(Q37817590)

23 August 2017

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title

mTORC1 signaling: what we still don't know (English)

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23 August 2017

2

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23 August 2017

Xuemin Wang

1

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23 August 2017

publication date

7 December 2010

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Journal of Molecular Cell Biology

23 August 2017

published in

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23 August 2017

volume

3

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23 August 2017

issue

4

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23 August 2017

page(s)

206-220

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Regulation of cyclin D1 expression by mTORC1 signaling requires eukaryotic initiation factor 4E-binding protein 1.

23 August 2017

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A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1.

21 January 2018

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Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.

21 January 2018

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Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors.

21 January 2018

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PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR

21 January 2018

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Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability

21 January 2018

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Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1

21 January 2018

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The Vam6 GEF controls TORC1 by activating the EGO complex

21 January 2018

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Disruption of the gene encoding the mitogen-regulated translational modulator PHAS-I in mice.

21 January 2018

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Calorie restriction: decelerating mTOR-driven aging from cells to organisms (including humans).

21 January 2018

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Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

21 January 2018

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MAP4K3 regulates body size and metabolism in Drosophila

21 January 2018

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p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

21 January 2018

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Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

21 January 2018

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Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation

21 January 2018

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Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage

21 January 2018

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Cytoprotective effect of the elongation factor-2 kinase-mediated autophagy in breast cancer cells subjected to growth factor inhibition

21 January 2018

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Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

21 January 2018

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Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

21 January 2018

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Translational control of the innate immune response through IRF-7

21 January 2018

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mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex

21 January 2018

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Paradoxical suppression of cellular senescence by p53

21 January 2018

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Mammalian TOR: a homeostatic ATP sensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Tsc2 is not a critical target of Akt during normal Drosophila development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Molecular Basis of the Acceleration of the GDP-GTP Exchange of Human Ras Homolog Enriched in Brain by Human Translationally Controlled Tumor Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

FKBP12-Rapamycin-associated Protein or Mammalian Target of Rapamycin (FRAP/mTOR) Localization in the Endoplasmic Reticulum and the Golgi Apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

The TOR and EGO protein complexes orchestrate microautophagy in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Phosphatidic acid-mediated mitogenic activation of mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Cap in hand: targeting eIF4E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

The late endosome is essential for mTORC1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Extending healthy life span--from yeast to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

AMPK phosphorylation of raptor mediates a metabolic checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Regulation of the 14-3-3-binding protein p39 by growth factors and nutrients in rat PC12 pheochromocytoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

p53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

The TSC1-TSC2 complex: a molecular switchboard controlling cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Blocking eukaryotic initiation factor 4F complex formation does not inhibit the mTORC1-dependent activation of protein synthesis in cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

TSC2 mediates cellular energy response to control cell growth and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

mTOR regulation of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Dietary restriction and aging, 2009.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Regulation of TORC1 by Rag GTPases in nutrient response

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Identification of a proline-rich Akt substrate as a 14-3-3 binding partner

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

A role for Phospholipase D in Drosophila embryonic cellularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Analysis of the regulatory motifs in eukaryotic initiation factor 4E-binding protein 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Induction of p21 and p27 expression by amino acid deprivation of HepG2 human hepatoma cells involves mRNA stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Rheb binds and regulates the mTOR kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

PRAS40 deregulates apoptosis in malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Ribosome biogenesis and cell growth: mTOR coordinates transcription by all three classes of nuclear RNA polymerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Autophagy: regulation and role in disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

mTORC1 directly phosphorylates and regulates human MAF1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Drosophila S6 kinase: a regulator of cell size

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

In rat hepatocytes glucagon increases mammalian target of rapamycin phosphorylation on serine 2448 but antagonizes the phosphorylation of its downstream targets induced by insulin and amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Regulation of protein phosphatase 2A catalytic activity by alpha4 protein and its yeast homolog Tap42

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

PRAS40: target or modulator of mTORC1 signalling and insulin action?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Signalling to translation: how signal transduction pathways control the protein synthetic machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Dynamic balancing: DEPTOR tips the scales

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

A critical role of eEF-2K in mediating autophagy in response to multiple cellular stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Biochemical characterisation of TCTP questions its function as a guanine nucleotide exchange factor for Rheb

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Exercise- and nutrient-controlled mechanisms involved in maintenance of the musculoskeletal mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

SKAR is a specific target of S6 kinase 1 in cell growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Regulation of the small GTPase Rheb by amino acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Mice deficient in ribosomal protein S6 phosphorylation suffer from muscle weakness that reflects a growth defect and energy deficit

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Role of 3'UTRs in the translation of mRNAs regulated by oncogenic eIF4E--a computational inference

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Rheb promotes cell growth as a component of the insulin/TOR signalling network

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Identification of a conserved motif required for mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Lobe and Serrate are required for cell survival during early eye development in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Phospholipase D1 is an effector of Rheb in the mTOR pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Chromatin-mediated regulation of nucleolar structure and RNA Pol I localization by TOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

mTOR binds to the promoters of RNA polymerase I- and III-transcribed genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Protein synthesis upon acute nutrient restriction relies on proteasome function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Reduction of Lobe leads to TORC1 hypoactivation that induces ectopic Jak/STAT signaling to impair Drosophila eye development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Nutrient control of TORC1, a cell-cycle regulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

How common are extraribosomal functions of ribosomal proteins?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

TORC1 association with rDNA chromatin as a mechanism to co-regulate Pol I and Pol III.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Dissecting eIF4E action in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Integration of nutritional and stress signaling pathways by Maf1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Elongation factor-2 kinase regulates autophagy in human glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Silencing of elongation factor-2 kinase potentiates the effect of 2-deoxy-D-glucose against human glioma cells through blunting of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Structure of the human mTOR complex I and its implications for rapamycin inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

Predominant nuclear localization of mammalian target of rapamycin in normal and malignant cells in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJQ038

21 January 2018

Identifiers

DOI

10.1093/JMCB/MJQ038

1 reference

23 August 2017

1 reference