(Q41966212)

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Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasia.

scientific article published on 4 February 2013

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23 February 2020

Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasia (English)

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23 February 2020

M Elizabeth Moss

2

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23 February 2020

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K C Ray

1

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23 February 2020

J L Franklin

3

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23 February 2020

C J Weaver

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23 February 2020

J Higginbotham

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23 February 2020

Y Song

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23 February 2020

F L Revetta

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23 February 2020

S A Blaine

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23 February 2020

L R Bridges

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23 February 2020

K E Guess

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23 February 2020

R J Coffey

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23 February 2020

H C Crawford

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23 February 2020

M K Washington

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23 February 2020

A L Means

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23 February 2020

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4 February 2013

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23 February 2020

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23 February 2020

33

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23 February 2020

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23 February 2020

823-831

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23 February 2020

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11 June 2022

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based on heuristic

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https://scigraph.springernature.com/pub.10.1038/onc.2013.3

0 references

EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma

1 reference

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5 June 2018

EGF receptor is required for KRAS-induced pancreatic tumorigenesis

1 reference

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5 June 2018

CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans

1 reference

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5 June 2018

mTORC1 signaling: what we still don't know

1 reference

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5 June 2018

The epidermal growth factor receptor inhibitor gefitinib prevents the progression of pancreatic lesions to carcinoma in a conditional LSL-KrasG12D/+ transgenic mouse model.

1 reference

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5 June 2018

Alternative macrophage activation and metabolism

1 reference

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5 June 2018

Adult pancreatic acinar cells give rise to ducts but not endocrine cells in response to growth factor signaling

1 reference

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5 June 2018

Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma

1 reference

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5 June 2018

Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice

1 reference

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5 June 2018

Transmembrane and soluble isoforms of heparin-binding epidermal growth factor-like growth factor regulate distinct processes in the pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929321

5 June 2018

Epidermal growth factor receptor regulates pancreatic fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929321

5 June 2018

Ras activity levels control the development of pancreatic diseases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929321

5 June 2018

Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929321

5 June 2018

Advances in counselling and surveillance of patients at risk for pancreatic cancer

1 reference

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5 June 2018

Inactivation of Smad4 accelerates Kras(G12D)-mediated pancreatic neoplasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929321

5 June 2018

Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929321

5 June 2018

Biochemical and functional characterization of three activated macrophage populations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929321

5 June 2018

Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop

1 reference

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5 June 2018

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929321

5 June 2018

Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929321

5 June 2018

ErbB receptors: directing key signaling networks throughout life

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929321

5 June 2018

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929321

5 June 2018

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929321

5 June 2018

Expression of Heparin-Binding Epidermal Growth Factor-like Growth Factor in Pancreatic Adenocarcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929321

5 June 2018

The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929321

5 June 2018

Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929321

5 June 2018

A raf-independent epidermal growth factor receptor autocrine loop is necessary for Ras transformation of rat intestinal epithelial cells

1 reference

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5 June 2018

Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation

1 reference

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5 June 2018

Lessons from hereditary colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929321

5 June 2018

Induction and expression of heparin-binding EGF-like growth factor in human pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3929321

5 June 2018

KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas

1 reference

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Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo

1 reference

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Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ.

1 reference

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Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1 reference

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A Heparin-Binding Growth Factor Secreted by Macrophage-Like Cells That Is Related to EGF

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Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha

1 reference

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1 reference

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1 reference

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Epiregulin Is Up-Regulated in Pancreatic Cancer and Stimulates Pancreatic Cancer Cell Growth

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.3

21 January 2018

Pancreatic carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.3

31 March 2020

Duct changes and K-ras mutations in the disease-free pancreas: analysis of type, age relation and spatial distribution

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.3

31 March 2020

Molecular pathogenesis of pancreatic cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.3

31 March 2020

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1 reference

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Development of secretagogue response in rat pancreatic acinar cells

1 reference

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Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.3

31 March 2020

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10.1038/ONC.2013.3

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23 February 2020

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23 February 2020

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23 February 2020

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