(Q42810841)

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Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1.

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scholarly article

1 reference

Europe PubMed Central

7 November 2017

Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1. (English)

1 reference

Europe PubMed Central

7 November 2017

1 reference

based on heuristic

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author name string

Margit Rosner

1

1 reference

Europe PubMed Central

7 November 2017

Markus Hengstschläger

2

1 reference

Europe PubMed Central

7 November 2017

publication date

8 July 2008

1 reference

Europe PubMed Central

7 November 2017

Human Molecular Genetics

1 reference

Europe PubMed Central

7 November 2017

17

1 reference

Europe PubMed Central

7 November 2017

2934-2948

1 reference

Europe PubMed Central

7 November 2017

19

1 reference

Europe PubMed Central

7 November 2017

Defining the role of mTOR in cancer

1 reference

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21 January 2018

Targeting the mTOR signaling network in cancer.

1 reference

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21 January 2018

mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

The two TORCs and Akt.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

The tuberous sclerosis complex

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity

1 reference

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21 January 2018

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

1 reference

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21 January 2018

The LKB1 tumor suppressor negatively regulates mTOR signaling

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Dysregulation of the TSC-mTOR pathway in human disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

The NF1 tumor suppressor critically regulates TSC2 and mTOR.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

TORC1 is essential for NF1-associated malignancies

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease

1 reference

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21 January 2018

Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Tuberin--a new molecular target in Alzheimer's disease?

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

RB1CC1 insufficiency causes neuronal atrophy through mTOR signaling alteration and involved in the pathology of Alzheimer's diseases

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Dissociation of Akt/PKB and ribosomal S6 kinase signaling markers in a transgenic mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Tuberous sclerosis complex (TSC) gene involvement in sporadic tumours

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Expression and prognostic value of tuberous sclerosis complex 2 gene product tuberin in human pancreatic cancer.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

The TSC1 gene product, hamartin, negatively regulates cell proliferation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

p27Kip1 localization depends on the tumor suppressor protein tuberin

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Renal-cell carcinoma--molecular pathways and therapies.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

"New"-clear functions of PDK1: beyond a master kinase in the cytosol?

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Translocation of Akt/PKB to the nucleus of osteoblast-like MC3T3-E1 cells exposed to proliferative growth factors

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Nuclear targeting of Akt antagonizes aspects of cardiomyocyte hypertrophy

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Nuclear Akt associates with PKC-phosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase-activated DNase

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

AKT can be activated in the nucleus.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Class reunion: PTEN joins the nuclear crew.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

The tuberous sclerosis 2 gene product can localize to nuclei in a phosphorylation-dependent manner

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Akt regulates nuclear/cytoplasmic localization of tuberin

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Ribosomal protein S6 phosphorylation: from protein synthesis to cell size.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Intranucleolar sites of ribosome biogenesis defined by the localization of early binding ribosomal proteins

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Predominant nuclear localization of mammalian target of rapamycin in normal and malignant cells in culture

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Activation of phosphatidylinositol 3-kinase signaling by a mutant thyroid hormone beta receptor

1 reference

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21 January 2018

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Rapamycin regulates the phosphorylation of rictor

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis

1 reference

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21 January 2018

Sirolimus therapy in tuberous sclerosis or sporadic lymphangioleiomyomatosis

1 reference

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21 January 2018

Efficacy of sirolimus in treating tuberous sclerosis and lymphangioleiomyomatosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN192

21 January 2018

Identifiers

10.1093/HMG/DDN192

1 reference

Europe PubMed Central

7 November 2017

1 reference

Europe PubMed Central

7 November 2017

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