(Q37500523)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19480563%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

review article

1 reference

title

PRAS40: target or modulator of mTORC1 signalling and insulin action? (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19480563%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19480563%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Margriet Ouwens

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19480563%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

author name string

Emmani B M Nascimento

series ordinal

1

1 reference

20 August 2017

D Margriet Ouwens

series ordinal

2

1 reference

20 August 2017

1 October 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19480563%20AND%20SRC:MED&resulttype=core&format=json

Archives of Physiology and Biochemistry

29 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19480563%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

volume

115

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19480563%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19480563%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

page(s)

163-175

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19480563%20AND%20SRC:MED&resulttype=core&format=json

Two phases of palmitate-induced insulin resistance in skeletal muscle: impaired GLUT4 translocation is followed by a reduced GLUT4 intrinsic activity.

29 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Large-scale characterization of HeLa cell nuclear phosphoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Control of p70 s6 kinase by kinase activity of FRAP in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Mammalian target of rapamycin complex 1: signalling inputs, substrates and feedback mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Identification and characterization of the tuberous sclerosis gene on chromosome 16

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Activation of phosphatidylinositol 3-kinase signaling by a mutant thyroid hormone beta receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

A chronic increase in physical activity inhibits fed-state mTOR/S6K1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Defining the role of mTOR in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Regulation of eIF-4E BP1 phosphorylation by mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Regulation of the 14-3-3-binding protein p39 by growth factors and nutrients in rat PC12 pheochromocytoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Exploiting the PI3K/AKT pathway for cancer drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Nutrient sensing and inflammation in metabolic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

The TSC1-TSC2 complex: a molecular switchboard controlling cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

TSC2 mediates cellular energy response to control cell growth and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Loss of 50% of excess weight using a very low energy diet improves insulin-stimulated glucose disposal and skeletal muscle insulin signalling in obese insulin-treated type 2 diabetic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Increased STAT-3 and synchronous activation of Raf-1-MEK-1-MAPK, and phosphatidylinositol 3-Kinase-Akt-mTOR pathways in atypical and anaplastic meningiomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Regulation of TORC1 by Rag GTPases in nutrient response

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Identification of a proline-rich Akt substrate as a 14-3-3 binding partner

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

NESbase version 1.0: a database of nuclear export signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Recent developments in neurofibromatosis type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Insulin signaling in the pancreatic beta-cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

WW and SH3 domains, two different scaffolds to recognize proline-rich ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

PRAS40 deregulates apoptosis in malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Akt-dependent and -independent mechanisms of mTOR regulation in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Rapamycin does not improve insulin sensitivity despite elevated mammalian target of rapamycin complex 1 activity in muscles of ob/ob mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Cardiac contractile dysfunction in insulin-resistant rats fed a high-fat diet is associated with elevated CD36-mediated fatty acid uptake and esterification

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Nuclear export of S6K1 II is regulated by protein kinase CK2 phosphorylation at Ser-17

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

mTOR and the control of whole body metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

The mTOR pathway and its role in human genetic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Cytoplasmic/nuclear localization of tuberin in different cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Modulation of proline-rich akt substrate survival signaling pathways by oxidative stress in mouse brains after transient focal cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Akt1 contains a functional leucine-rich nuclear export sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Insulin signalling and the regulation of glucose and lipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Identification of a conserved motif required for mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

mTOR signaling: RAG GTPases transmit the amino acid signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Ras, PI(3)K and mTOR signalling controls tumour cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Lobe and Serrate are required for cell survival during early eye development in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Critical nodes in signalling pathways: insights into insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

TOR signaling in growth and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Increased expression of a proline-rich Akt substrate (PRAS40) in human copper/zinc-superoxide dismutase transgenic rats protects motor neurons from death after spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580

Hydrogen peroxide impairs insulin-stimulated assembly of mTORC1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450902988580