(Q45997809)

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A chemically modified preparation of alpha2-macroglobulin binds beta-amyloid peptide with increased affinity and inhibits Abeta cytotoxicity.

scientific article published in April 2005

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Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/15773905

A chemically modified preparation of alpha2-macroglobulin binds beta-amyloid peptide with increased affinity and inhibits Abeta cytotoxicity. (English)

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/15773905

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Sanja Arandjelovic

2

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Sanja Arandjelovic

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

author name string

Joseph M Mettenburg

1

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/15773905

Steven L Gonias

3

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Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/15773905

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publication date

1 April 2005

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Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/15773905

Journal of Neurochemistry

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Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/15773905

93

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Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/15773905

1

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/15773905

53-62

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/15773905

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02995.X

21 January 2018

The electrophoretically ‘slow’ and ‘fast’ forms of the α2-macroglobulin molecule

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02995.X

21 January 2018

Alpha-2 macroglobulin is genetically associated with Alzheimer disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02995.X

21 January 2018

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02995.X

21 January 2018

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02995.X

21 January 2018

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02995.X

21 January 2018

Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02995.X

21 January 2018

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02995.X

21 January 2018

LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02995.X

21 January 2018

Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02995.X

21 January 2018

Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02995.X

21 January 2018

Alpha2-macroglobulin associates with beta-amyloid peptide and prevents fibril formation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02995.X

21 January 2018

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02995.X

21 January 2018

Crystal structure of the receptor-binding domain of alpha 2-macroglobulin

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02995.X

21 January 2018

Increased beta-amyloid release and levels of amyloid precursor protein (APP) in fibroblast cell lines from family members with the Swedish Alzheimer's disease APP670/671 mutation.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02995.X

21 January 2018

Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02995.X

21 January 2018

Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02995.X

21 January 2018

Distinct binding sites in the structure of alpha 2-macroglobulin mediate the interaction with beta-amyloid peptide and growth factors

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02995.X

21 January 2018

Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02995.X

21 January 2018

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02995.X

21 January 2018

The gene defects responsible for familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02995.X

21 January 2018

A protective role of the low density lipoprotein receptor-related protein against amyloid beta-protein toxicity

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02995.X

21 January 2018

Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02995.X

21 January 2018

Chemical modification of alpha2-macroglobulin to generate derivatives that bind transforming growth factor-beta with increased affinity

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02995.X

21 January 2018

Localization of the binding site for transforming growth factor-beta in human alpha2-macroglobulin to a 20-kDa peptide that also contains the bait region

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02995.X

21 January 2018

Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02995.X

21 January 2018

Identifiers

10.1111/J.1471-4159.2004.02995.X

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/15773905

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/15773905

ResearchGate publication ID

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