects of proline mutations on the amyloid fibril formation of beta2-microglobulin

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

Concentration-dependent inhibitory effects of apolipoprotein E on Alzheimer's beta-amyloid fibril formation in vitro.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

Evaluation of pH changes in inflammation of the subcutaneous air pouch lining in the rat, induced by carrageenan, dextran and Staphylococcus aureus.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

Collagen plays an active role in the aggregation of beta2-microglobulin under physiopathological conditions of dialysis-related amyloidosis

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059021

alpha2-Macroglobulin and haptoglobin suppress amyloid formation by interacting with prefibrillar protein species

3 November 2018

1 reference

12 December 2020

alpha2-Macroglobulin, the main serum antiprotease, binds beta2-microglobulin, the light chain of the class I major histocompatibility complex, which is involved in human disease

1 reference

12 December 2020

The three-dimensional structure of the human alpha 2-macroglobulin dimer reveals its structural organization in the tetrameric native and chymotrypsin alpha 2-macroglobulin complexes

1 reference

12 December 2020

Mildly acidic pH activates the extracellular molecular chaperone clusterin

1 reference

12 December 2020

Circulating level of alpha2-macroglobulin-beta2-microglobulin complex in hemodialysis patients

1 reference

12 December 2020

Distribution of ?2-macroglobulin in normal, inflammatory, and tumor tissues in rats

1 reference

12 December 2020

A new form of amyloid protein associated with chronic hemodialysis was identified as beta 2-microglobulin

1 reference

12 December 2020

Dodecylsulfate-induced dissociation of human alpha 2-macroglobulin. An investigation using small-angle neutron scattering and the equilibrium dialysis technique

1 reference

12 December 2020

Evidence for active half-molecules of alpha 2-macroglobulin formed by dissociation in urea

1 reference

12 December 2020

High-molecular-mass proteins in haemodialysis-associated amyloidosis

1 reference

12 December 2020

Dissociation of alpha 2 M-macroglobulin into functional half-molecules by mild acid treatment

1 reference

12 December 2020

Comparison of conformational changes of pregnancy zone protein and human alpha 2-macroglobulin, a study using hydrophobic affinity partitioning

1 reference

12 December 2020

Oxidative dissociation of human alpha 2-macroglobulin tetramers into dysfunctional dimers

1 reference

12 December 2020

The contact zones in human alpha2-macroglobulin--functional domains important for the regulation of the trapping mechanism

1 reference

12 December 2020

Formation of a stable oligomer of beta-2 microglobulin requires only transient encounter with Cu(II)

1 reference

12 December 2020

The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species

1 reference

12 December 2020

Protease activation of alpha2-macroglobulin modulates a chaperone-like action with broad specificity

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.167965

1 reference

14 October 2017

1 reference

14 October 2017

1 reference