(Q30308620)

16 June 2017

Distinct binding sites in the structure of alpha 2-macroglobulin mediate the interaction with beta-amyloid peptide and growth factors (English)

1 reference

16 June 2017

Joseph M Mettenburg

1

1 reference

16 June 2017

Donna J Webb

series ordinal

2

1 reference

16 June 2017

Steven L Gonias

series ordinal

3

1 reference

16 June 2017

language of work or name

English

0 references

publication date

31 January 2002

1 reference

Journal of Biological Chemistry

16 June 2017

8

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

16 June 2017

277

1 reference

16 June 2017

13338-13345

1 reference

16 June 2017

15

1 reference

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

16 June 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Amyloid, the presenilins and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Apolipoprotein E deposition and astrogliosis are associated with maturation of beta-amyloid plaques in betaAPPswe transgenic mouse: Implications for the pathogenesis of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Alpha 2-macroglobulin and the alpha 2-macroglobulin receptor/LRP. A growth regulatory axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Alpha-2 macroglobulin is genetically associated with Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

The electrophoretically ‘slow’ and ‘fast’ forms of the α2-macroglobulin molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Localization of the binding site for transforming growth factor-beta in human alpha2-macroglobulin to a 20-kDa peptide that also contains the bait region

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Identical or overlapping sequences in the primary structure of human alpha(2)-macroglobulin are responsible for the binding of nerve growth factor-beta, platelet-derived growth factor-BB, and transforming growth factor-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

A 16-amino acid peptide from human alpha2-macroglobulin binds transforming growth factor-beta and platelet-derived growth factor-BB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Alpha2 macroglobulin and the risk of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Association of alpha-2-macroglobulin deletion polymorphism with sporadic Alzheimer's disease in Koreans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Lack of association of the alpha2-macroglobulin locus on chromosome 12 in AD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

alpha 2-Macroglobulin expression in neuritic-type plaques in patients with Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Alpha 2-macroglobulin functions as a cytokine carrier to induce nitric oxide synthesis and cause nitric oxide-dependent cytotoxicity in the RAW 264.7 macrophage cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Native and activated forms of alpha 2-macroglobulin increase expression of platelet-derived growth factor alpha-receptor in vascular smooth muscle cells. Evidence for autocrine transforming growth factor-beta activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Activated alpha2macroglobulin increases beta-amyloid (25-35)-induced toxicity in LAN5 human neuroblastoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Transforming growth factor-beta inhibits apoptosis induced by beta-amyloid peptide fragment 25-35 in cultured neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Transforming growth factor-betas in neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Role of the low-density lipoprotein receptor-related protein in beta-amyloid metabolism and Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Alpha2-macroglobulin associates with beta-amyloid peptide and prevents fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Selective mutations in cloned and expressed alpha-macroglobulin receptor binding fragment alter binding to either the alpha2-macroglobulin signaling receptor or the low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Crystal structure of the receptor-binding domain of alpha 2-macroglobulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Physical properties of human alpha 2-macroglobulin following reaction with methylamine and trypsin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

The structure of α2-macroglobulin-methylamine after papain digestion as determined by electron microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Neurotrophin binding to human alpha 2-macroglobulin under apparent equilibrium conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

LRP in Alzheimer's disease: friend or foe?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

The interaction of alpha 2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Metabolic regulation of brain Abeta by neprilysin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Alpha 2-macroglobulin and other proteinase inhibitors do not interfere with the secretion of amyloid precursor protein in mouse neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

An alpha 2-macroglobulin receptor-dependent mechanism for the plasma clearance of transforming growth factor-beta 1 in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Binding of platelet-derived growth factor-BB and transforming growth factor-beta 1 to alpha 2-macroglobulin in vitro and in vivo: comparison of receptor-recognized and non-recognized alpha 2-macroglobulin conformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Genetic association of alpha2-macroglobulin with Alzheimer's disease in a Finnish elderly population

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

The alpha2-macroglobulin gene in AD: a population-based study and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

Identification of residues in alpha-macroglobulins important for binding to the alpha2-macroglobulin receptor/Low density lipoprotein receptor-related protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

NMR solution structure of the receptor binding domain of human alpha(2)-macroglobulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

A thiol-ester in α2-macroglobulin cleaved during proteinase complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106792200

21 January 2018

Identifiers

DOI

10.1074/JBC.M106792200

1 reference

16 June 2017

1 reference