(Q40054340)

16 September 2017

title

Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38. (English)

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16 September 2017

Xiaochun Bai

1

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16 September 2017

Dongzhu Ma

2

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16 September 2017

Anling Liu

3

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16 September 2017

Xiaoyun Shen

4

1 reference

16 September 2017

Qiming J Wang

5

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16 September 2017

Yongjian Liu

6

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16 September 2017

Yu Jiang

7

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16 September 2017

language of work or name

English

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publication date

1 November 2007

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16 September 2017

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16 September 2017

volume

318

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16 September 2017

issue

5852

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16 September 2017

page(s)

977-980

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The expanding TOR signaling network

16 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1147379

TOR signaling in growth and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1147379

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1147379

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1147379

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1147379

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1147379

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1147379

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1147379

The Rheb family of GTP-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1147379

Rheb fills a GAP between TSC and TOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1147379

TSC2: filling the GAP in the mTOR signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1147379

Bcl-2 regulator FKBP38 is activated by Ca2+/calmodulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1147379

Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1147379

Rheb binds and regulates the mTOR kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1147379

Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1147379

Regulation of the small GTPase Rheb by amino acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1147379

Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1147379

Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1147379

The specific FKBP38 inhibitor N-(N',N'-dimethylcarboxamidomethyl)cycloheximide has potent neuroprotective and neurotrophic properties in brain ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1147379

21 January 2018

Identifiers

DOI

10.1126/SCIENCE.1147379

1 reference

16 September 2017

1 reference