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English
Regulation of the small GTPase Rheb by amino acids.
scientific article published on February 2006
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
16170341
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16170341%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
title
Regulation of the small GTPase Rheb by amino acids
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
16170341
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16170341%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
author
Marta Roccio
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
16170341
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16170341%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
author name string
Bos JL
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
16170341
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16170341%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
Zwartkruis FJ
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed ID
16170341
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16170341%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
language of work or name
English
0 references
publication date
1 February 2006
1 reference
stated in
Europe PubMed Central
PubMed ID
16170341
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16170341%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
published in
Oncogene
1 reference
stated in
Europe PubMed Central
PubMed ID
16170341
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16170341%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
volume
25
1 reference
stated in
Europe PubMed Central
PubMed ID
16170341
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16170341%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
page(s)
657-664
1 reference
stated in
Europe PubMed Central
PubMed ID
16170341
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16170341%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
issue
5
1 reference
stated in
Europe PubMed Central
PubMed ID
16170341
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16170341%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
exact match
https://scigraph.springernature.com/pub.10.1038/sj.onc.1209106
0 references
cites work
Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mammalian TOR: a homeostatic ATP sensor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TSC2 mediates cellular energy response to control cell growth and survival
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of TSC2 by 14-3-3 binding
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tuberous sclerosis complex: from Drosophila to human disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Akt regulates growth by directly phosphorylating Tsc2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SKAR is a specific target of S6 kinase 1 in cell growth control
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rheb promotes cell growth as a component of the insulin/TOR signalling network
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Integration of growth factor and nutrient signaling: implications for cancer biology
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TOR signalling and control of cell growth
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stimulation of gene induction and cell growth by the Ras effector Rlf
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/SJ.ONC.1209106
1 reference
stated in
Europe PubMed Central
PubMed ID
16170341
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16170341%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
Dimensions Publication ID
1034184478
0 references
PubMed ID
16170341
1 reference
stated in
Europe PubMed Central
PubMed ID
16170341
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16170341%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
ResearchGate publication ID
7594105
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